Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion (original) (raw)
References
Geppert, M.et al. The role of Rab3A in neurotransmitter release. Nature369, 493–497 (1994). ArticleADSCAS Google Scholar
Holz, R. W., Brondyk, W. H., Senter, R. A., Kuizon, L. & Macara, I. G. Evidence for the involvement of Rab3A in Ca2+-dependent exocytosis from adrenal chromaffin cells. J. Biol. Chem.269, 10229–10234 (1994). CASPubMed Google Scholar
Johannes, L.et al. The GTPase Rab3a negatively controls calcium-dependent exocytosis in neuroendrocrine cels. EMBO J.13, 2029–2037 (1994). ArticleCAS Google Scholar
Geppert, M., Goda, Y., Stevens, C. F. & Südhof, T. C. Rab3A regulates a late step in synaptic vesicle fusion. Nature387, 810–814 (1997). ArticleADSCAS Google Scholar
Castillo, P. E., Janz, R., Südhof, T. C., Tzounopoulos, T., Malenka, R. C. & Nicoll, R. A. Rab3A is essential for mossy fibre long-term potentiation in the hippocampus. Nature388, 590–593 (1997). ArticleADSCAS Google Scholar
Burstein, E. S., Brondyk, W. H., Macara, I. G., Kaibuchi, K. & Takai, Y. Regulation of the GTPase cycle of the neuronally expressed Ras-like GTP-bindign protein Rab3A. J. Biol. Chem.268, 22247–22250 (1993). CASPubMed Google Scholar
Fischer von Mollard, G., Stahl, B., Khokhlatchev, A., Südhof, T. C. & Jahn, R. Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis. J. Biol. Chem.269, 10971–10974 (1994). CASPubMed Google Scholar
Südhof, T. C. Function of Rab3A GDP/GTP exchange. Neuron18, 519–522 (1997). Article Google Scholar
Bourne, H. R., Sanders, D. A. & McCormick, F. The GTPase superfamily: a conserved switch for diverse cel functions. Nature348, 125–132 (1990). ArticleADSCAS Google Scholar
Nuoffer, C. & Balch, W. E. GTPases: multifunctional molecular switches regulating vesicular traffic. Annu. Rev. Biochem.63, 949–990 (1994). ArticleCAS Google Scholar
Shirataki, H.et al. Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Mol. Cell. Biol.13, 2061–2068 (1993). ArticleCAS Google Scholar
Li, C.et al. Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C. Neuron13, 885–898 (1994). ArticleCAS Google Scholar
Stahl, B., Chou, J. H., Li, C., Südhof, T. C. & Jahn, R. Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras. EMBO J.15, 1799–1809 (1996). ArticleCAS Google Scholar
Vojtek, A. B., Hollenberg, S. M. & Cooper, J. A. Mammalian ras interacts directly with the serin/threonine kinase raf. Cell74, 205–214 (1993). ArticleCAS Google Scholar
Südhof, T. C. & Rizo, J. Synaptotagmins: C2-domain proteins that regulate membrane traffic. Neuron17, 379–388 (1996). Article Google Scholar
Weisman, L. S. & Wickner, W. Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. J. Biol. Chem.267, 618–623 (1992). CASPubMed Google Scholar
Yamamoto, A.et al. Novel PI(4)P 5-kinase homologue, Fablp, essential for normal vacuole function and morphology in yeast. Mol. Biol. Cell6, 525–539 (1995). ArticleCAS Google Scholar
Bean, A. J., Seifert, R., Chen, Y. A., Sacks, R. & Scheller, R. H. Hrs-2 is an ATPase implicated in Ca2+-regulated secretion. Nature385, 826–829 (1997). ArticleADSCAS Google Scholar
Sheng, M. PDZs and receptor/channel clustering: rounding up the latest suspects. Neuron17, 575–578 (1996). ArticleCAS Google Scholar
Dowling, J. E. The Retina. An Approachable Part of the Brain(Belknap, Cambridge, MA, (1987)). Google Scholar
Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning: A Laboratory Manual(Cold Spring Harbor Laboratory Press, New York, (1989)). Google Scholar
Hata, Y. & Südhof, T. C. Anovel ubiquitous form of munc18 interacts with multiple syntaxins. J. Biol. Chem.270, 13022–13028 (1991). Article Google Scholar
Guan, K. L. & Dixon, J. E. Eukaryotic proteins expressed in Escherischia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem.192, 262–267 (1991). ArticleCAS Google Scholar
Bucher, P., Karplus, K., Moeri, N. & Hofmann, K. Aflexible motif search technique based on generalized profiles. Comput. Chem.20, 3–23 (1996). ArticleCAS Google Scholar
Henikoff, S. & Henikoff, J. G. Amino acid substitution matrices from protein blocks. Proc. Natl Acad. USA89, 10915–10919 (1992). ArticleADSCAS Google Scholar
Hofmann, K. & Bucher, P. The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem. Sci.20, 347–349 (1995). ArticleCAS Google Scholar
Schmitz, F., Bechmann, M. & Drenckhahn, D. Purification of synaptic ribbons, structural components of the photoreceptor active zone complex. J. Neurosci.15, 7109–7116 (1996). Article Google Scholar
McMahon, H.et al. Cellubrevin: a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein. Nature364, 346–349 (1993). ArticleADSCAS Google Scholar
Ichtchenko, K.et al. Neuroligin 1: A splice-site specific ligand for β-neurexins. Cell81, 435–443 (1995). ArticleCAS Google Scholar
Matsui, Y.et al. Nucleotide and deduced amino acid sequences of a GTP-binding protein family with molecular weights of 25,000 from bovine brain. J. Biol. Chem.263, 11071–11074 (1988). CASPubMed Google Scholar