From small flies come big discoveries about size control (original) (raw)

Nature Cell Biology volume 1, pages E191–E192 (1999)Cite this article

Abstract

Genetic analysis of an insulin signalling pathway in Drosophila hasuncovered a regulatory module that can control the size of cells, organs and the whole animal. This module appears to be unconnected with pattern formation, and may coordinate growth with nutrition.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: A pathway for growth control in flies.

References

  1. Bryant, P. J. & Simpson, P. Q. Rev. Biol. 59, 387–415 (1984).
    Article CAS Google Scholar
  2. Verdu, J., Buratovich, M. A., Wilder, E. L. & Birnbaum, M. J. Nature Cell Biol. 1, 500–506 (1999).
    Article CAS Google Scholar
  3. Neufeld, T. P., de la Cruz, A. F. A., Johnston, L. A. & Edgar, B. A. Cell 93, 1183–1193 (1999).
    Article Google Scholar
  4. Wienkove, D., Neufeld, T. P., Twardzik, T. Waterfield, M. D. & Leevers, S. J. Curr. Biol. 9, 1019–1029 (1999).
    Article Google Scholar
  5. Johnston, L. A., Prober, D.A., Edgar, B. A., Eisenman, R. N. & Gallant, P. Cell 98, 779–790 (1999).
    Article CAS Google Scholar
  6. Chen, C. Jack, J. & Garofalo, R. S. Endocrinol. 137, 846–856 (1996).
    Article CAS Google Scholar
  7. Bohni, R. et al. Cell 97, 865–875 (1999).
    Article CAS Google Scholar
  8. Montagne, J. et al. Science 285, 2126–2129 (1999).
    Article CAS Google Scholar
  9. Thomas, G. & Hall, M. N. Curr. Opin. Cell Biol. 9, 782–787 (1997).
    Article CAS Google Scholar
  10. Rameh, L. E. & Cantley, L. C. J. Biol. Chem. 274, 8347–8350 (1999).
    Article CAS Google Scholar
  11. Meyuhas, O., Avni, D. & Shama, S. in Translational Control (eds Hershey, J. W. B., Mathews, M. B. & Sonenberg, N.) 363–388 (Cold Spring Harb. Lab. Press, Cold Spring Harbor, 1996).
  12. Britton, J. S. & Edgar, B. A. Development 125, 2149–2158 (1998).
    CAS PubMed Google Scholar

Download references

Author information

Authors and Affiliations

  1. the Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, 98109-1024, Washington, USA
    Bruce A. Edgar

Authors

  1. Bruce A. Edgar
    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toBruce A. Edgar.

Rights and permissions

About this article

Cite this article

Edgar, B. From small flies come big discoveries about size control.Nat Cell Biol 1, E191–E192 (1999). https://doi.org/10.1038/70217

Download citation

This article is cited by