Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke (original) (raw)

• Klatzo, I. Neuropathological aspects of brain edema. Acta Neurochir.Suppl. 60, 3–6 (1994).
  CAS Google Scholar
• Fishman, R. Brain edema. N. Eng. J. Med. 293, 706–711 (1975).
  Article CAS Google Scholar
• Weed, L.H. & McKibben, P.S. Experimental alteration of brain bulk. Am. J. Physiol. 48, 531–558 (1919).
  Article Google Scholar
• Verkman, A.S. et al. Water transport across mammalian cell membranes. Am. J. Physiol. 48, C12–C30 (1996).
  Article Google Scholar
• King, L.S. & Agre, P. Pathophysiology of the aquaporin water channels. Ann. Rev. Physiol. 58, 619–648 (1996).
  Article CAS Google Scholar
• Nielsen, S., Smith, B.L., Christensen, E.I. & Agre, P. Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc. Natl. Acad. Sci. USA 90, 7275–7279 (1993).
  Article CAS Google Scholar
• Hasegawa, H., Zhang, R., Dohrman, A. & Verkman, A.S. Tissue-specific expression of mRNA encoding the rat kidney water channel CHIP28k by in situ hybridization. Am. J. Physiol. 264, C237–C245 (1993).
  Article CAS Google Scholar
• Frigeri, A., Gropper, M., Turck, C.W. & Verkman, A.S. Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc. Natl. Acad. Sci. USA 92, 4328–4331 (1995).
  Article CAS Google Scholar
• Nielsen, S. et al. Specialized membrane domains for water transport in glial cells: high- resolution immunogold cytochemistry of aquaporin-4 in rat brain. J. Neuro. 17, 171–180 (1997).
  Article CAS Google Scholar
• Ma, T. et al. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J. Clin. Invest. 100, 957–962 (1997).
  Article CAS Google Scholar
• Trachtman, H. Cell volume regulation: a review of cerebral adaptive mechanisms and implications for clinical treatment of osmolal disturbances. Ped. Nephrol. 1992, 104–112 (1992).
  Article Google Scholar
• Hossman, K.A. Experimental models for the investigation of brain ischemia. Cardiovasc. Res. 39, 106–120 (1998).
  Article Google Scholar
• Kondo, T. et al. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J. Neurosci. 17, 4180–4189 (1997).
  Article CAS Google Scholar
• Gullans, S.R. & Verbalis, J.G. Control of brain volume during hypoosmolar and hypoosmolar conditions. Annu. Rev, Med. 44, 289–301 (1993).
  Article CAS Google Scholar
• Wasterlain, C.G. & Torack, R.M. Cerebral edema in water intoxication. II. An ultrastructural study. Arch. Neurol. 19, 79–87 (1968).
  Article CAS Google Scholar
• Marmarou, A., Poll, W., Shulman, K. & Bhagavan, H. A simple gravimetric technique for measurement of cerebral edema. J. Neurosurg. 49, 530–537 (1978).
  Article CAS Google Scholar
• Nelson, S.R., Mantz, M.L. & Maxwell, J.A. Use of specific gravity in the measurement of cerebral edema. J. Appl. Physiol. 30, 268–271 (1971).
  Article CAS Google Scholar
• Hasegawa, H., Ma, T., Skach, W., Matthay, M. & Verkman, A.S. Molecular cloning of a mercurial-insensitive water channel expressed in selected water transporting tissues. J. Biol. Chem. 269, 5497–5500 (1994).
  CAS Google Scholar
• Jung, J.S. et al. Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proc. Natl. Acad. Sci. USA 91, 13052–13056 (1994).
  Article CAS Google Scholar
• Kimelberg, H. K. Current concepts of brain edema. Review of laboratory investigations. J. Neuro. 83, 1051–1059 (1995).
  CAS Google Scholar
• Bullock, R., Maxwell, W.L. & Graham, D.I. Glial swelling following cerebral contusion: an ultrstructural study. J. Neurol. Neurosurg. Psychiatry 54, 427–434 (1991).
  Article CAS Google Scholar
• Wasterlain, C.G. & Posner, J.B. Cerebral edema in water intoxication. I. Clinical and chemical observations. Arch. Neurol. 19, 71–78 (1968).
  Article CAS Google Scholar
• Landis, D.M. & Reese, T.S. Arrays of particles in freeze-fractures of astrocytic membranes. J. Cell. Biol. 60, 316–320 (1974).
  Article CAS Google Scholar
• Frigeri, A. et al. Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues. J. Cell. Sci. 108, 2993–3002 (1995).
  CAS Google Scholar
• Yang, B., Brown, D. & Verkman, A.S. The mercurial-insensitive water channel (AQP-4) form orthogonal arrays in stably transfected CHO cells. J. Biol. Chem. 271, 4577–4580 (1996).
  Article CAS Google Scholar
• Verbavatz, J.M., Ma, T., Gobin, R. & Verkman, A.S. Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4. J. Cell Sci. 110, 2855–2860 (1997).
  CAS Google Scholar
• Rash, J.E., Yasumura, T., Hudson, C.S., Agre, P. & Nielsen, S. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membrane in rat brain and spinal cord. Proc. Natl. Acad. Sci. USA 95, 11981–11986 (1998).
  Article CAS Google Scholar
• Nagelhus, E.A. et al. Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by acoenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia 26, 47–54 (1999).
  Article CAS Google Scholar
• Suzuki, M. et al. Disintegration of orthogonal arrays in perivascular astrocytic foot processes as an early event in acute global ischemia. Brain Res. 300, 141–145 (1984).
  Article CAS Google Scholar
• Hatton, J.D. & Ellisman, M.H. Orthogonal arrays are redistributed in the membranes of astroglia from alumina-induced epileptic foci. Epilepsia 25, 145–151 (1984).
  Article CAS Google Scholar
• Carrillo, P. et al. Prolonged severe hemorrhagic shock and resuscitation in rats does not cause subtle brain damage. J. Trauma 45, 239–248; discussion 248–239 (1998).
  Article CAS Google Scholar
• Fujimura, M. et al. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J. Neurosci. 19, 3414–3422 (1999).
  Article CAS Google Scholar
• Yang, G. et al. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25, 165–170 (1994).
  Article Google Scholar
• Swanson, R. A. et al. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow. Metab. 10, 290–293 (1990).
  Article CAS Google Scholar