A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin (original) (raw)
- Letter
- Published: 20 July 1995
- P. David Jackson2,
- Yoshiki Sasai3,
- Bin Lu3,
- Eddy M. De Robertis3,
- F. Michael Hoffmann2 &
- …
- Edwin L. Ferguson1
Nature volume 376, pages 249–253 (1995)Cite this article
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Abstract
DORSAL-VENTRAL patterning within the ectoderm of the Drosophila embryo requires seven zygotic genes, including _short gastrulation (sog)_1. Here we demonstrate that sog, which is expressed in the ventrolateral region of the embryo that gives rise to the nerve cord2, is functionally homologous to the chordin gene of Xenopus, which is expressed in the dorsal blastopore lip of the embryo and in dorsal mesoderm, in particular the notochord3. We show by injections of messenger RNA that both sog and chordin can promote ventral development in Drosophila, and that sog, like _chordin_3, can promote dorsal development in Xenopus. In Drosophila, sog antagonizes the dorsalizing effects of _decapentaplegic (dpp)_1,2,4, a member of the transforming growth factor-β family. One of the dpp homologues in vertebrates, bmp-4, is expressed ventrally in _Xenopus_5 and promotes ventral development6,7. We show that dpp can promote ventral fates in Xenopus, and that injection of sog mRNA counteracts the ventralizing effects of dpp. These results suggest the molecular conservation of dorsoventral patterning mechanisms during evolution.
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Authors and Affiliations
- Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, Illinois, 60637, USA
Scott A. Holley & Edwin L. Ferguson - McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, Wisconsin, 53706, USA
P. David Jackson & F. Michael Hoffmann - Department of Biological Chemistry and Howard Hughes Medical Institute, University of California, Los Angeles, California, 90024, USA
Yoshiki Sasai, Bin Lu & Eddy M. De Robertis
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- Scott A. Holley
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Holley, S., Jackson, P., Sasai, Y. et al. A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.Nature 376, 249–253 (1995). https://doi.org/10.1038/376249a0
- Received: 14 March 1995
- Accepted: 30 May 1995
- Issue Date: 20 July 1995
- DOI: https://doi.org/10.1038/376249a0