A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses (original) (raw)

• Hughes, M. K. & Hughes, A. L. Natural selection on Plasmodium surface proteins. Mol. Biochem. Parasitol. 71, 99–113 (1995).
  Article CAS Google Scholar
• Conway, D.J. Natural selection on polymorphic malaria antigens and the search for a vaccine. Parasitol. Today 13, 26–29 (1997).
  Article CAS Google Scholar
• Escalante, A.A., Lal, A.A. & Ayala, F.J. Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum. Genetics 149, 189–202 (1998).
  CAS PubMed PubMed Central Google Scholar
• Berry, A. & Kreitman, M. Molecular analysis of an allozyme cline: Alcohol dehydrogenase in Drosophila melanogaster on the east coast of North America. Genetics 134, 869–893 (1993).
  CAS PubMed PubMed Central Google Scholar
• Taylor, M.F.J., Shen, Y. & Kreitman, M.E. A population genetic test of selection at the molecular level. Science 270, 1497–1499 (1995).
  Article CAS Google Scholar
• McDonald, J.H. in Non-Neutral Evolution: Theories and Molecular Data. (ed. Golding, B.) 88–100 (Chapman–Hall, London, UK, 1994).
  Book Google Scholar
• Beaumont, M.A. & Nichols, R.A. Evaluating loci for use in the genetic analysis of population structure. Proc. R. Soc. Lond. B 263, 1619–1626 (1996).
  Article Google Scholar
• Holder, A.A. et al. Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites. Nature 317, 270–273 (1985).
  Article CAS Google Scholar
• McBride, J.S. & Heidrich, H.-G. Fragments of the polymorphic Mr 185 000 glycoprotein from the surface of isolated Plasmodium falciparum merozoites form an antigenic complex. Mol. Biochem. Parasitol. 23, 71–84 (1987).
  Article CAS Google Scholar
• Blackman, M.J., Heidrich, H.-G., Donachie, S., McBride, J.S. & Holder, A.A. A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies. J. Exp. Med. 172, 379–382 (1990).
  Article CAS Google Scholar
• Siddiqui, W.A. et al. Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria. Proc. Natl. Acad. Sci., USA 84, 3014–3018 (1987).
  Article CAS Google Scholar
• Hall, R. et al. Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria. Nature 311, 379–382 (1984).
  Article CAS Google Scholar
• Tanabe, K., Mackay, M., Goman, M. & Scaife, J.G. Allelic dimorphism in a surface antigen gene of the malaria parasite Plasmodium falciparum. J. Mol. Biol. 195, 273–287 (1987).
  Article CAS Google Scholar
• Conway, D.J., Greenwood, B.M. & McBride, J.S. Longitudinal study of Plasmodium falciparum polymorphic antigens in a malaria endemic population. Infect. Immun. 60, 1122–1127 (1992).
  CAS PubMed PubMed Central Google Scholar
• Ferreira, M.U. et al. Stable patterns of allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from southern Vietnam. J. Euk. Microbiol. 45, 131–136 (1998).
  Article CAS Google Scholar
• Conway, D.J. et al. High recombination rate in natural populations of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 96, 4506–4511 (1999).
  Article CAS Google Scholar
• Weir, B.S. & Cockerham, C.C. Estimating F statistics for the analysis of population structure. Evolution 38, 1358–1370 (1984).
  CAS Google Scholar
• Su, X.-Z. & Wellems, T.E. Towards a high resolution Plasmodium falciparum linkage map: Polymorphic markers from hundreds of simple sequence repeats. Genomics 33, 430–444 (1996).
  Article CAS Google Scholar
• Anderson, T.J.C., Su, X.-Z., Bockaire, M., Lagog, M. & Day, K.P. Twelve microsatellite markers for characterisation of Plasmodium falciparum from finger prick blood samples. Parasitology 119, 113–125 (1999).
