Oligonucleotide-based inhibition of embryonic gene expression (original) (raw)

• Christoffersen, R.E. Translating genomics information into therapeutics: a key role for oligonucleotides. Nat. Biotechnol. 15, 483– 484 (1997).
  Article CAS Google Scholar
• Juliano, R.L., Alahari, S., Yoo, H., Kole, R. & Cho, M. Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides. Pharm. Res. 16, 494–502 (1999).
  Article CAS Google Scholar
• Nyce, J.W. Insight into adenosine receptor function using antisense and gene-knockout approaches. Trends. Pharmacol. Sci. 20, 79–83 (1999).
  Article CAS Google Scholar
• Jones, D.A. & Fitzpatrick, F.A. Genomics and the discovery of new drug targets. Curr. Opin. Chem. Biol. 3, 71–76 (1999).
  Article CAS Google Scholar
• Bramlage, B., Luzi, E. & Eckstein, F. Designing ribozymes for the inhibition of gene expression. Trends. Biotechnol. 16, 434– 438 (1998).
  Article CAS Google Scholar
• Dickinson, L.A. et al. Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc. Natl. Acad. Sci. USA. 95, 12890–12895 (1998).
  Article CAS Google Scholar
• Mei, H.Y. et al. Discovery of selective, small-molecule inhibitors of RNA complexes—I. The Tat protein/TAR RNA complexes required for HIV-1 transcription. Bioorg. Med. Chem. 5, 1173–1184 (1997).
  Article CAS Google Scholar
• Tatton, W.G., Chalmers-Redman, R.M., Ju, W.Y., Wadia, J. & Tatton, N.A. Apoptosis in neurodegenerative disorders: potential for therapy by modifying gene transcription. J. Neural. Transm. Suppl. 49, 245– 268 (1997).
  CAS PubMed Google Scholar
• Wodarz, A. & Nusse, R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell Biol. 14, 59– 88 (1998).
  Article CAS Google Scholar
• Lai, L.W. & Lien, Y.H. Homologous recombination based gene therapy. Exp. Nephrol. 7, 11– 14 (1999).
  Article CAS Google Scholar
• Osterrieder, N. & Wolf, E. Lessons from gene knockouts. Rev. Sci. Tech. 17, 351– 364 (1998).
  Article CAS Google Scholar
• Sauer, B. Inducible gene targeting in mice using the Cre/lox system. Methods 14, 381–392 ( 1998).
  Article CAS Google Scholar
• Hynes, R.O. Targeted mutations in cell adhesion genes: what have we learned from them? Dev. Biol. 180, 402–412 (1996).
  Article CAS Google Scholar
• Hynes, R.O. & Bader, B.L. Targeted mutations in integrins and their ligands: their implications for vascular biology. Thromb. Haemostasis. 78, 83–87 ( 1997).
  Article CAS Google Scholar
• Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435– 439 (1996).
  Article CAS Google Scholar
• Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439– 442 (1996).
  Article CAS Google Scholar
• Robinson, G.S. et al. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc. Natl. Acad. Sci. USA. 93, 4851–4856 ( 1996).
  Article CAS Google Scholar
• Smyth, A.P., Rook, S.L., Detmar, M. & Robinson, G.S. Antisense oligonucleotides inhibit vascular endothelial growth factor/vascular permeability factor expression in normal human epidermal keratinocytes. J. Invest. Dermatol. 108, 523–526 (1997).
  Article CAS Google Scholar
• Chen, B. & Hales, B.F. Antisense oligonucleotide down-regulation of E-cadherin in the yolk sac and cranial neural tube malformations. Biol. Reprod. 53, 1229–1238 (1995).
  Article CAS Google Scholar
• Gaudette, M.F., Hampikian, G., Metelev, V., Agrawal, S. & Crain, W.R. Effect on embryos of injection of phosphorothioate-modified oligonucleotides into pregnant mice. Antisense. Res. Dev. 3, 391–397 (1993).
  Article CAS Google Scholar
• Bourque, A.J. & Cohen, A.S. Quantitative analysis of phosphorothioate oligonucleotides in biological fluids using direct injection fast anion-exchange chromatography and capillary gel electrophoresis. J. Chromatogr. Biomed. Appl. 662, 343–349 (1994).
  Article CAS Google Scholar
• Zhao, Q. et al. Cellular distribution of phosphorothioate oligonucleotide following intravenous administration in mice. Antisense. Nucleic. Acid. Drug Dev. 8, 451–458 (1998).
  Article CAS Google Scholar
• Pacifici, G.M. & Nottoli, R. Placental transfer of drugs administered to the mother. Clin. Pharmacokinet. 28, 235–269 (1995).
  Article CAS Google Scholar
• Yu, D. et al. Hybrid oligonucleotides: synthesis, biophysical properties, stability studies, and biological activity. Bioorg. Med. Chem. 4, 1685–1692 (1996).
  Article CAS Google Scholar
• Guvakova, M.A., Yakubov, L.A., Vlodavsky, I., Tonkinson, J.L. & Stein, C. A. Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. J. Biol. Chem. 270, 2620– 2627 (1995).
  Article CAS Google Scholar
• Rockwell, P. et al. Cell-surface perturbations of the epidermal growth factor and vascular endothelial growth factor receptors by phosphorothioate oligodeoxynucleotides. Proc. Natl. Acad. Sci. USA 94, 6523– 6528 (1997).
  Article CAS Google Scholar
• Takeichi, M. et al. Cadherins in brain patterning and neural network formation. Cold Spring Harb. Symp. Quant. Biol. 62, 505– 510 (1997).
  Article CAS Google Scholar
• Anderson, H. Adhesion molecules and animal development. Experientia 46, 2–13 (1990).
  Article CAS Google Scholar
• Senger, D.R. et al. Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev. 12, 303–324 (1993).
  Article CAS Google Scholar
• Ferrara, N. Vascular endothelial growth factor: molecular and biological aspects. Curr. Top. Microbiol. Immunol. 237, 1– 30 (1999).
  CAS PubMed Google Scholar
• Aiello, L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480–1487 ( 1994).
  Article CAS Google Scholar
• Baumgartner, I. & Isner, J.M. Stimulation of peripheral angiogenesis by vascular endothelial growth factor (VEGF). Vasa. 27, 201–206 ( 1998).
  CAS PubMed Google Scholar
• Grunstein, J., Roberts, W.G., Mathieu-Costello, O., Hanahan, D. & Johnson, R.S. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res. 59, 1592– 1598 (1999).
  CAS PubMed Google Scholar
• Kitamoto, Y., Tokunaga, H. & Tomita, K. Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis. J. Clin. Invest. 99, 2351–2357 (1997).
  Article CAS Google Scholar
• Chirgwin, J.M., Przybyla, A.E., MacDonald, R.J. & Rutter, W.J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294– 5299 (1979).
  Article CAS Google Scholar