Temporal dynamics of brain activation during a working memory task (original) (raw)

Nature volume 386, pages 604–608 (1997)Cite this article

Abstract

Working memory is responsible for the short-term storage and online manipulation of information necessary for higher cognitive functions, such as language, planning and problem-solving1,2. Traditionally, working memory has been divided into two types of processes: executive control (governing the encoding manipulation and retrieval of information in working memory) and active maintenance (keeping information available 'online'). It has also been proposed that these two types of processes may be subserved by distinct cortical structures, with the prefrontal cortex housing the executive control processes, and more posterior regions housing the content-specific buffers (for example verbal versus visuospatial) responsible for active maintenance3,4. However, studies in non-human primates suggest that dorsolateral regions of the prefrontal cortex may also be involved in active maintenance5–8. We have used functional magnetic resonance imaging to examine brain activation in human subjects during performance of a working memory task. We used the temporal resolution of this technique to examine the dynamics of regional activation, and to show that prefrontal cortex along with parietal cortex appears to play a role in active maintenance.

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Authors and Affiliations

  1. Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania, 15213, USA
    Jonathan D. Cohen & Todd S. Braver
  2. Department of Psychia try, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, Pennsylvania, 15213, USA
    Jonathan D. Cohen, William M. Perlstein & Leigh E. Nystrom
  3. Department of Radiology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, Pennsylvania, 15213, USA
    Douglas C. Noll
  4. Department of Psychology, University of Michigan, 525 East University, Ann Arbor, Michigan, 48109, USA
    John Jonides & Edward E. Smith

Authors

  1. Jonathan D. Cohen
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  2. William M. Perlstein
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  3. Todd S. Braver
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  4. Leigh E. Nystrom
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  5. Douglas C. Noll
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  6. John Jonides
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  7. Edward E. Smith
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Cohen, J., Perlstein, W., Braver, T. et al. Temporal dynamics of brain activation during a working memory task.Nature 386, 604–608 (1997). https://doi.org/10.1038/386604a0

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