Interventional strategies against prion diseases (original) (raw)
Aguzzi, A., Montrasio, F. & Kaeser, P. S. Prions: health scare and biological challenge. Nature Rev. Mol. Cell Biol.2, 118–126 (2001). ArticleCAS Google Scholar
Weissmann, C. & Aguzzi, A. Bovine spongiform encephalopathy and early onset variant Creutzfeldt–Jakob disease. Curr. Opin. Neurobiol.7, 695–700 (1997). ArticleCASPubMed Google Scholar
Yamamoto, A., Lucas, J. J. & Hen, R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell101, 57–66 (2000). ArticleCASPubMed Google Scholar
Tremblay, P. et al. Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc. Natl Acad. Sci. USA95, 12580–12585 (1998). ArticleCASPubMedPubMed Central Google Scholar
Bruce, M. E. et al. Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature389, 498–501 (1997). ArticleCASPubMed Google Scholar
Brandner, S. et al. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature379, 339–343 (1996). ArticleCASPubMed Google Scholar
Korth, C., May, B. C., Cohen, F. E. & Prusiner, S. B. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc. Natl Acad. Sci. USA98, 9836–9841 (2001). ArticleCASPubMedPubMed Central Google Scholar
Roikhel, V. M., Fokina, G. I. & Pogodina, V. V. Influence of aminasine on experimental scrapie in mice. Acta Virol.28, 321–324 (1984). CASPubMed Google Scholar
Doh-Ura, K., Iwaki, T. & Caughey, B. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J. Virol.74, 4894–4897 (2000). ArticleCASPubMedPubMed Central Google Scholar
Aguzzi, A. & Weissmann, C. Sleepless in Bologna: transmission of fatal familial insomnia. Trends Microbiol.4, 129–131 (1996). ArticleCASPubMed Google Scholar
Caughey, B. & Race, R. E. Potent inhibition of scrapie-associated PrP accumulation by Congo red. J. Neurochem.59, 768–771 (1992). ArticleCASPubMed Google Scholar
Pocchiari, M., Schmittinger, S. & Masullo, C. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. J. Gen. Virol.68, 219–223 (1987). ArticleCASPubMed Google Scholar
Tagliavini, F. et al. Effectiveness of anthracycline against experimental prion disease in Syrian hamsters. Science276, 1119–1122 (1997). ArticleCASPubMed Google Scholar
Caughey, B. & Raymond, G. J. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. J. Virol.67, 643–650 (1993). CASPubMedPubMed Central Google Scholar
Farquhar, C., Dickinson, A. & Bruce, M. Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies. Lancet353, 117 (1999). ArticleCASPubMed Google Scholar
Montrasio, F. et al. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science288, 1257–1259 (2000). ArticleCASPubMed Google Scholar
Priola, S. A., Raines, A. & Caughey, W. S. Porphyrin and phthalocyanine antiscrapie compounds. Science287, 1503–1506 (2000). ArticleCASPubMed Google Scholar
Soto, C. et al. Reversion of prion protein conformational changes by synthetic β-sheet breaker peptides. Lancet355, 192–197 (2000). ArticleCASPubMed Google Scholar
Aguzzi, A. Neuro-immune connection in spread of prions in the body? Lancet349, 742–743 (1997). ArticleCASPubMed Google Scholar
Heppner, F. L. et al. Transepithelial prion transport by M cells. Nature Med.7, 976–977 (2001). ArticleCASPubMed Google Scholar
Mackay, F. & Browning, J. L. Turning off follicular dendritic cells. Nature395, 26–27 (1998). ArticleCASPubMed Google Scholar
Mabbott, N. A., Mackay, F., Minns, F. & Bruce, M. E. Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nature Med.6, 719–720 (2000). ArticleCASPubMed Google Scholar
Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature350, 423–426 (1991). ArticleCASPubMed Google Scholar
Klein, M. A. et al. A crucial role for B cells in neuroinvasive scrapie. Nature390, 687–690 (1997). ArticleCASPubMed Google Scholar
