Protein kinase Cδ controls self-antigen-induced B-cell tolerance (original) (raw)

• Goodnow, C. C. et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334, 676–682 (1988).
  Article ADS CAS Google Scholar
• Nemazee, D. A. & Burki, K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337, 562–566 (1989).
  Article ADS CAS Google Scholar
• Hartley, S. B. et al. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353, 765–769 (1991).
  Article ADS CAS Google Scholar
• Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607–614 (1992).
  Article ADS CAS Google Scholar
• Le Good, J. A. et al. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281, 2042–2045 (1998).
  Article ADS CAS Google Scholar
• Watanabe, T. et al. Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-δ subspecies. Proc. Natl Acad. Sci. USA 89, 10159–10163 (1992).
  Article ADS CAS Google Scholar
• Mischak, H. et al. Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J. Biol. Chem. 268, 6090–6096 (1993).
  CAS PubMed Google Scholar
• Emoto, Y. et al. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J. 14, 6148–6156 (1995).
  Article CAS Google Scholar
• Ghayur, T. et al. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J. Exp. Med. 184, 2399–2404 (1996).
  Article CAS Google Scholar
• Leitges, M. et al. Exacerbated vein graft arteriosclerosis in protein kinase Cδ-null mice. J. Clin. Invest. 108, 1505–1512 (2001).
  Article CAS Google Scholar
• Hippen, K. L., Tze, L. E. & Behrens, T. W. CD5 maintains tolerance in anergic B cells. J. Exp. Med. 191, 883–890 (2000).
  Article CAS Google Scholar
• Prodeus, A. P. et al. A critical role for complement in maintenance of self-tolerance. Immunity 9, 721–731 (1998).
  Article CAS Google Scholar
• Fulcher, D. A. et al. The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help. J. Exp. Med. 183, 2313–2328 (1996).
  Article CAS Google Scholar
• Healy, J. I. et al. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 6, 419–428 (1997).
  Article CAS Google Scholar
• Leitges, M. et al. Immunodeficiency in protein kinase C β-deficient mice. Science 273, 788–791 (1996).
  Article ADS CAS Google Scholar
• Kang, S. W. et al. PKCβ modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J. 20, 5692–5702 (2001).
  Article CAS Google Scholar
• Doerre, S. & Corley, R. B. Constitutive nuclear translocation of NF-κB in B cells in the absence of IκB degradation. J. Immunol. 163, 269–277 (1999).
  CAS PubMed Google Scholar
• Glynne, R. et al. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature 403, 672–676 (2000).
  Article ADS CAS Google Scholar
• Chan, V. W. et al. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J. Exp. Med. 188, 93–101 (1998).
  Article CAS Google Scholar
• Nolan, G. P., Fiering, S., Nicolas, J. F. & Herzenberg, L. A. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on β-d-galactosidase activity after transduction of Escherichia coli lacZ. Proc. Natl Acad. Sci. USA 85, 2603–2607 (1988).
  Article ADS CAS Google Scholar
• Metzger, D. W., Ch’ng, L. K., Miller, A. & Sercarz, E. E. The expressed lysozyme-specific B cell repertoire. I. Heterogeneity in the monoclonal anti-hen egg white lysozyme specificity repertoire, and its difference from the in situ repertoire. Eur. J. Immunol. 14, 87–93 (1984).
  Article CAS Google Scholar
• Smith-Gill, S. J. et al. Mapping the antigenic epitope for a monoclonal antibody against lysozyme. J. Immunol. 128, 314–322 (1982).
  CAS PubMed Google Scholar
• Miyake, K., Yamashita, Y., Hitoshi, Y., Takatsu, K. & Kimoto, M. Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: unresponsiveness of X-linked immunodeficient B cells. J. Exp. Med. 180, 1217–1224 (1994).
  Article CAS Google Scholar
• Yamashita, Y. et al. A monoclonal antibody against a murine CD38 homologue delivers a signal to B cells for prolongation of survival and protection against apoptosis in vitro: unresponsiveness of X-linked immunodeficient B cells. Immunology 85, 248–255 (1995).
  CAS PubMed PubMed Central Google Scholar
• Lipford, G. B. et al. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27, 2340–2344 (1997).
  Article CAS Google Scholar
• Kozono, Y. et al. Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. J. Immunol. 160, 1565–1572 (1998).
  CAS PubMed Google Scholar
• Lyons, A. B. & Parish, C. R. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171, 131–137 (1994).
  Article CAS Google Scholar