A cortical neuropeptide with neuronal depressant and sleep-modulating properties (original) (raw)
- Letter
- Published: 16 May 1996
- José R. Criado2,
- Óscar Prospero-Garcia2,
- Kaare M. Gautvik1,
- Paul Schweitzer2,
- Patria E. Danielson1,
- Charles L. M. Dunlop1,
- George R. Siggins2,
- Steven J. Henriksen2 &
- …
- J. Gregor Sutcliffe1
Nature volume 381, pages 242–245 (1996)Cite this article
- 999 Accesses
- 321 Citations
- 9 Altmetric
- Metrics details
Abstract
ACETYLCHOLINE (ACh) plays a key role in the transitions between the different phases of sleep1: Slow-wave sleep requires low ACh concentrations in the brain, whereas rapid-eye-movement (REM) sleep is associated with high levels of ACh. Also, these phases of sleep are differentially sensitive to a number of endogenous neuropeptides and cytokines, including somatostatin, which has been shown to increase REM sleep without significantly affecting other phases2. Here we report the cloning and initial characterization of cortistatin, a neuropeptide that exhibits strong structural similarity to somatostatin, although it is the product of a different gene. Administration of cortistatin depresses neuronal electrical activity but, unlike somatostatin, induces low-frequency waves in the cerebral cortex and antagonizes the effects of acetylcholine on hippocampal and cortical measures of excitability. This suggests a mechanism for cortical synchronization related to sleep.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Similar content being viewed by others
References
- Shiromani, P. J., Gillin, J. C. & Henriksen, S. J. A. Rev. Pharmac. Toxicol. 27, 137–56 (1987).
Article CAS Google Scholar - Borbely, A. A. & Tobler, I. Physiol. Rev. 69, 605–670 (1989).
Article CAS Google Scholar - Glushankov, P. et al. Proc. natn. Acacf. Sci. U.S.A. 81, 6662–6666 (1984).
Article ADS Google Scholar - Veber, D. F. et al. Nature 280, 512–514 (1979).
Article ADS CAS Google Scholar - Erlander, M. G. et al. Neuron 7, 91–100 (1991).
Article CAS Google Scholar - Schonbrunn, A. H. & Tashijan, A. J. R., J. biol. Chem. 235, 6473–6483 (1978).
Google Scholar - Halliwell, J. V. & Adams, P. R. Brain Res. 250, 71–92 (1982).
Article CAS Google Scholar - Moore, S. D. et al. Science 239, 278–280 (1988).
Article ADS CAS Google Scholar - Schweitzer, P., Madamba, S. & Siggins, G. R. Nature 346, 464–466 (1990).
Article ADS CAS Google Scholar - Andersen, P., Bliss, T. V. P. & Skrede, K. K. Expl Brain Res. 13, 208–221 (1971).
CAS Google Scholar - Danguir, J. Brain Res. 367, 26–30 (1986).
Article CAS Google Scholar - Steriade, M., McCormick, D. A. & Sejnowski, T. J. Science 262, 679–685 (1993).
Article ADS CAS Google Scholar - Andersen, P., Eccles, J. C. & Løyning, Y. J. Neurophysiol. 27, 607–619 (1964).
Google Scholar - Kandel, E. R. & Spencer, W. A. J. Neurophysiol. 24, 243–259 (1961).
Article CAS Google Scholar - Steffensen, S. & Henriksen, S. J. Brain Res. 538, 46–53 (1991).
Article CAS Google Scholar - Maurer, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4815–4817 (1982).
Article ADS CAS Google Scholar - Scharfman, H. E. & Schwartzkroin, P. A. Brain Res. 493, 205–211 (1989).
Article CAS Google Scholar - deLecea, L. et al. Molec. Brain Res. 25, 286–296 (1994).
Article CAS Google Scholar - Schweitzer, P. et al. J. Neurosci. 13, 2033–2049 (1993).
Article CAS Google Scholar - Prospero-Garcia, O., Criado, J. R. & Henriksen, S. J. Pharmac. Biochem. Behav. 49, 413 (1994).
Article CAS Google Scholar - Steffensen, S. C., Campbell, I. L. & Henriksen, S. J. Brain Res. 652, 149 (1994).
Article CAS Google Scholar
Author information
Authors and Affiliations
- Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, 92037, USA
Luis de Lecea, Kaare M. Gautvik, Patria E. Danielson, Charles L. M. Dunlop & J. Gregor Sutcliffe - Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, 92037, USA
José R. Criado, Óscar Prospero-Garcia, Paul Schweitzer, George R. Siggins & Steven J. Henriksen
Authors
- Luis de Lecea
You can also search for this author inPubMed Google Scholar - José R. Criado
You can also search for this author inPubMed Google Scholar - Óscar Prospero-Garcia
You can also search for this author inPubMed Google Scholar - Kaare M. Gautvik
You can also search for this author inPubMed Google Scholar - Paul Schweitzer
You can also search for this author inPubMed Google Scholar - Patria E. Danielson
You can also search for this author inPubMed Google Scholar - Charles L. M. Dunlop
You can also search for this author inPubMed Google Scholar - George R. Siggins
You can also search for this author inPubMed Google Scholar - Steven J. Henriksen
You can also search for this author inPubMed Google Scholar - J. Gregor Sutcliffe
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
de Lecea, L., Criado, J., Prospero-Garcia, Ó. et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties.Nature 381, 242–245 (1996). https://doi.org/10.1038/381242a0
- Received: 05 December 1995
- Accepted: 21 March 1996
- Issue Date: 16 May 1996
- DOI: https://doi.org/10.1038/381242a0