Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver (original) (raw)
Cline, G. W. et al. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N. Engl. J. Med.341, 240–246 (1999). ArticleCAS Google Scholar
Roden, M. & Shulman, G. I. Applications of NMR spectroscopy to study muscle glycogen metabolism in man. Annu. Rev. Med.50, 277–290 (1999). ArticleCAS Google Scholar
Defronzo, R. A. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev.5, 177–269 (1997). Google Scholar
Shepherd, P. R. & Kahn, B. B. Glucose transporters and insulin action–implications for insulin resistance and diabetes mellitus. N. Engl. J. Med.341, 248–257 (1999). ArticleCAS Google Scholar
Abel, E. D. et al. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J. Clin. Invest.104, 1703–1714 (1999). ArticleCAS Google Scholar
Zisman, A. et al. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nature Med.6, 924–928 (2000). ArticleCAS Google Scholar
Ross, S. R. et al. A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. Proc. Natl Acad. Sci. USA87, 9590–9504 (1990). ArticleADSCAS Google Scholar
Zambrowicz, B. P. et al. Disruption of overlapping transcripts in the ROSA β geo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells. Proc. Natl Acad. Sci. USA94, 3789–3794 (1997). ArticleADSCAS Google Scholar
Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet.21, 70–71 (1999). ArticleCAS Google Scholar
Katz, E. B., Stenbit, A. E., Hatton, K., Depinho, R. & Charron, M. J. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature377, 151–155 (1995). ArticleADSCAS Google Scholar
Donoghue, M. J., Alvarez, J. D., Merlie, J. P. & Sanes, J. R. Fiber type- and position-dependent expression of a myosin light chain- CAT transgene detected with a novel histochemical stain for CAT. J. Cell Biol.115, 423–434 (1991). ArticleCAS Google Scholar
West, D. B., Boozer, C. N., Moody, D. L. & Atkinson, R. L. Dietary obesity in nine inbred mouse strains. Am. J. Physiol.262, R1025–R1032 (1992). CASPubMed Google Scholar
Boden, G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes46, 3–10 (1997). ArticleCAS Google Scholar
Muoio, D. M. et al. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes46, 1360–1363 (1997). ArticleCAS Google Scholar
Burcelin, R. et al. Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice. Diabetes48, 1264–1269 (1999). ArticleCAS Google Scholar
Hotamisligil, G. S. & Spiegelman, B. M. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes43, 1271–1278 (1994). ArticleCAS Google Scholar
Griffin, M. E. et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes48, 1270–1274 (1999). ArticleCAS Google Scholar
Dresner, A. et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest.103, 253–9 (1999). ArticleCAS Google Scholar
Mueller, W. M. et al. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology139, 551–558 (1998). ArticleCAS Google Scholar
Sivitz, W. I., Walsh, S. A., Morgan, D. A., Thomas, M. J. & Haynes, W. G. Effects of leptin on insulin sensitivity in normal rats. Endocrinology138, 3395–3401 (1997). ArticleCAS Google Scholar
Tozzo, E., Gnudi, L. & Kahn, B. B. Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter. Endocrinology138, 1604–1611 (1997). ArticleCAS Google Scholar
Cushman, S. W. & Salans, L. B. Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells. J. Lipid Res.19, 269–273 (1978). CASPubMed Google Scholar
Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L. & Shulman, G. I. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J. Biol. Chem.275, 8456–8460 (2000). ArticleCAS Google Scholar
Kim, Y. B. et al. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Diabetes48, 310–320 (1999). ArticleCAS Google Scholar
Storlien, L. H. et al. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes40, 280–289 (1991). ArticleCAS Google Scholar