Lipid A mutant Salmonella with suppressed virulence and TNFα induction retain tumor-targeting in vivo (original) (raw)

References

1. Pawelek, J., Low, K.B., and Bermudes, D. 1997. Tumor-targeted Salmonella as a novel anti-cancer vector. Cancer Res. 57: 4537–4544.
   Google Scholar
2. Bone, R.C. 1992. Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). J. Am. Med. Assoc. 268: 3452–3455.
   Article Google Scholar
3. Dinarello, C.A., Gelfand, J.A., and Wolff, S.M. 1993. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. J. Am. Med. Assoc. 269: 1829–1835.
   Article Google Scholar
4. Flad, H.-D., Loppnow, H., Rietschel, E.T., and Ulmer, A.J. 1993. Agonists and antagonists for lipopolysaccharide-induced cytokines. Immunobiology 187: 303– 316.
   Article Google Scholar
5. Kovach, N.L., Yee, E., Munford, R.S., Raetz, C.R.H., and Harlan, J.M. 1990. Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo. J. Exp. Med. 172: 77–84.
   Article Google Scholar
6. Rick, P.D. and Osborn, M.J. 1977. Lipid A mutants of Salmonella typhimurium: Characterization of a conditional lethal mutant in 3-deoxy-D-mannooctulosonate-8-phosphate synthetase. J. Biol. Chem. 252: 4895–4903.
   Google Scholar
7. Engel, H, Smink, A.J., van Wijngaarden, L., and Keck, W. 1992 Murine-metabolizing enzymes from Escherichia coli: Existence of a second lytic transglycosylase. J. Bacteriol. 174: 6394–6403.
   Article Google Scholar
8. Karow, M. and Georgopoulos, C. 1992 Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB. J. Bacteriol. 174: 702 –710.
   Article Google Scholar
9. Somerville, J.E., Cassaiano, L. Jr., Bainbridge, B., Cunningham, M.D., and Darveau, R.P. 1996. A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J. Clin. Invest. 97: 359–365.
   Article Google Scholar
10. Clementz, T., Zhou, Z., and Raetz, C.R.H. 1997. Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. J. Biol. Chem. 272: 10353–10360.
    Article Google Scholar
11. Khan, S.A., Everest, P., Servos, S., Foxwell, N., Zähringer, U., Brade, H. et al. 1998. A lethal role for lipid A in Salmonella infections. Mol. Microbiol. 29: 571– 579.
    Article Google Scholar
12. Carrier, M.J., Chatfield, S.N., Dougan, G., Nowicka, U.T.A., O'Callaghan, D., Beesley, J.E. et al. 1992. Expression of human IL-1β in Salmonella typhimurium. A model system for the delivery of recombinant therapeutic proteins in vivo. J. Immunol. 148: 1176–1181.
    Google Scholar
13. Eisenstein, T.K., Bushnell, B., Meissler, J.J. Jr., Dalal, N., Schafer, R., and Havas, H.F. 1995. Immunotherapy of a plasmacytoma with attenuated Salmonella. Med. Oncol. 12: 103–108.
    Article Google Scholar
14. Saltzman, D.A., Heise, C.P., Hasz, D.E., Zebede, M., Kelly, S.M., Curtiss, R. III et al. 1996. Attenuated Salmonella typhimurium containing interleukin-2 decreases MC-38 hepatic metastases: a novel anti-tumor agent. Cancer Biother. and Radiopharm. 11: 145– 153.
    Article Google Scholar
15. Saltzman, D.A., Katsanis, E., Heise, C.P., Hasz, D.E., Kelly, S.M., Curtiss, R. III et al. 1997. Patterns of hepatic and splenic colonization by an attenuated strain of Salmonella typhimurium containing the gene for human interleukin-2: a novel tumor agent. Cancer Biother. Radiopharm. 12: 37– 43.
    Article Google Scholar
16. Hoiseth, S.K.J. and Stocker, B.A.D. 1981. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291: 238–239.
    Article Google Scholar
17. Hohmann, E.L., Oletta, C.A., and Miller, S.I. 1996. Evaluation of a phoP/phoQ -deleted, _aroA_-deleted live oral Salmonella typhi vaccine strain in human volunteers. Vaccine 14: 19 –24.
