Induction of cell death by endogenous nerve growth factor through its p75 receptor (original) (raw)

Nature volume 383, pages 166–168 (1996)Cite this article

Abstract

DURING development, neuronal survival is regulated by the limited availability of neurotrophins, which are proteins of the nerve growth factor (NGF) family. Activation of specific trk tyrosine kinase receptors by the neurotrophins blocks programmed cell death. The _trk_A-specific ligand NGF has also been shown to activate the non-tyrosine kinase receptor p75, a member of the tumour necrosis factor (TNF) receptor and Fas (APO-1/CD95) family. Here we report that, early in development, endogenous NGF causes the death of retinal neurons that express p75 but not _trk_A. These results indicate that, as with cells of the immune system, the death of neurons in the central nervous system can also be induced by ligands, and that the effect of NGF on cell fate depends on the type of receptor expressed by developing neurons.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

References

  1. Oppenheim, R. W. Annu. Rev. Neurosci. 14, 453–501 (1991).
    Article CAS Google Scholar
  2. Lewin, G. R. & Barde, Y.-A. Annu. Rev. Neurosci. 19, 289–317 (1996).
    Article CAS Google Scholar
  3. Barbacid, M. J. Neurobiol. 25, 1386–1403 (1994).
    Article CAS Google Scholar
  4. Blaschke, A. J., Staley, K. & Chun, J. Development 122, 1165–1174 (1996).
    CAS PubMed Google Scholar
  5. Sulston, J. & Horvitz, H. R. Dev. Biol. 56, 110–156 (1977).
    Article CAS Google Scholar
  6. Carter, B. D. et al. Science 272, 542–545 (1996).
    Article ADS CAS Google Scholar
  7. von Bartheld, C. S., Heuer, J. G. & Bothwell, M. J. Comp. Neurol. 310, 103–129 (1991).
    Article CAS Google Scholar
  8. Cuadros, M. A. & Rios, A. Anat Embryol. 178, 543–551 (1988).
    Article CAS Google Scholar
  9. Rohrer, H. et al. Development 103, 545–552 (1988).
    CAS PubMed Google Scholar
  10. Leist, M. et al. J. Immunol. 153, 1778–1788 (1994).
    CAS PubMed Google Scholar
  11. Bovolenta, P. et al. J. Neurosci. 16, 4402–4410 (1996).
    Article CAS Google Scholar
  12. Weskamp, G. & Reichardt, L. F. Neuron 6, 649–663 (1991).
    Article CAS Google Scholar
  13. von Bartheld, C. S. et al. Neuron 12, 639–654 (1994).
    Article CAS Google Scholar
  14. Sendtner, M., Holtmann, B., Kolbeck, R., Thoenen, H. & Barde, Y.-A. Nature 360, 757–759 (1992).
    Article ADS CAS Google Scholar
  15. Ernfors, P., Henschen, A., Olson, L. & Persson, H. Neuron 2, 1605–1613 (1989).
    Article CAS Google Scholar
  16. Rabizadeh, S. et al. Science 261, 345–348 (1993).
    Article ADS CAS Google Scholar
  17. Barrett, G. L. & Bartlett, P. F. Proc. Natl Acad. Sci. USA 91, 6501–6505 (1994).
    Article ADS CAS Google Scholar
  18. Graham, A., Francis-West, P., Brickell, P. & Lumsden, A. Nature 372, 684–686 (1994).
    Article ADS CAS Google Scholar
  19. Ghosh, A. & Shatz, C. J. Science 255, 1441–1443 (1992).
    Article ADS CAS Google Scholar
  20. Allendoerfer, K. L. et al. J. Neurosci. 14, 1795–1811 (1994).
    Article CAS Google Scholar
  21. Hamburger, V. & Hamilton, H. J. Morphol. 88, 49–92 (1951).
    Article CAS Google Scholar
  22. Ebendal, T., Larhammar, D. & Persson, H. EMBO J. 5, 1483–1487 (1986).
    Article CAS Google Scholar
  23. Schröpel, A., von Schack, D., Dechant, G. & Barde, Y.-A. Mol. Cell. Neurosci. 6, 544–556 (1995).
    Article Google Scholar
  24. Dugaiczyk, A. et al. Biochemistry 22, 1605–1613 (1983).
    Article CAS Google Scholar
  25. Gaese, F., Kolbeck, R. & Barde, Y.-A. Development 120, 1613–1619 (1994).
    CAS PubMed Google Scholar

Download references

Author information

Author notes

  1. Alfredo Rodríguez-Tébar: Cajal Institute, CSIC, Doctor Arce 37, E-28002 Madrid, Spain

Authors and Affiliations

  1. Department of Neurobiochemistry, Max-Planck Institute for Psychiatry, 82152, Planegg-Martinsried, Germany
    José María Frade, Alfredo Rodríguez-Tébar & Yves-Alain Barde

Authors

  1. José María Frade
    You can also search for this author inPubMed Google Scholar
  2. Alfredo Rodríguez-Tébar
    You can also search for this author inPubMed Google Scholar
  3. Yves-Alain Barde
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

María Frade, J., Rodríguez-Tébar, A. & Barde, YA. Induction of cell death by endogenous nerve growth factor through its p75 receptor.Nature 383, 166–168 (1996). https://doi.org/10.1038/383166a0

Download citation

This article is cited by