Injecting new ideas into microarray printing (original) (raw)

Nature Biotechnology volume 18, pages 384–385 (2000)Cite this article

Microarray technology is changing the way biologists think about genetic networks and interactions between genes. Although the reductionist approach is crucial as a starting point in understanding the potential function of a given gene, it is clear that the ultimate result of a gene product is not a summation of a simple linear pathway, but the net interaction of multiple gene products and pathways. This holistic approach requires high-throughput analysis tools. To be truly useful, the system used to produce microarrays needs to address issues such as sensitivity, reproducibility, specificity, density, and cost.

In this issue, Yamomoto and colleagues1 describe a method for the generation of microarrays using the Bubble Jet variation of ink-jet technology developed by Canon (Tokyo). Their noncontact method may be more reliable than current contact printing approaches and also has the potential to substantially increase the density of probes deposited on the microarray surface.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: Spot the difference.

© Bob Crimi

References

  1. Okamoto, T., Suzuki, T. & Yamamoto, N. Nat. Biotechnol. 18, 438– 441 (2000)
    Article CAS Google Scholar
  2. http://abrf.org/ABRF/ResearchCommittees/DSRG/DSRG2000/
  3. Singh-Gasson, S. et al. Nat. Biotechnol. 17, 974– 978 (1999).
    Article CAS Google Scholar
  4. Phimister, B. (ed.) Nat. Genet. 21(1 Suppl) (1999 ).

Download references

Author information

Authors and Affiliations

  1. Thomas M. Harris is research associate, Aldo Massimi is associate, and Geoffrey Childs is professor at the department of molecular genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, 10461, NY
    Thomas M. Harris, Aldo Massimi & Geoffrey Childs

Authors

  1. Thomas M. Harris
    You can also search for this author inPubMed Google Scholar
  2. Aldo Massimi
    You can also search for this author inPubMed Google Scholar
  3. Geoffrey Childs
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Harris, T., Massimi, A. & Childs, G. Injecting new ideas into microarray printing.Nat Biotechnol 18, 384–385 (2000). https://doi.org/10.1038/74435

Download citation

This article is cited by

Associated content