Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia (original) (raw)

References

  1. Sander, M. & German, M.S. The β-cell transcription factors and development of the pancreas. J. Mol. Med. 75, 327–340 (1997).
    Article CAS PubMed Google Scholar
  2. Edlund, T., Walker, M.D., Barr, P.J. & Rutter, W.J. Cell specific expression of the rat insulin gene. Science 230, 912–916 (1985).
    Article CAS PubMed Google Scholar
  3. Stoffers, D.A., Thomas, M.K. & Habener, J.F. The homeodomain protein IDX-1. Trends Endocrinol. & Metab. 8, 145–151 (1997).
    Article CAS Google Scholar
  4. Watada, H. et al. The human glucokinase gene β-cell-type promoter. An essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells . Diabetes 45, 1478–1488 (1996).
    Article CAS PubMed Google Scholar
  5. Miller, C.P., McGehee, R. & Habener, J.F. A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum stimulates somatostatin gene expression in pancreatic islets. EMBO J. 13, 1145– 1156 (1994).
    Article CAS PubMed PubMed Central Google Scholar
  6. Waeber, G., Thompson, N., Nicod, P. & Bonny, C. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol. Endocrinol. 10, 1327–1333 (1996).
    CAS PubMed Google Scholar
  7. Marshak, S., Totary, H., Cerasi, E. & Melloul, D. Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc. Natl. Acad. Sci. USA 93, 15057–15062 (1996).
    Article CAS PubMed PubMed Central Google Scholar
  8. Jonsson, J., Carlsson, L., Edlund, T. & Edlund, H. Insulin-promoter-factor-1 is required for pancreas development in mice. Nature 371, 606–609 (1994).
    Article CAS PubMed Google Scholar
  9. Offield, M.F. et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122, 983–995 (1996).
    CAS PubMed Google Scholar
  10. Edlund, H. Transcribing a pancreas. Diabetes 47, 1817 –1823 (1998).
    Article CAS PubMed Google Scholar
  11. Stoffers, D.A., Zinkin, N.T., Stanojevic, V., Clarke, W.L. & Habener, J.F. Pancreas agenesis attributable to a single nucleotide deletion in the human IPF-1 gene coding sequence. Nature Genet. 15, 106–110 (1997).
    Article CAS PubMed Google Scholar
  12. Seijffers, R. et al. Increase in PDX-1 levels supresses insulin gene expression in RIN-38 cells. Endocrinology 140, 3311 –3317 (1999).
    Article CAS PubMed Google Scholar
  13. Steiner, D.F., Chan, S.J., Welsh, M.J. & Kwok, S.C.M. Structure and evolution of the insulin gene. Annu. Rev. Genet. 19 , 463–484 (1985).
    Article CAS PubMed Google Scholar
  14. Siegfried, Z. & Cedar, H. DNA methylation: a molecular lock . Curr. Biol. 7, R305–R307 (1998).
    Article Google Scholar
  15. Van-Holde, K.E. Chromatin structure and regulation of gene expression. J. Biol. Chem. 272, 26073 (1997).
    Article CAS Google Scholar
  16. Vollenweider, F., Irminger, J.C., Gross, D.J., Villa-Komaroff, L. & Halban, P.A. Processing of proinsulin by transfected hepatoma (FAO) cells. J. Biol. Chem. 267, 14629–14636 (1992).
    CAS PubMed Google Scholar
  17. Steiner, D.F., Smeekens, S.P., Ohagi, S. & Chan, S.J. The new enzymology of precursor processing endopeptidases. J. Biol. Chem. 267, 23435–23438 ( 1992).
    CAS PubMed Google Scholar
  18. O'Doherty, R.M., Lehman, D.L., Telemaque-Potts, S. & Newgard, C.B. Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. Diabetes 48, 2022–2027 ( 1999).
    Article CAS PubMed Google Scholar
  19. Emens, L.A., Landers, D.W. & Moss, L.G. Hepatocyte nuclear factor 1 α is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. Proc. Natl. Acad. Sci. USA 89, 7300– 7304 (1992).
    Article CAS PubMed PubMed Central Google Scholar
  20. Lekstrom-Himes, J. & Xanthopoulos, K.G. Biological role of the CCAAT/enhancer-binding protein family of transcription factors . J.Biol. Chem. 273, 28545– 28548 (1998).
    Article CAS PubMed Google Scholar
  21. Weintraub, H., et al. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc. Natl. Acad. Sci. USA 86, 5434– 5438 (1989).
    Article CAS PubMed PubMed Central Google Scholar
  22. Heller, R.S., Stoffer, D.A., Hussain, M.A., Miller, C.P. & Habener, J.F. Misexpression of IDX-1 by Hoxa-4 promoter associated with agenesis of the cecum. Gastroenterology 115, 381–3871 ( 1998).
    Article CAS PubMed Google Scholar
  23. Alison, M. Liver stem cells: a two compartment system. Curr. Opin. Cell Biol. 10, 710–716 ( 1998).
    Article CAS PubMed Google Scholar
  24. Thorgeirsson, S.S. Hepatic stem cells in liver regeneration. FASEB J. 10, 1249–1256 (1996).
    Article CAS PubMed Google Scholar
  25. Gross, D.J., Leibowitz, G., Cerasi, E. & Kaiser, N. Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure. Endocrinology 137, 5610–5615 ( 1996).
    Article CAS PubMed Google Scholar

Download references