De-mystifying the mechanism(s) of maspin (original) (raw)

References

1. Zou, Z. et al. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science 263, 526–529 (1994).
   Article CAS Google Scholar
2. Sager, R., Sheng, S., Pemberton, P.A. & Hendrix, M.J.C. in Current Topics in Microbiology and Immunology 213 (eds. Buntert and W. Birchmeier) 51–64 (Springer-Verlag, Berlin, 1996).
   Google Scholar
3. Zhou, Z. et al. P53 regulates the expression of the tumor suppressor gene. J. Biol. Chem. 275, 6051–6054 (2000).
   Article Google Scholar
4. Sheng, S., Pemberton, P.A. & Sager, R. Production, purification, and characterization of recombinant maspin proteins. J. Biol. Chem. 269, 30988–30993 (1994).
   CAS PubMed Google Scholar
5. Sager, R. Function of maspin. Science 265, 1893 (1994).
   Article Google Scholar
6. Pemberton, P.A. et al. The tumor suppressor maspin does not undergo the stress to relaxed transition or inhibit trypsin-like serine proteases. J. Biol. Chem. 270, 15832–15837 (1995).
   Article CAS Google Scholar
7. Fitzpatrick, P.A., Wong, D.T., Barr, P.J. & Pemberton, P.A. Functional implications of the modeled structure of maspin. Protein Eng. 9, 585–589 (1996).
   Article CAS Google Scholar
8. Pemberton, P.A. et al. Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface. J. Histochem. Cytochem. 45, 1697–1706 (1997).
   Article CAS Google Scholar
9. Sheng, S. et al. Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin. Proc. Natl. Acad. Sci. USA 95, 499–504 (1998).
   Article CAS Google Scholar
10. Liu T., Pemberton, P.A. & Robertson, A.D. Three-state unfolding and self-association of maspin, a tumor-suppressing serpin. J. Biol. Chem. 274,29628–29632 (1999).
    Article CAS Google Scholar
11. Sheng, S. et al. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells. Proc. Natl. Acad. Sci. USA 93, 11669–11674 (1996).
    Article CAS Google Scholar
12. Sternlicht, M.D. et al. Characterizations of the extracellular matrix and proteinase inhibitor content of human myoepithelial tumors. Laboratory Invest. 74, 781–796 (1996).
    CAS Google Scholar
13. Sternlicht, M.D. et al. The human myoepithelial cell is a natural tumor suppressor. Clinical Cancer Res. 3, 1949–1958 (1997).
    CAS Google Scholar
14. Seftor, R.E.B. et al. Maspin suppresses the invasive phenotype of human breast carcinoma. Cancer Res. 58, 5681–5685 (1998).
    CAS PubMed Google Scholar
15. Zhang, M., Volpert, O., Shi, Y.H. & Bouck N. Maspin is an angiogenesis inhibitor. Nature Med. 6,196–199 (2000).
    Article Google Scholar
16. Zhang, M., David, M. & Sager, R. Expression of maspin in prostate cells is regulated by a positive Ets element and a negative hormonal responsive element site recognized by androgen receptor. Proc. Natl. Acad. Sci. USA 94, 5673–5678 (1997).
    Article CAS Google Scholar
17. Domann, F.E., Rice, J.C., Hendrix, M.J.C. & Futscher, B.W. Epigenetic silencing of maspin gene expression in human breast cancers. Int. J. Cancer 85, 805, 810 (2000).
    Article CAS Google Scholar
18. Li, J.-J., Colburn, N.H. & Oberley, L.W. Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cells. Carcinogenesis 19,833–839 (1998).
    Article CAS Google Scholar
19. Mashimo, T. et al. The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by P53. Proc. Natl. Acad. Sci. USA 95, 11307–11311 (1998).
    Article CAS Google Scholar
20. Effert, P.J., Neubauer, A., Walther, P.J. & Liu, E.T. Alterations of the P53 gene are associated with the progression of a human prostate carcinoma. J. Urol. 147, 789–793 (1992).
    Article CAS Google Scholar

Download references