Autoimmune diabetes as a consequence of locally produced interleukin-2 (original) (raw)

Nature volume 359, pages 547–549 (1992)Cite this article

Abstract

DURING cell differentiation in the thymus, self-reactive T cells can be generated. The majority of these seem to be deleted after intrathymic encounter with the relevant autoantigen1. As all self antigens are unlikely to be present in the thymus, some autoreactive T cells may escape censorship. Here we study the fate of these cells using transgenic mice expressing the class I molecule H–2Kb(Kb) in the insulin-producing β -cells of the pancreas2,3. These mice were crossed with mice transgenic for genes encoding a Kb-specific T-cell antigen receptor (TCR)4 which could be detected using a clonotype-specific monoclonal antibody5. Although T cells expressing the highest level of transgenic TCR were deleted intrathymi-cally in double-transgenic mice, Kb-specific T cells were detected in the periphery. These cells caused the rejection of Kb-expressing skin grafts, but ignored islet Kb antigens even after priming. But when double-transgenic mice were crossed with transgenic mice expressing the lymphokine interleukin-2 in the pancreatic β-cells6, there was a rapid onset of diabetes. These results indicate that autoreactive T cells that ignore self antigens may cause autoimmune diabetes when provided with exogenous 'help' in the form of interleukin-2.

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute of Medical Research, Post Office, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
    William R. Heath, Janette Allison, Matthias W. Hoffmann & Jacques F. A. P. Miller
  2. Institut fur Immunologie und Genetik, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, 1, Germany
    Günther Schönrich, Günter Hämmerling & Bernd Arnold

Authors

  1. William R. Heath
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  2. Janette Allison
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  3. Matthias W. Hoffmann
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  4. Günther Schönrich
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  5. Günter Hämmerling
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  6. Bernd Arnold
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  7. Jacques F. A. P. Miller
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Heath, W., Allison, J., Hoffmann, M. et al. Autoimmune diabetes as a consequence of locally produced interleukin-2.Nature 359, 547–549 (1992). https://doi.org/10.1038/359547a0

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