The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes (original) (raw)
Terwilliger, J.D. & Weiss, K.M. Linkage disequilibrium mapping of complex disease: fantasy or reality? Curr. Opin. Biotechnol.9, 578–594 ( 1998). ArticleCASPubMed Google Scholar
Wright, A.F., Carothers, A.D. & Pirastu, M. Population choice in mapping genes for complex diseases . Nature Genet.23, 397– 404 (1999). ArticleCASPubMed Google Scholar
de la Chapelle, A. & Wright, F.A. Linkage disequilibrium mapping in isolated populations: the example of Finland revisited. Proc. Natl Acad. Sci. USA95, 12416– 12423 (1998). ArticleCASPubMedPubMed Central Google Scholar
Peltonen, L., Jalanko, A. & Varilo, T. Molecular genetics of the Finnish disease heritage. Hum. Mol. Genet.8, 1913–1923 (1999). ArticleCASPubMed Google Scholar
Escamilla, M.A. et al. Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18. Am. J. Hum. Genet.64, 1670 –1678 (1999). ArticleCASPubMedPubMed Central Google Scholar
Ghosh, S. et al. Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc. Natl Acad. Sci. USA96, 2198–2203 (1999). ArticleCASPubMedPubMed Central Google Scholar
Pajukanta, P. et al. Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. Am. J. Hum. Genet.64, 1453–1463 (1999). ArticleCASPubMedPubMed Central Google Scholar
Risch, N. & Merikangas, K. The future of genetic studies of complex human diseases. Science273, 1516–1517 (1996). ArticleCASPubMed Google Scholar
Collins, F.S., Guyer, M.S. & Charkravarti, A. Variations on a theme: cataloging human DNA sequence variation. Science278, 1580– 1581 (1997). ArticleCASPubMed Google Scholar
Kruglyak, L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nature Genet.22, 139– 144 (1999). ArticleCASPubMed Google Scholar
Todd, J.A. Multifactorial diseases: ancient gene polymorphism at quantitative trait loci and a legacy of survival during our evolution. in The Metabolic and Molecular Bases of Inherited Disease (eds Scriver, C.R. et al.) (McGraw-Hill, New York-London, in press).
Laan, M. & Paabo, S. Demographic history and linkage disequilibrium in human populations. Nature Genet.17, 435–438 (1997). ArticleCASPubMed Google Scholar
Jorde, L.B., Watkins, W.S., Kere, J., Nyman, D. & Eriksson, A.W. Gene mapping in isolated populations: new roles for old friends? Hum. Hered.50, 57– 65 (2000). ArticleCASPubMed Google Scholar
Merriman, T. et al. Evidence by allelic-association dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21. Hum. Mol. Genet.6, 1003–1010 ( 1997). ArticleCASPubMed Google Scholar
Merriman, T.R. et al. Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6). Hum. Mol. Genet.7, 517– 524 (1998). ArticleCASPubMed Google Scholar
Lewontin, R.C. The interaction of selection and linkage. I. General considerations; heterotic models. Genetics49, 49– 67 (1964). CASPubMedPubMed Central Google Scholar
Collins, A., Lonjou, C. & Morton, N.E. Genetic epidemiology of single-nucleotide polymorphisms . Proc. Natl Acad. Sci. USA96, 15173– 15177 (1999). ArticleCASPubMedPubMed Central Google Scholar
Huttley, G.A., Smith, M.W., Carrington, M. & O'Brien, S.J. A scan for linkage disequilibrium across the human genome. Genetics152, 1711–1722 ( 1999). CASPubMedPubMed Central Google Scholar
Reed, P.W. et al. Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nature Genet.7, 390–395 (1994). ArticleCASPubMed Google Scholar
Weir, B.S. Genetic Data Analysis (Sinauer Associates, Sunderland, Massachusetts, 1996).