Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds (original) (raw)
References
Johnson,R. L. & Tabin,C. J. Molecular models for vertebrate limb development. Cell90, 979–990 (1997). ArticleCAS Google Scholar
Laufer,E., Nelson,C. E., Johnson,R. L., Morgan,B. A. & Tabin,C. Sonic hedgehog and Fgf-4 act through a signalling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell79, 993–1003 (1994). ArticleCAS Google Scholar
Niswander,L., Jeffrey,S., Martin,G. R. & Tickle,C. A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature371, 609–612 (1994). ArticleADSCAS Google Scholar
Hsu,D., Economides,A., Wang,X., Eimon,P. & Harland,R. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonise BMP activities. Mol. Cell1, 673–83 (1998). ArticleCAS Google Scholar
Chan,D. C., Wynshaw-Boris,A. & Leder, P. Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud. Development121, 3151–3162 (1995). CASPubMed Google Scholar
Haramis,A. G., Brown,J. M. & Zeller,R. The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5′HoxD genes during limb pattern formation. Development121, 4237–4245 (1995). CASPubMed Google Scholar
Kuhlman,J. & Niswander,L. Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge. Development124, 133–139 (1997). CASPubMed Google Scholar
Chiang,C. et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature383, 407–413 (1996). ArticleADSCAS Google Scholar
St-Jacques,B. et al. Sonic hedgehog signaling is essential for hair development. Curr. Biol.8, 1058–1068 (1998). ArticleCAS Google Scholar
Woychik,R. P., Maas,R. L., Zeller,R., Vogt,T. F. & Leder,P. ‘Formins’: Proteins deduced from the alternative transcripts of the limb deformity gene. Nature346, 850–853 (1990). ArticleADSCAS Google Scholar
Mass,R. L., Zeller,R., Woychik,R. P., Vogt,T. F. & Leder,P. Disruption of formin-encoding transcripts in two mutant limb deformity alleles. Nature346, 853–855 (1990). ArticleADSCAS Google Scholar
Zuniga,A. & Zeller,R. Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development126, 13–21 (1999). CASPubMed Google Scholar
Duprez,D., Fournier-Thibault,C. & LeDouarin,N. Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb. Development125, 495–505 (1998). CASPubMed Google Scholar
Marigo,V., Johnson,R. L., Vortkamp,A. & Tabin,C. J. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol.180, 273–283 (1996). ArticleCAS Google Scholar
Marigo,V., Scott,M. P., Johnson,R. L., Goodrich,L. V. & Tabin,C. J. Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development122, 1225–1233 (1996). CASPubMed Google Scholar
Trumpp,A., Blundell,P. A., de la Pompa,J. L. & Zeller,R. The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis. Genes Dev.6, 14–28 (1992). ArticleCAS Google Scholar
Zeller,R., Jackson-Grusby,L. & Leder,P. The limb deformity gene is required for apical ectodermal ridge differentiation and anterio posterior limb pattern formation. Genes Dev.3, 1481–1492 (1989). ArticleCAS Google Scholar
Duprez,D. M., Kostakopoulou,K., Francis-West,P. H., Tickle,C. & Brickell,P. M. Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb. Development122, 1821–1828 (1996). CASPubMed Google Scholar
Cho,K. & Blitz,I. BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation. Curr. Opin. Genet. Dev.8, 443–449 (1998). ArticleCAS Google Scholar
Pizette,S. & Niswander,L. BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development126, 883–894 (1999). CASPubMed Google Scholar
McMahon,J. et al. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev.12, 1438–1452 (1998). ArticleCAS Google Scholar
Brunet,L., McMahon,J., McMahon,A. & Harland,R. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science280, 1455–1457 (1998). ArticleADSCAS Google Scholar
Lamb,T. et al. Neural induction by the secreted polypeptide noggin. Science262, 713–718 (1993). ArticleADSCAS Google Scholar
Francis,P. H., Richardson,M. K., Brickell, P M. & tickle,C. Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Development120, 209–218 (1994). CASPubMed Google Scholar
Hofmann,C., Luo,G., Balling,R. & Karsenty,G. Analysis of limb patterning in BMP-7-deficient mice. Dev. Genet.19, 43–50 (1996). ArticleCAS Google Scholar
Niswander,L. & Martin,G. R. FGF-4 and BMP-2 have opposite effects on limb growth. Nature361, 68–71 (1993). ArticleADSCAS Google Scholar
Fraidenraich,D., Lang,R. & Basilico,C. Distinct regulatory elements govern Fgf4 gene expression in the mouse blastocyst, myotome, and developing limb. Dev. Biol.204, 197–209 (1998). ArticleCAS Google Scholar
Nellen,D., Burke,R., Struhl,G. & Basler,K. Direct and long-range action of a DPP morphogen gradient. Cell85, 357–368 (1996). ArticleCAS Google Scholar
Lussier,M., Canoun,C., Ma,C., Sank,A. & Shuler,C. Interdigital soft tissue separation induced by retinoic acid in mouse limbs cultured in vitro. Int. J. Dev. Biol.37, 555–564 (1993). CASPubMed Google Scholar
Ingham,P. Transducing Hedgehog: the story so far. EMBO J.17, 3505–3511 (1998). ArticleCAS Google Scholar