Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene (original) (raw)

References

  1. Choi, D. W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623–634 (1988).
    Article CAS Google Scholar
  2. Coyle, J. T. & Puttfarcken, P. Oxidative stress, glutmate, and neurodegenerative disorders. Science 262, 689–695 (1993).
    Article ADS CAS Google Scholar
  3. Schwarzschild, M. A., Cole, R. L. & Hyman, S. E. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci. 17, 3455–3466 (1997).
    Article CAS Google Scholar
  4. Kawasaki, H. et al. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem. 272, 18518–18521 (1997).
    Article CAS Google Scholar
  5. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J. & Greenberg, M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326–1331 (1995).
    Article ADS CAS Google Scholar
  6. Martin, J. H., Mohit, A. A. & Miller, C. A. Developmental expression in the mouse nervous system of the p493F12 SAP kinase. Brain Res. Mol. Brain Res. 35, 47–57 (1996).
    Article CAS Google Scholar
  7. Gupta, S. et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15, 2760–2770 (1996).
    Article CAS Google Scholar
  8. Kyriakis, J. M. et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156–160 (1994).
    Article ADS CAS Google Scholar
  9. Derijard, B. et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025–1037 (1994).
    Article CAS Google Scholar
  10. Whitmarsh, A. J. & Davis, R. J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med. 74, 589–607 (1996).
    Article CAS Google Scholar
  11. Derijard, B. et al. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267, 682–685 (1995).
    Article ADS CAS Google Scholar
  12. Nishina, H. et al. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385, 350–353 (1997).
    Article ADS CAS Google Scholar
  13. Sanchez, I. et al. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372, 794–798 (1994).
    Article ADS CAS Google Scholar
  14. Yang, D. et al. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of JNK activation and defects in AP-1 transcriptional activity. Proc. Natl Acad. Sci. USA 94, 3004–3009 (1997).
    Article ADS CAS Google Scholar
  15. Tournier, C., Whitmarsh, A. J., Cavanagh, J., Barrett, T. & Davis, R. J. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc. Natl Acad. Sci. USA 94, 7337–7342 (1997).
    Article ADS CAS Google Scholar
  16. Gupta, S., Campbell, D., Derijard, B. & Davis, R. J. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389–393 (1995).
    Article ADS CAS Google Scholar
  17. Ben-Ari, Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14, 375–403 (1985).
    Article CAS Google Scholar
  18. Ferkany, J. W., Zaczek, R. & Coyle, J. T. The mechanism of kainic acid neurotoxicity. Nature 308, 561–562 (1984).
    Article ADS CAS Google Scholar
  19. Morgan, J. I. & Curran, T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu. Rev. Neurosci. 14, 421–451 (1991).
    Article CAS Google Scholar
  20. Kasof, G. M. et al. Kanic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats. J. Neurosci. 15, 4238–4249 (1995).
    Article CAS Google Scholar
  21. Morgan, J. I., Cohen, D. R., Hempstead, J. L. & Curran, T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237, 192–197 (1987).
    Article ADS CAS Google Scholar
  22. Berger, M. & Ben-Ari, Y. Autoradiographic visualization of [3H]kainic acid receptor subtypes in the rat hippocampus. Neurosci. Lett. 39, 237–242 (1983).
    Article CAS Google Scholar
  23. Westbrook, G. L. & Lothman, E. W. Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity. Brain Res. 273, 97–109 (1983).
    Article CAS Google Scholar
  24. Rincn, M. & Flavell, R. A. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 13, 4370–4381 (1994).
    Article Google Scholar
  25. Rothman, S. M., Thurston, J. H. & Hauhart, R. E. Delayed neurotoxicity of excitatory amino acids in vitro. Neuroscience 22, 471–480 (1987).
    Article CAS Google Scholar
  26. Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P. & Lipton, S. A. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl Acad. Sci. USA 92, 7162–7166 (1995).
    Article ADS CAS Google Scholar
  27. Mohit, A. A., Martin, J. H. & Miller, C. A. p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron 14, 67–78 (1995).
    Article CAS Google Scholar
  28. Lipton, S. A. & Rosenberg, P. A. Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613–622 (1994).
    Article CAS Google Scholar
  29. Rothman, S. M. & Olney, J. W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19, 105–111 (1986).
    Article CAS Google Scholar
  30. Tsirka, S. E., Gualandris, A., Amaral, D. G. & Strickland, S. Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature 377, 340–344 (1995).
    Article ADS CAS Google Scholar

Download references