Transmission of chromosomal instability after plutonium α-particle irradiation (original) (raw)

Nature volume 355, pages 738–740 (1992)Cite this article

Abstract

WHEN investigating the biological effects of ionizing radiation on the haemopoietic system, a confounding problem lies in possible differences between the biological effects of sparsely ionizing, low linear energy transfer radiation such as X-, (β or Γ-rays, and densely ionizing, high linear energy transfer radiation such as α-particles. To address this problem we have developed novel techniques for studying haemopoietic cells irradiated with environmentally relevant doses of α-particles from a plutonium-238 source. Using a clonogenic culture system, cytogenetic aberrations in individual colonies of haemopoietic cells derived from irradiated stem cells have been studied. Exposure to α-particles (but not X-rays) produced a high frequency of non-clonal aberrations in the clonal descendants, compatible with α-emitters inducing lesions in stem cells that result in the transmission of chromosomal instability to their progeny. Such unexpected instability may have important implications for radiation leukaemogenesis.

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References

  1. Visser, J. W. M. & Van Bekkum, D. W. Expl Hematol. 18, 248–256 (1990).
    CAS Google Scholar
  2. Till, J. E. & McCulloch, E. A. Radiation Res. 14, 213–222 (1961).
    Article ADS CAS Google Scholar
  3. Lorimore, S. A., Pragnell, I. B., Eckmann, L. & Wright, E. G. Leuk. Res. 14, 481–489 (1990).
    Article CAS Google Scholar
  4. Goodhead, D. T. in Dosimetry of Ionizing Radiations Vol. 2 (eds Kase, K. R., Bjarngaard, B. E. & Attix, F. H.) 1–89 (Academic, New York, 1987).
    Book Google Scholar
  5. Visser, J., van den Engh, G., Williams, N. & Mulder, D. in Experimental Hematology Today (eds Baum, S. J. & Ledney, G. D.) 21–27 (Springer, New York, 1977).
    Google Scholar
  6. van den Engh, G., Visser, J. & Trask, B. in Experimental Hematology Today (eds Baum, S. J. & Ledney, G. D.) 19–26 (Springer, New York, 1979).
    Google Scholar
  7. Goodhead, D. T. Int. J. radiat. Biol. 56, 623–634 (1989).
    Article CAS Google Scholar
  8. Lloyd, D. C. & Edwards, A. A. in Radiation-Induced Chromosome Damage in Man (eds Ishihara, T. & Sasaki, M. S.) 23–49 (Liss, New York, 1983).
    Google Scholar
  9. Sinclair, W. K. Radiat. protec. Dosim. 13, 319–329 (1985).
    Article Google Scholar
  10. NCRP The Relative Biological Effectiveness of Radiations of Different Quality, NCRP Report 106 (National Council on Radiation Protection and Measurement, Bethesda, 1990).
  11. ICRP 1990 Recommendations of the International Commission on Radiological Protection, ICRP Publication 60 (Pergamon, Oxford, 1991).
  12. Aghamohammadi, S. Z., Goodhead, D. T. & Savage, J. R. K. Int. J. Radiat. Biol. 53, 909–915 (1988).
    Article CAS Google Scholar
  13. Black, D. (Chairman) Investigation of Possible Increased Incidence of Cancer in West Cumbria: Report of the Independent Advisory Group (HMSO, London, 1984).
  14. Bobrow, M. (Chairman) Committee on Medical Aspects of Radiation in the Environment (COMARE). Third Report (HMSO, London, 1989).
  15. UNSCEAR United Nations Scientific Committee on the Effects of Atomic Radiation: Report to the General Assembly (United Nations, New York, 1988).
  16. Goodhead, D. T., Bance, D. A., Stretch, A. & Wilkinson, R. E. Int. J. Radiat. Biol. 59, 195–210 (1991).
    Article CAS Google Scholar
  17. Amenomori, T. et al. Int. J. Cell Cloning 3, 133–142 (1985).
    Article CAS Google Scholar
  18. Piper, J. & Breckon, G. Cytogenet. Cell Genet. 50, 111–115 (1989).
    Article CAS Google Scholar

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Authors and Affiliations

  1. MRC Radiobiology Unit, Chilton, Didcot, Oxfordshire, 0X11 ORD, UK
    M. A. Kadhim, D. A. Macdonald, D. T. Goodhead, S. A. Lorimore, S. J. Marsden & E. G. Wright

Authors

  1. M. A. Kadhim
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  2. D. A. Macdonald
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  3. D. T. Goodhead
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  4. S. A. Lorimore
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  5. S. J. Marsden
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  6. E. G. Wright
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Kadhim, M., Macdonald, D., Goodhead, D. et al. Transmission of chromosomal instability after plutonium α-particle irradiation.Nature 355, 738–740 (1992). https://doi.org/10.1038/355738a0

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