  Article CAS Google Scholar
• Sakihama, N. et al. Allelic recombination and linkage disequilibrium within Msp-1 of Plasmodium falciparum, the malignant human malaria parasite. Gene 230, 47–54 (1999).
  Article CAS Google Scholar
• Locher, C.P., Tam, L.Q., Chang, S.P., McBride, J.S. & Siddiqui, W.A. Plasmodium falciparum : gp195 tripeptide repeat-specific monoclonal antibody inhibits parasite growth in vitro. Exp. Parasitol. 84, 74–83 (1996).
  Article CAS Google Scholar
• Miller, L.H., Roberts, T., Shahabuddin, M. & McCutchan, T.F. Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1). Mol. Biochem. Parasitol. 59, 1–14 (1993).
  Article CAS Google Scholar
• Cavanagh, D.R. & McBride, J.S. Antigenicity of recombinant proteins derived from Plasmodium falciparum merozoite surface protein 1. Mol. Biochem. Parasitol. 85, 197–211 (1997).
  Article CAS Google Scholar
• Cavanagh, D.R. et al. A longitudinal study of type-specific antibody responses to Plasmodium falciparum merozoite surface protein-1 in an area of unstable malaria in Sudan. J. Immunol. 161, 347–359 (1998).
  CAS PubMed Google Scholar
• D'cAlessandro, U. et al. Efficacy trial of the malaria vaccine SPf66 in Gambian infants. Lancet 346, 462–467 (1995).
  Article Google Scholar
• Riley, E.M. et al. Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity. Parasite Immunol. 14, 321–337 (1992).
  Article CAS Google Scholar
• Al-Yaman, F. et al. Assessment of the role of naturally acquired antibody levels to Plasmodium falciparum merozoite surface protein-1 in protecting Papua New Guinean children from malaria mortality. Am. J. Trop. Med. Hyg. 54, 443–448 (1996).
  Article CAS Google Scholar
• Egan, A.F. et al. Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19kDa C-terminal fragment of the merozoite surface antigen, PfMSP1. J. Infect. Dis. 173, 765–769 (1996).
  Article CAS Google Scholar
• Dodoo, D. et al. Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria. Infect. Immun. 67, 2131–2137 (1999).
  CAS PubMed PubMed Central Google Scholar
• Morgan, W.D. et al. Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1. J. Mol. Biol. 289, 113–122 (1999).
  Article CAS Google Scholar
• Patino, J.A., Holder, A.A., McBride, J.S. & Blackman, M.J. Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J. Exp. Med. 186, 1689–1699 (1997).
  Article CAS Google Scholar
• Gupta, S. et al. The maintenance of strain structure in populations of recombining infectious agents. Nature Med. 2, 437–442 (1996).
  Article CAS Google Scholar
• Hastings, I. Population genetics and the detection of immunogenic and drug-resistant loci in Plasmodium. Parasitol. 112, 155–164 (1996).
  Article Google Scholar
• Conway, D.J., Greenwood, B.M. & McBride, J.S. The epidemiology of multiple-clone Plasmodium falciparum infections in Gambian patients. Parasitology 103, 1–6 (1991).
  Article Google Scholar
• Kaneko, O., Kimura, M., Kawamoto, F., Ferreira, M.U. & Tanabe, K. Plasmodium falciparum: Allelic variation in the merozoite surface protein 1 gene in wild isolates from southern Vietnam. Exp. Parasitol. 86, 45–57 (1997).
  Article CAS Google Scholar
• Burghaus, P.A. & Holder, A.A. Expression of the 19-kilodalton carboxy-terminal fragment of the Plasmodium falciparum merozoite surface protein-1 in Escherichia coli as a correctly folded protein. Mol. Biochem. Parasitol. 64, 165–169 (1994).
  Article CAS Google Scholar
• Egan, A.F. et al. Serum antibodies from malaria-exposed people recognize conserved epitopes formed by the two epidermal growth factor motifs of MSP1(19), the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum. Infect. Immun. 63, 456–466 (1995).
  CAS PubMed PubMed Central Google Scholar