Ibuprofen-like activity in extra-virgin olive oil (original) (raw)

Phytochemistry

Nature volume 437, pages 45–46 (2005)Cite this article

Enzymes in an inflammation pathway are inhibited by oleocanthal, a component of olive oil.

Abstract

Newly pressed extra-virgin olive oil contains oleocanthal — a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen1. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.

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Figure 1: Structures of (−)oleocanthal (left) and the anti-inflammatory drug ibuprofen (right).

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References

  1. Breslin, P. A. S., Gingerich, T. N. & Green, B. G. Chem. Sens. 26, 55–66 (2001).
    Article CAS Google Scholar
  2. Andrewes, P., Busch, J. L. H. C., De Joode, T., Groenewegen, A. & Alexandre, H. J. Agric. Food Chem. 51, 1415–1420 (2003).
    Article CAS PubMed Google Scholar
  3. Fischer, R., Griffen, F., Archer, R. C., Zinsmeister, S. C. & Jastram, P. S. Nature 207, 1049–1053 (1965).
    Article ADS CAS PubMed Google Scholar
  4. Vane, J. R. & Botting, R. M. Inflamm. Res. 44, 1–10 (1995).
    Article CAS PubMed Google Scholar
  5. Harris, R. E., Beebe-Donk, J., Doss, H. & Burr Doss, D. Oncol. Rep. 13, 559–583 (2005).
    CAS PubMed Google Scholar
  6. Zhou, Y. et al. Science 302, 1215–1217 (2003).
    Article ADS CAS PubMed Google Scholar
  7. Hu, F. N. Engl. J. Med. 348, 2595–2596 (2003).
    Article PubMed Google Scholar
  8. Tuck, K., Freeman, M., Hayball, P., Stretch, G. & Stupans, I. J. Nutr. 131, 1993–1996 (2001).
    Article CAS PubMed Google Scholar
  9. Miro-Casas, E. et al. Clin. Chem. 49, 945–952 (2003).
    Article CAS PubMed Google Scholar
  10. Hennekens, C. H. Am. J. Man. Care 8 (suppl.), 691–700 (2002).
    Google Scholar
  11. Lefer, A. M., Muller, H. F. & Smith, J. B. Br. J. Pharmacol. 83, 125–130 (1984).
    Article CAS PubMed PubMed Central Google Scholar
  12. Togna, G. I., Togna, A. R., Franconi, M., Marra, C. & Guiso, M. J. Nutr. 133, 2532–2536 (2003).
    Article CAS PubMed Google Scholar
  13. Mitchell, J. A. et al. Proc. Natl Acad. Sci. USA 90, 11693–11697 (1993).
    Article ADS CAS PubMed PubMed Central Google Scholar

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Author notes

  1. Russell S. J. Keast
    Present address: Food Science, RMIT University, Melbourne, Victoria, 3001, Australia
  2. Chi-Ho Lee
    Present address: Animal Resources Research Center, Konkuk University, Gwangjin-Gu, Seoul, 143-130, South Korea

Authors and Affiliations

  1. Monell Chemical Senses Center, Philadelphia, 19104, Pennsylvania, USA
    Gary K. Beauchamp, Russell S. J. Keast, Chi-Ho Lee, Amos B. Smith & Paul A. S. Breslin
  2. Department of Pharmacology and Toxicology, University of the Sciences in Philadelphia, Philadelphia, 19104, Pennsylvania, USA
    Diane Morel
  3. Department of Chemistry, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA
    Qiang Han & Amos B. Smith
  4. Firmenich, PO Box 5880, Princeton, 08543, New Jersey, USA
    Jianming Lin & Jana Pika

Authors

  1. Gary K. Beauchamp
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  2. Russell S. J. Keast
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  3. Diane Morel
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  4. Jianming Lin
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  5. Jana Pika
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  6. Qiang Han
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  7. Chi-Ho Lee
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  8. Amos B. Smith
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  9. Paul A. S. Breslin
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Corresponding author

Correspondence toPaul A. S. Breslin.

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The authors declare no competing financial interests.

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Beauchamp, G., Keast, R., Morel, D. et al. Ibuprofen-like activity in extra-virgin olive oil.Nature 437, 45–46 (2005). https://doi.org/10.1038/437045a

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