Klein, M. A. et al. PrP expression in B lymphocytes is not required for prion neuroinvasion. Nature Med.4, 1429–1433 (1998). ArticleCASPubMed Google Scholar
Shlomchik, M. J., Radebold, K., Duclos, N. & Manuelidis, L. Neuroinvasion by a Creutzfeldt–Jakob disease agent in the absence of B cells and follicular dendritic cells. Proc. Natl Acad. Sci. USA98, 9289–9294 (2001). ArticleCASPubMedPubMed Central Google Scholar
Ware, C. F., VanArsdale, T. L., Crowe, P. D. & Browning, J. L. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol.198, 175–218 (1995). CASPubMed Google Scholar
Futterer, A., Mink, K., Luz, A., Kosco-Vilbois, M. H. & Pfeffer, K. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity9, 59–70 (1998). ArticleCASPubMed Google Scholar
Rennert, P. D., Browning, J. L., Mebius, R., Mackay, F. & Hochman, P. S. Surface lymphotoxin α/β complex is required for the development of peripheral lymphoid organs. J. Exp. Med.184, 1999–2006 (1996). ArticleCASPubMed Google Scholar
Koni, P. A. et al. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity6, 491–500 (1997). ArticleCASPubMed Google Scholar
De Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science264, 703–707 (1994). ArticleCASPubMed Google Scholar
Korner, H. et al. Distinct roles for lymphotoxin-α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur. J. Immunol.27, 2600–2609 (1997). ArticleCASPubMed Google Scholar
Klein, M. A. et al. Complement facilitates early prion pathogenesis. Nature Med.7, 488–492 (2001). ArticleCASPubMed Google Scholar
Mabbott, N. A., Bruce, M. E., Botto, M., Walport, M. J. & Pepys, M. B. Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie. Nature Med.7, 485–487 (2001). ArticleCASPubMed Google Scholar
Picklo, M. J. Methods of sympathetic degeneration and alteration. J. Auton. Nerv. Syst.62, 111–125 (1997). ArticleCASPubMed Google Scholar
Glatzel, M., Heppner, F. L., Albers, K. M. & Aguzzi, A. Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion. Neuron31, 25–34 (2001). ArticleCASPubMed Google Scholar
Gabizon, R., McKinley, M. P., Groth, D. & Prusiner, S. B. Immunoaffinity purification and neutralization of scrapie prion infectivity. Proc. Natl Acad. Sci. USA85, 6617–6621 (1988). ArticleCASPubMedPubMed Central Google Scholar
Horiuchi, M. & Caughey, B. Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state. EMBO J.18, 3193–3203 (1999). ArticleCASPubMedPubMed Central Google Scholar
Enari, M., Flechsig, E. & Weissmann, C. Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc. Natl Acad. Sci. USA98, 9295–9299 (2001). ArticleCASPubMedPubMed Central Google Scholar
Peretz, D. et al. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature412, 739–743 (2001). CASPubMed Google Scholar
Büeler, H. R. et al. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature356, 577–582 (1992). ArticlePubMed Google Scholar
Brandner, S. et al. Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proc. Natl Acad. Sci. USA93, 13148–13151 (1996). ArticleCASPubMedPubMed Central Google Scholar
Prusiner, S. B. et al. Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies. Proc. Natl Acad. Sci. USA90, 10608–10612 (1993). ArticleCASPubMedPubMed Central Google Scholar
Büeler, H. R. et al. Mice devoid of PrP are resistant to scrapie. Cell73, 1339–1347 (1993). ArticlePubMed Google Scholar
Korth, C. et al. Prion (PrPSc)-specific epitope defined by a monoclonal antibody. Nature390, 74–77 (1997). ArticleCASPubMed Google Scholar
Heppner, F. L. et al. Prevention of scrapie by transgenic anti-prion protein immunization. Science published online September 6 2001 (10.1126/science.1063093).