Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores (original) (raw)
- Letter
- Published: 18 July 1991
Nature volume 352, pages 241–244 (1991)Cite this article
- 289 Accesses
- 340 Citations
- 3 Altmetric
- Metrics details
Abstract
Inositol 1,4,5-trisphosphate (InsP3) functions as a second messenger to mobilize Ca2+ from intracellular reservoirs1. The release mechanism displays all-or-none characteristics2,3, that may account for other observations that the InsP3-induced mobilization of Ca2+ is quantal4–6. Quantal release may depend on the sensitivity of the InsP3 receptor being regulated by the Ca2+ concentration in the lumen of the endoplasmic reticulum7. We report here that the InsP3-sensitive store in hepatocytes discharges spontaneously when overloaded with Ca2+. The release, which is blocked by heparin, is preceded by an increasing sensitivity of the InsP3 receptor to endogenous InsP3, and is promoted by those sulphydryl reagents (oxidized glutathione and thimerosal) that induce Ca2+ oscillations in intact cells (ref. 8, and T. A. Rooney, D. C. Renard, E. J. Sass and A. P. Thomas, manuscript in preparation). This novel process could have a role in generating both Ca2+ oscillations and Ca2+ waves.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Berridge, M. J. & Irvine, R. F. Nature 341, 197–205 (1989).
Article ADS CAS Google Scholar - Miyazaki, S.-I. J. Cell Biol. 106, 345–353 (1988).
Article CAS Google Scholar - Parker, I. & Ivorra, I. Science 250, 977–979 (1990).
Article ADS CAS Google Scholar - Muallem, S., Pandol, S. J. & Beeker, T. G. J. biol. Chem. 264, 205–212 (1989).
CAS PubMed Google Scholar - Taylor, C. W. & Potter, B. V. L. Biochem. J. 266, 189–194 (1990).
Article CAS Google Scholar - Meyer, T. & Stryer, L. Proc. natn. Acad. Sci. U.S.A. 87, 3841–3845 (1990).
Article ADS CAS Google Scholar - Irvine, R. F. FEBS Lett. 263, 5–9 (1990).
Article CAS Google Scholar - Swann, K. FEBS Lett. 278, 175–178 (1991).
Article CAS Google Scholar - Gunter, T. E. & Pfeiffer, D. R. Am. J. Physiol. 258, C755–C786 (1990).
Article CAS Google Scholar - Ohnishi, S. T. J. Biochem. 86, 1147–1150 (1979).
Article CAS Google Scholar - Worley, P. F., Baraban, J. M., Supattapone, S., Wilson, V. S. & Snyder, S. H. J. biol. Chem. 262, 12132–12136 (1987).
CAS PubMed Google Scholar - Nunn, D. L. & Taylor, C. W. Biochem. J. 270, 227–232 (1990).
Article CAS Google Scholar - Becker, G. L., Fiskum, G. & Lehninger, A. L. J. biol. Chem. 255, 9009–9012 (1980).
CAS Google Scholar - Woods, N. M., Cuthbertson, K. S. R. & Cobbold, P. H. Nature 319, 600–602 (1986).
Article ADS CAS Google Scholar - Kawanishi, T., Blank, L. M., Harootunian, A. T., Smith, M. & Tsien, R. Y. J. biol. Chem. 264, 12859–12866 (1989).
CAS PubMed Google Scholar - Rooney, T. A., Sass, E. J. & Thomas, A. P. J. biol. Chem. 264, 17131–17141 (1989).
CAS PubMed Google Scholar - Jacob, R., Merritt, J. E., Hallam, T. J. & Rink, T. R. Nature 335, 40–45 (1988).
Article ADS CAS Google Scholar - Peres, A. FEBS Lett. 275, 213–216 (1990).
Article ADS CAS Google Scholar - Harootunian, A. T., Kao, J. P. Y. & Tsien, R. Y. Cold Spring Harb. Symp. quant. Biol. 53, 935–943 (1988).
Article CAS Google Scholar - Wakui, M., Potter, B. V. L. & Petersen, O. H. Nature 339, 317–320 (1989).
Article ADS CAS Google Scholar - Igusa, Y. & Miyazaki, S.-I. J. Physiol., Lond. 340, 611–632 (1983).
Article CAS Google Scholar - Woods, N. M., Dixon, C. J., Cuthbertson, K. S. R. & Cobbold, P. H. Cell Calcium 11, 353–360 (1990).
Article CAS Google Scholar - Kurtz, A. & Penner, R. Proc. natn. Acad. Sci. U.S.A. 86, 3423–3427 (1989).
Article ADS CAS Google Scholar - Stuenkel, E. L. & Ernst, S. A. Am. J. Physiol. 258, C289–C298 (1990).
Article CAS Google Scholar - Zhao, H., Khademazad, M. & Muallem, S. J. biol. Chem. 265, 14822–14827 (1990).
CAS PubMed Google Scholar - Finch, E. A., Turner, T. J. & Goldin, S. M. Science 252, 443–446 (1991).
Article ADS CAS Google Scholar - Iino, M. J. gen. Physiol. 95, 1103–1122 (1990).
Article CAS Google Scholar - Bezprozvanny, I., Watras, J. & Ehrlich, B. E. Nature 351, 751–754 (1991).
Article ADS CAS Google Scholar
Author information
Authors and Affiliations
- AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
Ludwig Missiaen & Michael J. Berridge - Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ, UK
Colin W. Taylor
Authors
- Ludwig Missiaen
You can also search for this author inPubMed Google Scholar - Colin W. Taylor
You can also search for this author inPubMed Google Scholar - Michael J. Berridge
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Missiaen, L., Taylor, C. & Berridge, M. Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores.Nature 352, 241–244 (1991). https://doi.org/10.1038/352241a0
- Received: 09 April 1991
- Accepted: 11 June 1991
- Issue Date: 18 July 1991
- DOI: https://doi.org/10.1038/352241a0