    Article Google Scholar
18. Cardenas, L. and Clements, J.D. 1993. Stability, immunogenicity and expression of foreign antigens in bacterial vaccine vectors. Vaccine 11: 126–135.
    Article Google Scholar
19. Chabalgoity, J.A., Khan, C.M.A., Nash, A.A., and Hormaeche, C.E.A. 1996. Salmonella typhimurium htrA live vaccine expressing multiple copies of a peptide comprising amino acids 8-23 of herpes simplex virus glycoprotein D as a genetic fusion to tetanus toxin fragment C protects mice from herpes simplex virus infection. Mol. Microbiol. 19: 791–801.
    Article Google Scholar
20. Galan, J. and Curtiss, R III . 1989 . Virulence and vaccine potential of phoP mutants of S. typhimurium. Microbial Path. 6: 422 –433.
    Article Google Scholar
21. Gonzales, C., Hone, D., Noriega, F.R., Tacket, C.O., Davis, J.R., Losonsky, G. et al. 1994. Salmonella typhi vaccine strain CVD904 expressing the circumsporozoite protein of Plasmodium falciparum: strain construction and safety and immunogenicity in humans. J. Infect. Dis. 169: 927–931.
    Article Google Scholar
22. McSorley, S.J., Xu, D., and Liew, F.Y. 1997. Vaccine efficacy of Salmonella strains expressing glycoprotein 63 with different promoters. Infect. Immun. 65: 171–178.
    Google Scholar
23. Su, G-F., Brahmbhatt, H.N., deLorenzo, V., Wehland, J., and Timmis, K.N. 1992. Extracellular export of shiga toxin B-subunit/haemolysin A (C-terminus) fusion protein expressed in _Salmonella typhimurium aro_A-mutant and stimulation of B-subunit specific antibody responses in mice. Microbial. Pathogenesis 13: 465–476.
    Article Google Scholar
24. O'Callaghan, D., Maskell, D., Liew, F.Y., Easmon, C.S.F., and Dougan, G. 1988. Characterization of aromatic- and purine-dependent Salmonella typhimurium: Attenuation, persistence, and ability induce protective immunity in BALB/c mice. Infect. Immun. 56: 419–423.
    PubMed Central Google Scholar
25. Bone, R.C. 1993. Gram-negative sepsis: a dilemma of modern medicine. Clin. Microbiol. Rev. 6: 57– 68.
    Article Google Scholar
26. Ciacci-Woolwine, F., Blomfield, I.C., Richardson, S.H., and Mizel, S.B. 1998. Salmonella flagellin induces tumor necrosis factor alpha in a human promonocytic cell line. Infect. Immun. 66: 1127–1134.
    Google Scholar
27. Streilein, J.W. 1995. Unraveling immune privilege. Science 270: 1158–1159.
    Article Google Scholar
28. Russell, C.B., Thaler, D.S., and Dalhlquist, F.W. 1989. Chromosomal transformation of Escherichia coli recD – strains with linearized plasmids. J. Bacteriol. 171: 2609– 2613.
    Article Google Scholar
29. Davis, R.W., Botstein, D., and Roth, J.R. 1980. Advanced bacterial genetics . Cold Spring Harbor Laboratoy Press, Cold Spring Harbor, NY.
    Google Scholar
30. Galanos, C., Luderitz, O., and Westphal, O. 1969. A new method for the extraction of R lipopolysaccharides. Eur. J. Biochem. 9: 245–249.
    Article Google Scholar
31. Apicella, M.A., Griffiss, J.M., and Schneider, H. 1994. Isolation and characterization of lipopolysaccharides, lipoligosaccharides, and lipid A. Methods Enzymol. 235: 243–252.
    Google Scholar
32. Sklar, M.D., Tereba, A., Chen, B.D., and Walker, W.S. 1985 . Transformation of mouse bone marrow cells by transfection with a human oncogene related to c-myc is associated with the endogenous production of macrophage colony stimulating factor 1. J. Cell Physiol. 125: 403–412.
    Article Google Scholar
33. Elsinghorst, E.A. 1994. Measurement of invasion by gentamycin resistance. Methods Enzymol. 236: 405– 420.
    Article Google Scholar

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