High-affinity IgE receptor on eosinophils is involved in defence against parasites (original) (raw)

Nature volume 367, pages 183–186 (1994)Cite this article

An Erratum to this article was published on 31 March 1994

Abstract

PARASITIC infections are often associated with eosinophilia and high levels of immunoglobulin E (IgE). This observation has led to speculation that eosinophils and IgE may act together in the immune response against parasites. In support of this hypothesis, IgE and eosinophils participate in cytotoxic reactions directed against Schistosoma mansoni larvae _in vitro_1,2. Furthermore, epidemiological studies have shown an inverse correlation between levels of specific IgE and rates of infection with _Schistosoma_3–5. The low-affinity IgE receptor (FcεRII/CD23) was first incriminated in eosinophil activation6,7. The fact that the high-affinity IgE receptor (FcεRI)8,9 is not only expressed on mast cells and basophils but also on Langerhans cells10,11 led us to investigate the presence of FcεRI on eosinophils. Here we show that FcεRI is expressed on eosinophils from hypereosinophilic patients, is involved in eosinophil degranulation, and participates in eosinophil-mediated cytotoxicity against S. mansoni. Our results indicate that FcεRI may play a major part in immune defence against parasites.

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Author notes

  1. Monique Capron: To whom correspondence should be addressed

Authors and Affiliations

  1. Centre d'lmmunologie et de Biologie Parasitaire, Unite Mixte INSERM U167-CNRS624, Institut Pasteur, 1 rue du Professeur A. Calmette, BP 245, 59019, Lille, France
    Abdelillah Soussi Gounni, Bouchaïb Lamkhioued, Yoïchi Tanaka, André Capron & Monique Capron
  2. Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, 20852, USA
    Kenichi Ochiai & Jean-Pierre Kinet
  3. Service de Dermatologie A, Centre Hospitalier Regional Universitaire, 59000, Lille, France
    Emmanuel Delaporte

Authors

  1. Abdelillah Soussi Gounni
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  2. Bouchaïb Lamkhioued
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  3. Kenichi Ochiai
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  4. Yoïchi Tanaka
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  5. Emmanuel Delaporte
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  6. André Capron
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  7. Jean-Pierre Kinet
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  8. Monique Capron
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Soussi Gounni, A., Lamkhioued, B., Ochiai, K. et al. High-affinity IgE receptor on eosinophils is involved in defence against parasites.Nature 367, 183–186 (1994). https://doi.org/10.1038/367183a0

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