Induction of cell death by endogenous nerve growth factor through its p75 receptor (original) (raw)
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- Published: 12 September 1996
Nature volume 383, pages 166–168 (1996)Cite this article
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Abstract
DURING development, neuronal survival is regulated by the limited availability of neurotrophins, which are proteins of the nerve growth factor (NGF) family. Activation of specific trk tyrosine kinase receptors by the neurotrophins blocks programmed cell death. The _trk_A-specific ligand NGF has also been shown to activate the non-tyrosine kinase receptor p75, a member of the tumour necrosis factor (TNF) receptor and Fas (APO-1/CD95) family. Here we report that, early in development, endogenous NGF causes the death of retinal neurons that express p75 but not _trk_A. These results indicate that, as with cells of the immune system, the death of neurons in the central nervous system can also be induced by ligands, and that the effect of NGF on cell fate depends on the type of receptor expressed by developing neurons.
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Author notes
- Alfredo Rodríguez-Tébar: Cajal Institute, CSIC, Doctor Arce 37, E-28002 Madrid, Spain
Authors and Affiliations
- Department of Neurobiochemistry, Max-Planck Institute for Psychiatry, 82152, Planegg-Martinsried, Germany
José María Frade, Alfredo Rodríguez-Tébar & Yves-Alain Barde
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- José María Frade
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María Frade, J., Rodríguez-Tébar, A. & Barde, YA. Induction of cell death by endogenous nerve growth factor through its p75 receptor.Nature 383, 166–168 (1996). https://doi.org/10.1038/383166a0
- Received: 20 June 1996
- Accepted: 30 July 1996
- Issue Date: 12 September 1996
- DOI: https://doi.org/10.1038/383166a0