Gene-expression profile of the ageing brain in mice (original) (raw)

References

1. Morrison, J.H. & Hof, P.R. Life and death of neurons in the aging brain. Science 278, 412–419 (1997).
   Article CAS Google Scholar
2. Finch, C.E. & Roth, G.S. in Basic Neurochemistry (eds Seigel, G., Agranoff, J.B., Albers, W.R.W., Fisher, S.K. & Uhler, M.D.) 613–633 (Lippincott-Raven, Philadelphia, 1999).
   Google Scholar
3. Gaubatz, J.W. in Molecular Basis of Aging (ed. Macieira-Coelho, A.) 71–182 (CRC Press, Boca Raton, 1995).
   Google Scholar
4. McEwen, B.S. Stress and the aging hippocampus. Front. Neuroendocrinol. 20, 49–70 (1998).
   Article Google Scholar
5. Sohal, R.S. & Weindruch, R. Oxidative stress, caloric restriction, and aging. Science 273, 59–63 (1996).
   Article CAS Google Scholar
6. Disterhoft, J.F., Gispen, W.H., Traber, J. & Khachaturian, Z.F. Calcium Hypothesis of Aging and Dementia (New York Academy of Sciences Press, New York, 1994).
   Google Scholar
7. Blumenthal, H.T. Fidelity assurance mechanisms of the brain with special reference to its immunogenic CNS compartment: their role in aging and aging-associated neurological disease. J. Gerontol. Biol. Sci. Med. Sci. 52, B1–B9 (1997).
   Article CAS Google Scholar
8. Weindruch, R. & Walford, R.L. The Retardation of Aging and Disease by Dietary Restriction (C.C. Thomas, Springfield, Illinois, 1988).
   Google Scholar
9. Ingram, D.K., Weindruch, R., Spangler, E.L., Freeman, J.R. & Walford, R.L. Dietary restriction benefits learning and motor performance of aged mice. J. Gerontol. 42, 78–81 (1987).
   Article CAS Google Scholar
10. Moroi-Fetters, S.E., Mervis, R.F., London, E.D. & Ingram, D.K. Dietary restriction suppresses age-related changes in dendritic spines. Neurobiol. Aging 10, 317–322 (1989).
    Article CAS Google Scholar
11. Duan, W. & Mattson, M.P. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J. Neurosci. Res. 57, 195–206 (1999).
    Article CAS Google Scholar
12. Suo, Z. et al. Alzheimer's β-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40. Brain Res. 807, 110–117 (1998).
    Article CAS Google Scholar
13. Hallgren, R., Terent, A. & Venge, P. Lactoferrin, lysozyme, and β 2-microglobulin levels in cerebrospinal fluid: differential indices of CNS inflammation. Inflammation 6, 291–304 (1982).
    Article CAS Google Scholar
14. Huang, J. et al. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Science 285, 595–599 (1999).
    Article CAS Google Scholar
15. Pasinetti, G.M., Hassler, M., Stone, D. & Finch, C.E. Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions. Synapse 31, 278–284 (1999).
    Article CAS Google Scholar
16. Lemere, C.A. et al. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am. J. Pathol. 146, 848–860 (1995).
    CAS PubMed PubMed Central Google Scholar
17. Hermann, D.M., Mies, G. & Hossmann, K.A. Expression of c-Fos, JunB, c-Jun, MKP-1 and HSP72 following traumatic neocortical lesions in rats—relation to spreading depression. Neuroscience 88, 599–608 (1999).
    Article CAS Google Scholar
18. Nichols, N.R., Day, J.R., Laping, N.J., Johnson, S.A. & Finch, C.E. GFAP mRNA increases with age in rat and human brain. Neurobiol. Aging 14, 421–429 (1993).
    Article CAS Google Scholar
19. Fox, J.W. et al. Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia. Neuron 21, 1315–1325 (1998).
    Article CAS Google Scholar
20. Mattson, M.P. et al. Cellular signaling roles of TGF β, TNFα and β APP in brain injury responses and Alzheimer's disease. Brain Res. Rev. 23, 47–61 (1997).
    Article CAS Google Scholar
21. Kaltschmidt, B., Sparna, T. & Kaltschmidt, C. Activation of NF—B by reactive oxygen intermediates in the nervous system. Antioxidants Redox Signalling 1, 129–144 (1999).
    Article CAS Google Scholar
22. Ryseck, R.P., Weih, F., Carrasco, D. & Bravo, R. RELB, a member of the REL/NF—B family of transcription factors. Braz. J. Med. Biol. Res. 29, 895–903 (1996).
    CAS PubMed Google Scholar
23. Rogers, J. et al. Inflammation and Alzheimer's disease pathogenesis. Neurobiol. Aging 17, 681–686 (1996).
    Article CAS Google Scholar
24. Lee, C.-K., Klopp, R.G, Weindruch, R. & Prolla, T.A. Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390–1393 (1999).
    Article CAS Google Scholar
25. Heid, C.A., Stevens, J., Livak, K.J. & Williams, P.M. Real time quantitative PCR. Genome Res. 6, 986–994 (1996).
    Article CAS Google Scholar
26. Lipshutz, R.J., Fodor, S.P., Gingeras, T.R. & Lockhart, D.J. High density synthetic oligonucleotide arrays. Nature Genet. 21, 20–24 (1999).
    Article CAS Google Scholar

Download references