Opposite thermosensor in fruitfly and mouse (original) (raw)

Ion channels

Nature volume 423, pages 822–823 (2003)Cite this article

Abstract

Several members of the TRP (for transient receptor potential) family of ion channels act as physiological temperature sensors in mammals1,2,3,4,5,6, but it is not known whether the invertebrate TRP subfamilies that are found in the fruitfly Drosophila and the roundworm Caenorhabditis elegans can be directly activated by temperature. Here we show that the Drosophila orthologue of ANKTM1, which is a cold-activated ion channel in mammals, responds to a warming rather than a cooling stimulus. The thermosensing function of these channels is therefore evolutionarily conserved, and they show a surprising flexibility in their response to different temperature ranges.

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Figure 1: Drosophila orthologue of the mammalian ion channel ANKTM1 is activated by warm, not cold, temperatures.

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Authors and Affiliations

  1. Genomics Institute of the Novartis Research Foundation, San Diego, 92121, California, USA
    Veena Viswanath, Andrea M. Peier, Matt J. Petrus, Van M. Lee, Ardem Patapoutian & Tim Jegla
  2. Department of Cell Biology, The Scripps Research Institute, La Jolla, 92037, California, USA
    Gina M. Story, Sun Wook Hwang & Ardem Patapoutian

Authors

  1. Veena Viswanath
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  2. Gina M. Story
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  3. Andrea M. Peier
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  4. Matt J. Petrus
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  5. Van M. Lee
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  6. Sun Wook Hwang
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  7. Ardem Patapoutian
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  8. Tim Jegla
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Corresponding author

Correspondence toArdem Patapoutian.

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Competing interests

The authors declare no competing financial interests.

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Viswanath, V., Story, G., Peier, A. et al. Opposite thermosensor in fruitfly and mouse.Nature 423, 822–823 (2003). https://doi.org/10.1038/423822a

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