The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1 (original) (raw)

Nature volume 382, pages 833–835 (1996)Cite this article

An Erratum to this article was published on 21 November 1996

Abstract

APUTATIVE chemokine receptor that we previously cloned and termed LESTR1 has recently been shown to function as a co-receptor (termed fusin) for lymphocyte-tropic HIV-1 strains2. Cells expressing CD4 became permissive to infection with T-cell-line-adapted HIV-1 strains of the syncytium-inducing phenotype after transfection with LESTR/fusin complementary DNA. We report here the identification of a human chemokine of the CXC type, stromal cell-derived factor 1 (SDF-1), as the natural ligand for LESTR/fusin, and we propose the term CXCR-4 for this receptor, in keeping with the new chemokine-receptor nomenclature. SDF-1 activates Chinese hamster ovary (CHO) cells transfected with CXCR-4 cDNA as well as blood leukocytes and lymphocytes. In cell lines expressing CXCR-4 and CD4, and in blood lymphocytes, SDF-1 is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains, whereas the CC chemokines RANTES, MIP-lα and MIP-1β, which were shown previously to prevent infection with primary, monocyte-tropic viruses3, are inactive. In combination with CC chemokines, which block the infection with monocyte/macrophage-tropic viruses, SDF-1 could help to decrease virus load and prevent the emergence of the syncytium-inducing viruses which are characteristic of the late stages of AIDS4.

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Authors and Affiliations

  1. Unité d'lmmunologie Virale, Institut Pasteur, 75724, Paris, Cedex 15, France
    Estelle Oberlin, Ali Amara, Franc˛oise Bachelerie, Christine Bessia, Jean-Louis Virelizier & Fernando Arenzana-Seisdedos
  2. Laboratoire Rétrovirus et Transfert Génetique, Institut Pasteur, 75724, Paris, Cedex 15, France
    Olivier Schwartz & Jean-Michel Heard
  3. Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, British Columbia, V6T1Z3, Canada
    Ian Clark-Lewis
  4. Theodor-Kocher Institute, University of Bern, PO Box 3000, Bern, 9, Switzerland
    Daniel F. Legler, Marcel Loetscher, Marco Baggiolini & Bernhard Moser

Authors

  1. Estelle Oberlin
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  2. Ali Amara
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  3. Franc˛oise Bachelerie
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  4. Christine Bessia
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  5. Jean-Louis Virelizier
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  6. Fernando Arenzana-Seisdedos
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  7. Olivier Schwartz
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  8. Jean-Michel Heard
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  9. Ian Clark-Lewis
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  10. Daniel F. Legler
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  11. Marcel Loetscher
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  12. Marco Baggiolini
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  13. Bernhard Moser
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Oberlin, E., Amara, A., Bachelerie, F. et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1.Nature 382, 833–835 (1996). https://doi.org/10.1038/382833a0

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