Basal cell carcinomas in mice overexpressing Gli2 in skin (original) (raw)
- Brief Communication
- Published: March 2000
- Rong Mo2,3,
- Sandy Yu2,3,
- Xiaoyun Zhang2,3,
- Hiroshi Sasaki4,
- Chi-chung Hui2,3 &
- …
- Andrzej A. Dlugosz1
Nature Genetics volume 24, pages 216–217 (2000)Cite this article
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Abstract
Approximately 1,000,000 epithelial skin cancers are diagnosed in the United States each year and most are basal cell carcinomas (BCCs). The pathogenesis of these tumours involves constitutive activation of the Sonic hedgehog (Shh) signalling pathway (for review, see ref. 1). In many BCCs this can be attributed to loss-of-function mutations of PTCH (refs 2,3), which encodes a SHH receptor and antagonist. The specific downstream effector in the Shh pathway leading to cancer development is unknown. Here we show that transgenic mice overexpressing the transcription factor Gli2 in cutaneous keratinocytes develop multiple BCCs. These results establish Gli2 as a potent oncogene in skin and suggest a pivotal role for this transcription factor in the development of human BCC.
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References
- Booth, D.R. Cancer Metast. Rev. 18, 261–284 (1999).
Article CAS Google Scholar - Hahn, H. et al. Cell 85, 841–851 (1996).
Article CAS Google Scholar - Johnson, R.L. et al. Science 272, 1668–1671 (1996).
Article CAS Google Scholar - Matise, M.P. & Joyner, A.L. Oncogene 18, 7852–7859 (1999).
Article CAS Google Scholar - Dahmane, N., Lee, J., Robins, P., Heller, P. & Ruiz i Altaba, A. Nature 389, 876–881 (1997).
Article CAS Google Scholar - Hynes, M. et al. Neuron 19, 15–26 (1997).
Article CAS Google Scholar - Lee, J., Platt, K.A., Censullo, P. & Ruiz i Altaba, A. Development 124, 2537–2552 (1997).
CAS PubMed Google Scholar - Motoyama, J. et al. Nature Genet. 20, 54–57 (1998).
Article CAS Google Scholar - Ding, Q. et al. Development 125, 2533–2543 (1998).
CAS PubMed Google Scholar - Ramirez, A., Bravo, A., Jorcano, J.L. & Vidal, M. Differentiation 58, 53–64 (1994).
CAS PubMed Google Scholar - Markey, A.C., Lane, E.B., MacDonald, D.M. & Leigh, I.M. Br. J. Dermatol. 126, 154–160 (1992).
Article CAS Google Scholar - Smoller, B.R., van de Rijn, M., Lebrun, D. & Warnke, R.A. Br. J. Dermatol. 131, 28–31 (1994).
Article CAS Google Scholar - Oro, A.E. et al. Science 276, 817–821 (1997).
Article CAS Google Scholar - Xie, J. et al. Nature 391, 90–92 (1998).
Article CAS Google Scholar - Aszterbaum, M. et al. Nature Med. 5, 1285–1291 (1999).
Article CAS Google Scholar - Chiang, C. et al. Dev. Biol. 205, 1–9 (1999).
Article CAS Google Scholar
Acknowledgements
We thank S. Yuspa, P. Coulombe, D. Bol and J. Jorcano for reagents; L. Lowe, L. Su and T. Johnson for advice on tumour histology; L. Wei and M. Berard for preparing the transgenic mice; and E. Fearon, G. Cotsarelis, S. Egan, S. Morrison and J.T. Elder for constructive comments on the manuscript. C.-c.H. was partially supported by the National Cancer Institute of Canada. A.A.D was supported in part by the University of Michigan Comprehensive Cancer Center (NIH CA46592) and Center for Organogenesis.
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Authors and Affiliations
- University of Michigan Comprehensive Cancer Center and Department of Dermatology, Ann Arbor, Michigan, USA
Marina Grachtchouk & Andrzej A. Dlugosz - Program in Developmental Biology, The Hospital for Sick Children, University of Toronto,
Rong Mo, Sandy Yu, Xiaoyun Zhang & Chi-chung Hui - Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada
Rong Mo, Sandy Yu, Xiaoyun Zhang & Chi-chung Hui - Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Osaka, Japan
Hiroshi Sasaki
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Correspondence toChi-chung Hui or Andrzej A. Dlugosz.
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Grachtchouk, M., Mo, R., Yu, S. et al. Basal cell carcinomas in mice overexpressing Gli2 in skin.Nat Genet 24, 216–217 (2000). https://doi.org/10.1038/73417
- Issue Date: March 2000
- DOI: https://doi.org/10.1038/73417