Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis (original) (raw)

References

  1. Bellows, C. G., Wang, Y. -H., Heersche, J. N. M. & Aubin, J. E. 1,25-dihydroxyvitamin D3 stimulates adipocyte differentiation in cultures of fetal rat calvaria cells: comparison with the effects of dexamethasone . Endocrinology 134, 2221– 2229 (1994).
    Article CAS Google Scholar
  2. Grigoriadis, A. E., Schellander, K., Wang, Z-Q. & Wagner, E. F. Osteoblasts are target cells for transformation in c-fos transgenic mice. J. Cell Biol. 122, 685– 701 (1993).
    Article CAS Google Scholar
  3. Wang, Z-Q., Liang, J., Schellander, K., Wagner, E. F. & Grigoriadis, A. E. c-_fos_-induced osteosarcoma formation in transgenic mice: cooperativity with c-jun and the role of endogenous c-fos. Cancer Res. 55, 6244–6251 (1995).
    CAS PubMed Google Scholar
  4. Johnson, R. S., Spiegelman, B. M. & Papaioannou, V. Pleiotropic effects of a null mutation in the c- _fos_proto-oncogene. Cell 71, 577– 586 (1992).
    Article CAS Google Scholar
  5. Wang, Z. -Q., Ovitt, C., Grigoriadis, A. E., Mohle-Steinlein, U., Ruther, U. & Wagner, E. F. Bone and haematopoietic defects in mice lacking c- fos. Nature 360, 741– 745 (1992).
    Article CAS Google Scholar
  6. Gruda, M. C., van Amsterdam, J., Rizzo, C. A., Durham, S. K., Lira, S. & Bravo, R. Expression of FosB during mouse development: normal development of FosB knockout mice. Oncogene 12, 2177– 2185 (1996).
    CAS PubMed Google Scholar
  7. Chen, J., et al. Transgenic animals with inducible, targeted gene expression in brain. Mol. Pharmacol. 54, 495– 503 (1998).
    Article CAS Google Scholar
  8. Kelz, M. B., et al. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 401, 272–276 (1999).
    Article CAS Google Scholar
  9. Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693–702 (1991).
    Article CAS Google Scholar
  10. Hayman, A. R., et al. Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis. Development 122, 3151–3162 ( 1996).
    CAS PubMed Google Scholar
  11. Seifert, M. F. & Marks, S. C. Morphological evidence of reduced bone resorption in the osteosclerotic (oc) mouse . Am. J. Anat. 172, 141– 153 (1985).
    Article CAS Google Scholar
  12. Franzoso, G. L., et al. Requirement for NF-κB in osteoclast and B-cell development . Genes Dev. 11, 3482–3496 (1997).
    Article CAS Google Scholar
  13. Tondravi, M. M., et al. Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature 386, 81– 84 (1997).
    Article CAS Google Scholar
  14. Marks, S. C.,Jr. & Lane, P. W. Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse . J. Hered. 67, 11–18 (1976).
    Article Google Scholar
  15. Simonet, W. S., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density . Cell 89, 309 –319 (1997).
    Article CAS Google Scholar
  16. Ducy, P., et al. Increased bone formation in osteocalcin-deficient mice. Nature 382, 448–452 ( 1996).
    Article CAS Google Scholar
  17. Arneet, R. & Dempster, D. The effect of pH on bone resorption by rat osteoclasts in vitro. Endocrinology 119, 119–124 (1986).
    Article Google Scholar
  18. Anderson, R., Woodbury, D. & Jee, W. Humoral and ionic regulation of osteoclast acidity. Calcif. Tissue Int. 39, 252–258 (1986).
    Article CAS Google Scholar
  19. Ducy, P., et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. 100, 197–207 (2000).
    Article CAS Google Scholar
  20. Chen, J., Kelz, M. B., Hope, B. T., Nakabeppu, Y. & Nestler, E. J. Chronic Fos-related antigens: stable variants of ΔFosB induced in brain by chronic treatments. J. Neurosci. 17, 4933–4941 (1997).
    Article CAS Google Scholar
  21. Dorheim, M. et al. Osteoblastic gene expression during adipogenesis in hematopoietic supporting murine bone marrow stromal cells. J. Cell Physiol. 154, 317–328 (1993).
    Article CAS Google Scholar
  22. McCabe, L. R., et al. Developmental expression and activities of specific Fos and Jun proteins are functionally related to osteoblast maturation: Role of Fra-2 and Jun D during differentiation. Endocrinology 137 , 4398–4408 (1996).
    Article CAS Google Scholar
  23. Liberati, N., et al. Smads bind directly to the Jun family of AP-1 transcription factors. Proc. Natl. Acad. Sci. USA 96, 4844–4849 (1999).
    Article CAS Google Scholar
  24. Owen, T. A., et al. Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription. Proc. Natl. Acad. Sci. USA 87, 9990–9994 (1990).
    Article CAS Google Scholar
  25. Banerjee, C., et al. TGF-β1 response in the rat osteocalcin gene is mediated by an AP-1 binding site. Endocrinology 137, 1991–2000 (1996).
    Article CAS Google Scholar
  26. Distel, R. J., Ro, H. S., Rosen, B. S., Groves, D. L. & Spiegelman, B. M. Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell 49, 835–844 ( 1987).
    Article CAS Google Scholar
  27. Stephens, J. M., Butts, M. D. & Pekala, P. H. Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by tumor necrosis factor-alpha . J. Mol. Endocrinol. 9, 61– 72 (1992).
    Article CAS Google Scholar
  28. Parfitt, A. M., et al. Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR histomorphometry nomenclature committee. J. Bone Miner. Res. 2, 595–610 (1987).
    Article CAS Google Scholar
  29. Bellows, C. G., Heersche, J. N. M. & Aubin, J. E. Determination of the capacity for proliferation and differentiation of osteoprogenitor cells in the presence and absence of dexamethasone . Dev. Biol. 140, 132–138 (1990).
    Article CAS Google Scholar
  30. Quarles, L. D., Yohay, D. A., Lever, L. W., Caton, R. & Wenstrup, R. J. Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development. J. Bone Miner. Res. 7, 683– 692 (1992).
    Article CAS Google Scholar
  31. Cao, Z., Umek, R. M. & McKnight, S. L. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5, 1538–1552 (1991).
    Article CAS Google Scholar
  32. Aoki, K., et al. They tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me v/me v mutant mice. Bone 25, 261–267 (1999).
    Article CAS Google Scholar
  33. Takahashi, N., et al. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122, 1373–1382 (1988).
    Article CAS Google Scholar
  34. Sambrook, J. Fritsch, E. F. & Maniatis, T. Molecular Cloning: A Laboratory Manual 2nd ed. (Cold Spring Harbor Laboratory Press, New York, 1989).
    Google Scholar
  35. Sabatakos, G., Davies, G. E., Grosse, M., Cryer, A. & Ramji, D. P. Expression of the genes encoding CCAAT-enhancer binding protein isoforms in the mouse mammary gland during lactation and involution. Biochem. J. 334, 205–210 (1998).
    Article CAS Google Scholar
  36. Schreiber, E., Matthias, P., Muller, M. M. & Schaffner, W. Rapid detection of octamer binding proteins with ‘mini-extracts’, prepared from a small number of cells. Nucleic Acids Res. 17, 6419 (1989).
    Article CAS Google Scholar
  37. Baron, R., Vignery, A., Neff, L., Silverglate, A. & Maria, A. S. in Bone histomorphometry: technique and interpretation Vol. 1 (ed Recker, R.R.) 13–35 (CRC Press, Boca Raton, Florida, 1983).
    Google Scholar

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