Killing activity of neutrophils is mediated through activation of proteases by K+ flux (original) (raw)
References
Metchnikoff, B. Immunity in Infective Diseases (Cambridge Univ. Press, 1905). Google Scholar
Sbarra, A. J. & Karnovsky, M. L. The biochemical basis of phagocytosis. 1. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes. J. Biol. Chem.234, 1355–1362 (1959). CASPubMed Google Scholar
Mandell, G. L. Bactericidal activity of aerobic and anaerobic polymorphonuclear neutrophils. Infect. Immun.9, 337–341 (1974). CASPubMedPubMed Central Google Scholar
Babior, B. M., Curnutte, J. T. & Kipnes, R. S. Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J. Lab. Clin. Med.85, 235–244 (1975). CASPubMed Google Scholar
Babior, B. M., Kipnes, R. S. & Curnutte, J. T. Biological defence mechanisms: the production by leukocytes of superoxide, a potential bactericidal agent. J. Clin. Invest.52, 741–744 (1973). ArticleCAS Google Scholar
Thrasher, A. J., Keep, N. H., Wientjes, F. & Segal, A. W. Chronic granulomatous disease. Biochim. Biophys. Acta1227, 1–24 (1994). ArticleCAS Google Scholar
Klebanoff, S. J. Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes. Semin. Hematol.12, 117–142 (1975). CASPubMed Google Scholar
Belaaouaj, A. et al. Mice lacking neutrophil elastase reveal impaired host defense against Gram-negative bacterial sepsis. Nature Med.4, 615–618 (1998). ArticleCAS Google Scholar
Tkalcevic, J. et al. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity12, 201–210 (2000). ArticleCAS Google Scholar
Hampton, M. B., Kettle, A. J. & Winterbourn, C. C. Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Staphylococcus aureus by neutrophils. Infect. Immun.64, 3512–3517 (1996). CASPubMedPubMed Central Google Scholar
Aratani, Y., Koyama, H., Nyui, S., Suzuki, K., Kura, F. & Maeda, N. Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect. Immun.67, 1828–1836 (1999). CASPubMedPubMed Central Google Scholar
Cross, A. R. & Jones, O. T. The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem. J.237, 111–116 (1986). ArticleCAS Google Scholar
Segal, A. W., Geisow, M., Garcia, R., Harper, A. & Miller, R. The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature290, 406–409 (1981). ArticleADSCAS Google Scholar
Segal, A. W. & Coade, S. B. Kinetics of oxygen consumption by phagocytosing human neutrophils. Biochem. Biophys. Res. Commun.84, 611–617 (1978). ArticleCAS Google Scholar
Hampton, M. B., Kettle, A. J. & Winterbourn, C. C. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood92, 3007–3017 (1998). CASPubMed Google Scholar
Bu-Ghanim, H. N., Segal, A. W., Keep, N. H. & Casimir, C. M. Molecular analysis in three cases of X91-variant chronic granulomatous disease. Blood86, 3575–3582 (1995). CASPubMed Google Scholar
Jiang, Q., Griffin, D. A., Barofsky, D. F. & Hurst, J. K. Intraphagosomal chlorination dynamics and yields determined using unique fluorescent bacterial mimics. Chem. Res. Toxicol.10, 1080–1089 (1997). ArticleCAS Google Scholar
Styrt, B. & Klempner, M. S. Internal pH of human neutrophil lysosomes. FEBS Lett.149, 113–116 (1982). ArticleCAS Google Scholar
Henderson, L. M., Chappell, J. B. & Jones, O. T. The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel. Biochem. J.246, 325–329 (1987). ArticleCAS Google Scholar
Nanda, A. & Grinstein, S. Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils. Proc. Natl Acad. Sci. USA88, 10816–10820 (1991). ArticleADSCAS Google Scholar
DeCoursey, T. E., Cherny, V. V., Zhou, W. & Thomas, L. L. Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils. Proc. Natl Acad. Sci. USA97, 6885–6889 (2000). ArticleADSCAS Google Scholar
Menegazzi, R., Busetto, S., Dri, P., Cramer, R. & Patriarca, P. Chloride ion efflux regulates adherence, spreading, and respiratory burst of neutrophils stimulated by tumor necrosis factor-α (TNF) on biologic surfaces. J. Cell Biol.135, 511–522 (1996). ArticleCAS Google Scholar
Clapp, L. H. & Tinker, A. Potassium channels in the vasculature. Curr. Opin. Nephrol. Hypertens.7, 91–98 (1998). CASPubMed Google Scholar
Love, W. D. & Burch, G. E. A comparison of potassium42, rubidium86, and cesium134 as traces of potassium in the study of cation metabolism of human erythrocytes in vitro. J. Lab. Clin. Med.41, 351–362 (1953). CASPubMed Google Scholar
