Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass (original) (raw)
Krude, H. et al. Severe early onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet.19, 155–157 ( 1998). ArticleCAS Google Scholar
Chagnon, Y.C. et al. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the quebec family study. Mol. Med.3, 663–673 ( 1997). ArticleCAS Google Scholar
Yeo, G.S.H. et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genet.20, 111–112 (1998). ArticleCAS Google Scholar
Vaisse, C., Clement, K., Guy-Grand, B. & Froguel, P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genet.20, 113– 114 (1998). ArticleCAS Google Scholar
Michaud, E.J. et al. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc. Natl Acad. Sci. USA91, 2562–2566 (1994). ArticleCAS Google Scholar
Ollmann, M.M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science278, 135–138 (1997). ArticleCAS Google Scholar
Graham, M., Shutter, J.R., Sarmiento, U., Sarosi, I. & Stark, K.L. Overexpression of Agrt leads to obesity in transgenic mice. Nature Genet.17, 273–274 (1997). ArticleCAS Google Scholar
Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell88, 131– 141 (1997). ArticleCAS Google Scholar
Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J. & Cone, R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature385, 165–168 (1997). ArticleCAS Google Scholar
Lu, D. et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature371, 799– 802 (1994). ArticleCAS Google Scholar
Marsh, D.J. et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nature Genet.21, 119–122 (1999). ArticleCAS Google Scholar
Chen, A.S. et al. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res. (in press).
Roselli-Rehfuss, L. et al. Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc. Natl Acad. Sci. USA90, 8856– 8860 (1993). ArticleCAS Google Scholar
Johnson, P.R. & Hirsch, J. Cellularity of adipose depots in six strains of genetically obese mice. J. Lipid Res.13, 2–11 (1972). CASPubMed Google Scholar
Yen, T.T., Allan, J.A., Yu, P.-L., Acton, M.A. & Pearson, D.V. Triacylglycerol contents and in vivo lipogenesis of ob/ob, db/db and Avy/a mice. Biochem. Biophys. Acta441, 213–220 ( 1976). ArticleCAS Google Scholar
Yen, T.T., Steinmetz, J. & Wolff, G.L. Lipolysis in genetically obese and diabetes-prone mice. Horm. Metab. Res.2, 200– 203 (1970). ArticleCAS Google Scholar
Jones, B.H. et al. Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am. J. Physiol.270, E192–E196 (1996). ArticleCAS Google Scholar
Xue, B., Moustaid-Moussa, N., Wilkison, W.O. & Zemel, M.B. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. FASEB12, 1391–1396 (1998). ArticleCAS Google Scholar
Fekete, C. et al. α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J. Neurosci.20, 1550–1558 ( 2000). ArticleCAS Google Scholar
Kim, M.S. et al. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J. Clin. Invest.105, 1005–1011 ( 2000). ArticleCAS Google Scholar
Frigeri, L.G., Wolff, G.L. & Teguh, C. Differential responses of yellow Avy/A and agouti A/a (BALB/c×VY) F1 hybrid mice to the same diets: glucose tolerance, weight gain, and adipocyte cellularity. Int. J. Obes.12, 305–320 ( 1988). CASPubMed Google Scholar
Shimizu, H., Shargill, N.S., Bray, G.A., Yen, T.T. & Geselichen, P.D. Effects of MSH on food intake, body weight and coat color of the yellow obese mouse. Life Sci.45, 543–552 ( 1989). ArticleCAS Google Scholar
Hruby, V.J. et al. Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7, Lys10] α-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem.38 , 3454–3461 (1995). ArticleCAS Google Scholar
Bagnol, D. et al. Anatomy of an endogenous antagonist: relationship between agouti-related protein and proopiomelanocortin in brain. J. Neurosci.19, RC26 (1–7) (1999). ArticleCAS Google Scholar
Gantz, I. et al. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem.268, 8246–8250 (1993). CASPubMed Google Scholar
Chhajlani, V. Distribution of cDNA for melanocortin receptor subtypes in human tissues. Biochem. Mol. Biol. Int.38, 73–80 (1996). CASPubMed Google Scholar
Lembertas, A.V. et al. Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J. Clin. Invest.100, 1240–1247 (1997). ArticleCAS Google Scholar
Guan, X.-M., Yu, H. & Van der Ploeg, L.H.T. Evidence of altered hypothalamic pro-opiomelanocortin/neuropeptide Y mRNA expression in tubby mice. Mol. Brain Res.59 , 273–279 (1998). ArticleCAS Google Scholar
Kelly, T.L., Berger, N. & Richardson, T.L. DXA body composition: theory and practice. Appl. Radiat. Isot.49, 511–513 (1998). ArticleCAS Google Scholar
Ellis, K.J. Human body composition: in vivo methods. Physiol. Rev.80, 649–680 (2000). ArticleCAS Google Scholar