Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET (original) (raw)
- Letter
- Published: 13 February 1997
- Tetsuya Suhara2,
- Kazutoshi Suzuki2,
- Kaoru Kobayashi2,
- Osamu Inoue2,
- Omi Terasaki1,2,
- Yasuhiro Someya1,2,
- Takeshi Sassa1,2,
- Yasuhiko Sudo2,
- Eisuke Matsushima1,
- Masaomi Iyo2,
- Yukio Tateno2 &
- …
- Michio Toru1
Nature volume 385, pages 634–636 (1997)Cite this article
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Abstract
Schizophrenia is believed to involve altered activation of dopamine receptors, and support for this hypothesis conies from the antipsychotic effect of antagonists of the dopamine D2 receptor (D2R)1. D2R is expressed most highly in the striatum, but most of the recent positron emission tomography (PET) studies have failed to show any change in D2R densities in the striatum of schizophrenics2–5, raising the possibility that other receptors may also be involved. In particular, the dopamine D1 receptor (D1R), which is highly expressed in the prefrontal cortex6, has been implicated in the control of working memory7,8, and working memory dysfunction is a prominent feature of schizophrenia9. We have therefore used PET to examine the distribution of D1R and D2R in brains of drug-naive or drug-free schizophrenic patients. Although no differences were observed in the striatum relative to control subjects, binding of radioligand to D1R was reduced in the prefrontal cortex of schizophrenics. This reduction was related to the severity of the negative symptoms (for instance, emotional withdrawal) and to poor performance in the Wisconsin Card Sorting Test10. We propose that dysfunction of D1R signalling in the prefrontal cortex may contribute to the negative symptoms and cognitive deficits seen in schizophrenia.
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Authors and Affiliations
- Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113, Japan
Yoshiro Okubo, Omi Terasaki, Yasuhiro Someya, Takeshi Sassa, Eisuke Matsushima & Michio Toru - Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, 263, Japan
Yoshiro Okubo, Tetsuya Suhara, Kazutoshi Suzuki, Kaoru Kobayashi, Osamu Inoue, Omi Terasaki, Yasuhiro Someya, Takeshi Sassa, Yasuhiko Sudo, Masaomi Iyo & Yukio Tateno
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Okubo, Y., Suhara, T., Suzuki, K. et al. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET.Nature 385, 634–636 (1997). https://doi.org/10.1038/385634a0
- Received: 15 August 1996
- Accepted: 04 December 1996
- Issue Date: 13 February 1997
- DOI: https://doi.org/10.1038/385634a0