Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection (original) (raw)
References
1. Ho, D. D., Moudgil, T. & Alam, M. Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. N. Engl. J. Med. 321, 1621-1625 (1989). Coombs, R. W. et al. Plasma viremia in human immunodeficiency virus infection. N. Engl. J. Med. 2. 3. 321, 1626-1631 (1989). Piatak, M. Jr. et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259, 1749-1754 (1993). 4. Mellors, J. W. et al. Prognosis in HIV- 1 infection predicted by the quantity of virus in plasma. Science 272, 1167-1170(1986). 5. Schnittman, S. M. et al. The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4. Science 245, 305-308 (1989). 6. Bukrinsky, M. L, Stanwick, T. L., Dempsey, M. P. & Stevenson, M. Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection. Science 254, 423-427 (1991). 7. Bagasra, O., Hauptman, S. P., Lischner, H. W., Sachs, M. & Pomerantz, R. J. Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction. N. Engl. J. Med. 326, 1385-1391 (1992). 8. Patterson, B. K. et al. Detection of HIV- 1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry. Science 260, 976-979 (1993). 9. Embretson, J. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359-362 (1993). 1 0. Pantaleo, G. et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355-358 (1993). 11. Harper, M. E., Marselle, L. M., Gallo, R. C. & Wong-Staal, R Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization. Proc. Natl Acad. Sci. USA 83, 772-776 (1986). 12. Seshamma, T., Bagasra, O., Trono, D., Baltimore, D. & Pomerantz, R. J. Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1. Proc. Natl Acad. Sci. USA 89, 10663-10667 (1992). 13. Adams, M. et al. Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. Proc. Natl Acad. Sci. USA 91, 3862-3866(1994). 14. Haase, A. T. et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274, 985-989 (1996). 15. Ho, D. D. et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-126 (1995). 16. Wei, X. et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373,117-122 (1995). 17. Perelson, A. S., Neumann, A. U., Markowitz, M., Leonard, J. M. & Ho, D. D. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, viral generation time. Science 271, 1582-1586 (1986). 18. Coffin, J. M. HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489 (1995). 19. Zack, J. A. et al. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61, 213-222 (1990). 20. Bukrinsky, M. I. etal. Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proc. Natl Acad. Sci. USA 89, 6580-6584 (1992). 21. Chun, T.-W. et al. Fate of HIV-1-infected T cells in vivo: Rates of transition to stable latency. Nature Med. 1, 1284-1290 (1995). 22. Pauza, C. D. Two bases are deleted from the termini of HIV-1 linear DNA during integrative recombination. Virology 179, 886-889 (1990). 23. Brown, P. O., Bowerman, B., Varmus, H. E. & Bishop, J. M. Retroviral integration: Structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc. Natl Acad. Sci. USA 86,2525-2529(1989). 24. Dimitrov, D. S. et al. Quantitation of human immunodeficiency virus type 1 infection kinetics. /. Virol. 67,2182-2190(1993). 25. Gartner, S. et al. The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233, 215-219 (1986). 26. Dickover, R. E. et al. Decreases in unintegrated HIV DNA are associated with antiretroviral therapy in AIDS patients. /. Acq. Imm. Def. Syndr. 5, 31-36 (1992). 27. Michie, C. A., McLean, A., Alcock, C. & Beverley, P. C. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360, 264-265 (1992). 28. Patel, S. S., Duby, A. D., Tiele, D. L. & Lipsky, P. E. Phenotypic and functional characterization of human T cell clones. /. Immunol. 141, 3726-3736 (1988). 29. Myers, L. A., McQuay, L. J. & Hollinger, F. B. Dilution assay statistics. /. Clin. Microbiol. 32, 732-739 (1994). 30. Perelson, A. S. et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387, 188-191 (1997).