Plzf regulates limb and axial skeletal patterning (original) (raw)

References

  1. Pearse, R.V. & Tabin, C.J. The molecular ZPA. J. Exp. Zoology 282, 677–690 (1998).
    Article CAS Google Scholar
  2. Krumlauf, R. Hox genes in vertebrate development. Cell 78, 191–201 (1994).
    Article CAS PubMed Google Scholar
  3. Chen, Z. et al. Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J. 12, 1161–1167 (1995).
    Article Google Scholar
  4. Li, J.Y. et al. Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein. J. Biol. Chem. 272, 22447–22455 (1997).
    Article CAS PubMed Google Scholar
  5. Reid, A. et al. Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors. Blood 86, 4544–4552 (1995).
    CAS PubMed Google Scholar
  6. Chang, C.C., Ye, B.H., Chaganti, R.S. & Dalla-Favera, R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl Acad. Sci. USA 93, 6947–6952 (1996).
    Article CAS PubMed PubMed Central Google Scholar
  7. Hong, S.H., David, G., Wong, C.W., Dejean, A. & Privalsky, M.L. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor-α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia. Proc. Natl Acad. Sci. USA 94, 9028–9033 (1997).
    Article CAS PubMed PubMed Central Google Scholar
  8. He, L.-Z. et al. Distinct interactions of PML-RARα and PLZF-RARα with transcriptional co-repressors determine differential responses to retinoic acid in APL. Nature Genet. 18, 126–135 (1998).
    Article CAS PubMed Google Scholar
  9. Tickle, C. The number of polarizing region cells required to specify additional digits in the developing chick wing. Nature 289, 295–298 (1981).
    Article CAS PubMed Google Scholar
  10. Riddle, R.D., Johnson, E.L. & Tabin, C. Sonic Hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401–1416 (1993).
    Article CAS PubMed Google Scholar
  11. Morgan, B.A., Izpisua-Belmonte, J.C., Duboule, D. & Tabin, C.J. Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature 358, 236–239 (1992).
    Article CAS PubMed Google Scholar
  12. Goff, D.J. & Tabin, C.J. Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 124, 627–636 (1997).
    CAS PubMed Google Scholar
  13. Knezevic, V. et al. Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop. Development 124, 4523–4536 (1997).
    CAS PubMed Google Scholar
  14. Small, K.M. & Potter, S.S. Homeotic transformations and limb defects in HoxA11 mutant mice. Genes Dev. 7, 2318–2328 (1993).
    Article CAS PubMed Google Scholar
  15. Yokouchi, Y. et al. Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9, 2509–2522 (1995).
    Article CAS PubMed Google Scholar
  16. Fromental-Ramin, C. et al. Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. Development 122, 2997–3011 (1996).
    Google Scholar
  17. Davis, A.P., Witte, D.P., Hsieh-Li, H.M., Potter, S.S. & Capecchi, M.R. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375, 791–795 (1995).
    Article CAS PubMed Google Scholar
  18. Zou, H. & Niswander, L. Requirement for BMP signaling in interdigital apoptosis and scale formation. Science 272, 738–741 (1996).
    Article CAS PubMed Google Scholar
  19. Pollack, R.A., Jay, G. & Bieberich, C.J. Altering the boundaries of Hox3.1 expression: evidence for antipodal gene expression. Cell 71, 911–923 (1992).
    Article Google Scholar
  20. Jegalian, B.G. & Robertis, E.M. Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene. Cell 71, 901–910 (1992).
    Article CAS PubMed Google Scholar
  21. Avantaggiato, V. et al. Developmental analysis of murine promyelocyte leukemia zinc finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization. J. Neurosci. 15, 4927–4942 (1995).
    Article CAS PubMed PubMed Central Google Scholar
  22. Luo, G. et al. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 9, 2808–2820 (1995).
    Article CAS PubMed Google Scholar
  23. Dudley, A.T., Lyons, K.M. & Robertson, E.J.A. Requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9, 2795–2807 (1995).
    Article CAS PubMed Google Scholar
  24. Hoatlin, M.E. et al. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood 94, 3737–3747 (1999).
    CAS PubMed Google Scholar
  25. Davis, J.M. et al. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. Oncogene 18, 365–375 (1999).
    Article Google Scholar
  26. He, L.Z., Merghoub, T. & Pandolfi, P.P. In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications. Oncogene 18, 5278–5292 (1999).
    Article CAS PubMed Google Scholar
  27. Bhatia, M. et al. Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells. J. Exp. Med. 189, 1139–1148 (1999).
    Article CAS PubMed PubMed Central Google Scholar
  28. Van Oostveen, J., Bijl, J., Raaphorst, F., Walboomers, J. & Meijer, C. The role of homeobox genes in normal hematopoiesis and hematological malignancies. Leukemia 13, 1675–1690 (1999).
    Article CAS PubMed Google Scholar
  29. Tybulewicz, V.L., Crawford, C.E., Jackson, P.K., Bronson, R.T. & Mulligan, R.C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153–1163 (1991).
    Article CAS PubMed Google Scholar
  30. Ruthardt, M. et al. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor α (RAR α) and PLZF-RAR α fusion proteins on retinoic acid signalling. Mol. Cell. Biol. 17, 4859–4869 (1997).
    Article CAS PubMed PubMed Central Google Scholar
  31. Kessel, M. & Gruss, P. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes by retinoic acid. Cell 67, 89–104 (1991).
    Article CAS PubMed Google Scholar
  32. Wilkinson, D.G. Whole-mount in situ hybridization of vertebrate embryo. in In Situ hybridization: A Practical Approach (ed. Wilkinson, D.G.) 75–83 (IRL, Oxford, 1992).
    Google Scholar

Download references