Segal, A. W. & Meshulam, T. Production of superoxide by neutrophils: a reappraisal. FEBS Lett.100, 27–32 (1979). ArticleCAS Google Scholar
Ince, C. et al. Intracellular K+, Na+ and Cl- concentrations and membrane potential in human monocytes. Biochim. Biophys. Acta905, 195–204 (1987). ArticleCAS Google Scholar
Potma, E., de Boeij, W. P., van Haastert, P. J. & Wiersma, D. A. Real-time visualization hydrodynamics in single living cells. Proc. Natl Acad. Sci. USA98, 1577–1582 (2001). ArticleADSCAS Google Scholar
Aderem, A. & Underhill, D. M. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol.17, 593–623 (1999). ArticleCAS Google Scholar
Rizoli, S. B., Rotstein, O. D., Parodo, J., Phillips, M. J. & Kapus, A. Hypertonic inhibition of exocytosis in neutrophils: central role for osmotic actin skeleton remodeling. Am. J. Physiol. Cell Physiol.279, C619–C633 (2000). ArticleCAS Google Scholar
Kolset, S. O. & Gallagher, J. T. Proteoglycans in haemopoietic cells. Biochim. Biophys. Acta1032, 191–211 (1990). CASPubMed Google Scholar
Odeberg, H. & Olsson, I. Antibacterial activity of cationic proteins from human granulocytes. J. Clin. Invest.56, 1118–1124 (1975). ArticleCAS Google Scholar
Winterbourn, C. C., Garcia, R. C. & Segal, A. W. Production of the superoxide adduct of myeloperoxidase (compound III) by stimulated human neutrophils and its reactivity with hydrogen peroxide and chloride. Biochem. J.228, 583–592 (1985). ArticleCAS Google Scholar
Kettle, A. J. & Winterbourn, C. C. A kinetic analysis of the catalase activity of myeloperoxidase. Biochemistry40, 10204–10212 (2001). ArticleCAS Google Scholar
Guerin, I. & de Chastellier, C. Pathogenic mycobacteria disrupt the macrophage actin filament network. Infect. Immun.68, 2655–2662 (2000). ArticleCAS Google Scholar
Henderson, L. M. & Meech, R. W. Evidence that the product of the human X-linked CGD gene, gp91-phox, is a voltage-gated H+ pathway. J. Gen. Physiol.114, 771–786 (1999). ArticleCAS Google Scholar
Maturana, A. et al. Heme histidine ligands within gp91phox modulate proton conduction by the phagocyte NADPH oxidase. J. Biol. Chem.276, 30277–30284 (2001). ArticleCAS Google Scholar
Nanda, A., Romanek, R., Curnutte, J. T. & Grinstein, S. Assessment of the contribution of the cytochrome b moiety of the NADPH oxidase to the transmembrane H+ conductance of leukocytes. J. Biol. Chem.269, 27280–27285 (1994). CASPubMed Google Scholar
De Coursey, T. E., Cherny, V. V., Morgan, D., Katz, B. Z. & Dinauer, M. C. The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps. J. Biol. Chem.276, 36063–36066 (2001). ArticleCAS Google Scholar
McCord, J. M. & Wong, K. in Oxygen Free Radicals and Tissue Damage (ed. Fitzsimons, D. W.) 343–360 (Excerpta Medica, Amsterdam, 1979). Google Scholar
Klebanoff, S. J. & Pincus, S. H. Hydrogen peroxide utilization in myeloperoxidase-deficient leukocytes: a possible microbicidal control mechanism. J. Clin. Invest.50, 2226–2229 (1971). ArticleCAS Google Scholar
Brennan, M. L. et al. Increased atherosclerosis in myeloperoxidase-deficient mice. J. Clin. Invest.107, 419–430 (2001). ArticleCAS Google Scholar
Klebanoff, S. J. & Clark, R. A. Iodination by human polymorphonuclear leukocytes: a re-evaluation. J. Lab. Clin. Med.89, 675–686 (1977). CASPubMed Google Scholar
Grogan, A. et al. Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. J. Cell Sci.110, 3071–3081 (1997). CASPubMed Google Scholar
Hall, T. A. & Gupta, B. L. in Principles of Analytical Electron Microscopy (eds Joy, D. C., Romig, A. D. & Goldstein, J. I.) 219–248 (Plenum, London, 1986). Book Google Scholar
Olsen, R. L. & Little, C. Purification and some properties of myeloperoxidase and eosinophil peroxidase from human blood. Biochem. J.209, 781–787 (1983). ArticleCAS Google Scholar
Sadir, R., Baleux, F., Grosdidier, A., Imberty, A. & Lortat-Jacob, H. Characterization of the stromal cell-derived factor-1–α-heparin complex. J. Biol. Chem.276, 8288–8296 (2001). ArticleCAS Google Scholar
Vita, F. et al. Preparation of membrane fractions from human neutrophil granules: A simple method. Methods Cell Sci.19, 197–205 (1997). Article Google Scholar
Amos, B. J., Pocock, G. & Richards, C. D. On the role of bicarbonate as a hydrogen ion buffer in rat CNS neurones. Exp. Physiol.81, 623–632 (1996). ArticleCAS Google Scholar