The NOTCH4 locus is associated with susceptibility to schizophrenia (original) (raw)

Nature Genetics volume 25, pages 376–377 (2000)Cite this article

Abstract

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A→G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

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Acknowledgements

We thank H. Hillman, R. Masters and I. Kilbourn for the collection of blood samples from family members; and A. Gliddon, P. Douglas, V. Hanson and L. Hughes for help.

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Authors and Affiliations

  1. Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd, UK
    Jun Wei & Gwynneth P. Hemmings

Authors

  1. Jun Wei
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  2. Gwynneth P. Hemmings
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Correspondence toJun Wei.

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Wei, J., Hemmings, G. The NOTCH4 locus is associated with susceptibility to schizophrenia .Nat Genet 25, 376–377 (2000). https://doi.org/10.1038/78044

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