Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo (original) (raw)

References

  1. Tanchot, C., Rosado, M. M., Agenes, F., Freitas, A. A. & Rocha, B. Lymphocyte homeostasis. Semin. Immunol. 9, 331–337 (1997).
    Article CAS Google Scholar
  2. Tanchot, C. & Rocha, B. The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8(+) T cell pools Eur. J. Immunol. 25, 2127–2136 (1995).
    Article CAS Google Scholar
  3. Berzins, S. P., Boyd, R. L. & Miller, J. F. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med. 187, 1839–1848 (1998).
    Article CAS Google Scholar
  4. Tanchot, C., Lemonnier, F.A., Perarnau, B., Freitas, A. A. & Rocha, B. Differential requirements for survival and proliferation of CD8 naïve or memory T cells. Science 276, 2057–2062 (1997).
    Article CAS Google Scholar
  5. Nesic, D. & Vukmanovic, S. MHC class I is required for peripheral accumulation of CD8+ thymic emigrants. J. Immunol. 160, 3705–3712 (1998).
    CAS PubMed Google Scholar
  6. Takeishi, T., Lemonnier, F. A., Perarnau, B., Freitas, A. A. & Rocha, B. MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. Immunity 5, 217–228 (1996).
    Article Google Scholar
  7. Brocker, T. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J. Exp. Med. 186, 1223–1232 (1997).
    Article CAS Google Scholar
  8. Bruno, L., Kirberg, J. & von Boehmer, H. On the cellular basis of immunological T cell memory. Immunity 2, 37–43 (1995).
    Article CAS Google Scholar
  9. Bruno, L., von Boehmer, H. & Kirberg, J. Cell division in the compartment of naïve and memory T lymphocytes. Eur. J. Immunol. 26, 3179–3184 (1996).
    Article CAS Google Scholar
  10. Tough, D. F. & Sprent, J. Turnover of naïve- and memory-phenotype T cells. J. Exp. Med. 179, 1127–1135 (1994).
    Article CAS Google Scholar
  11. Bell, E. B., Sparshott, S. M., Drayson, M. T. & Ford, W. L. The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature cells. J. Immunol. 139, 1379–1384 (1987).
    CAS PubMed Google Scholar
  12. Rocha, B., Dautigny, N. & Pereira, P. Peripheral T lymphocytes:expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur. J. Immunol. 19, 905–911 (1989).
    Article CAS Google Scholar
  13. Goldrath, A. W. & Bevan, M. J. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity 11, 183–190 (2000).
    Article Google Scholar
  14. Ernst, B., Lee, D. -S., Chang, J. M., Sprent, J. & Surh, C. D. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11, 173–181 (2000).
    Article Google Scholar
  15. Kieper, W. C. & Jameson, S. C. Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands. Proc. Natl Acad. Sci. USA 96, 13306–13311 (2000).
    Article Google Scholar
  16. Murali-Krishna, K. et al. Persistence of memory CD8 T cells in MHC class I-deficient mice. Science 286, 1377–1381 (1999).
    Article CAS Google Scholar
  17. Swain, S. L., Hu, H. & Huston, G. Class II-independent generation of CD4 memory T cells from effectors. Science 286, 1381–1383 (1999).
    Article CAS Google Scholar
  18. Ku, C. C., Murakami, M., Sakamoto, A., Kappler, J. & Marrack, P. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288, 675–678 (2000).
    Article CAS Google Scholar
  19. Boursalian, T. E. & Bottomly, K. Survival of naïve CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu. J. Immunol. 162, 3795–3801 (1999).
    CAS PubMed Google Scholar
  20. Lantz, O., Grandjean, I., Matzinger, P. & Di Santo, J. P. γ chain required for naøve CD4+ T cell survival but not for antigen proliferation. Nature Immunol. 1, 54–58 (2000).
    Article CAS Google Scholar
  21. Marrack, P. et al. Homeostasis of αβ TCR+ T cells. Nature Immunol. 1, 107–111 (2000).
    Article CAS Google Scholar
  22. von Freeden-Jeffry, U. et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181, 1519–1526 (1995).
    Article CAS Google Scholar
  23. Grabstein, K. H. et al. Regulation of T cell proliferation by IL-7. J. Immunol. 144, 3015–3020 (1990).
    CAS PubMed Google Scholar
  24. Maraskovsky, E. et al. Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells. J. Immunol. 157, 5315–5323 (1996).
    CAS PubMed Google Scholar
  25. Hassan, J. & Reen, D. J. IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells. Eur. J. Immunol. 28, 3057–3655 (1998).
    Article CAS Google Scholar
  26. Vella, A. T., Teague, T. K., Ihle, J. N., Kappler, J. & Marrack, P. Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J. Exp. Med. 186, 325–330 (1997).
    Article CAS Google Scholar
  27. Kim, S. K., Schluns, K. S. & Lefrançois, L. Induction and visualization of mucosal memory CD8 T cells following systemic virus infection. J. Immunol. 163, 4125–4132 (1999).
    CAS PubMed Google Scholar
  28. Schober, S.L. et al. Expression of the transcription factor Lung Kruppel-Like Factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. J. Immunol. 163, 3662–3667 (1999).
    CAS PubMed Google Scholar
  29. Levin, S. D. et al. Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. J. Immunol. 162, 677–683 (1999).
    CAS PubMed Google Scholar
  30. Kondo, M. et al. Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 262, 1874–1877 (1993).
    Article CAS Google Scholar
  31. Noguchi, M. et al. Interleukin-2 receptor γ chain: a functional component of the interleukin-7 receptor. Science 262, 1877–1800 (1993).
    Article CAS Google Scholar
  32. Pandey, A. et al. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nature Immunol. 1, 59–64 (2000).
    Article CAS Google Scholar
  33. Kim, S.K. et al. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proc. Natl Acad. Sci. USA 95, 10814–10819 (1998).
    Article CAS Google Scholar
  34. Gudmundsdottir, H., Wells, A. D. & Turka, L. A. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 162, 5212–5223 (1999).
    CAS PubMed Google Scholar
  35. Limanni, A. et al. Ligand gene expression in normal and sublethally irradiated mice. Blood 85, 2377–2384 (1995).
    CAS PubMed Google Scholar
  36. Peterson, V. M. et al. Gene expression of hematoregulatory cytokines is elevated endogenously after sublethal gamma irradiation and is differentially enhanced by therapeutic administration of biologic response modifiers. J. Immunol. 153, 2321–2330 (1994).
    CAS PubMed Google Scholar
  37. Harrison, D. E. & Russell, E. S. The response of W/W v and Sl/Sl d anaemic mice to haemopoietic stimuli. Br. J. Haematol. 22, 155–168 (1972).
    Article CAS Google Scholar
  38. Hong, J. H. et al. Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation. Int. J. Radiat. Biol. 75, 1421–1427 (1999).
    Article CAS Google Scholar
  39. Moore, N. C., Anderson, G., Smith, C. A., Owen, J. J. T. & Jenkinson, E. J. Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction. Eur. J. Immunol. 23, 922–927 (1993).
    Article CAS Google Scholar
  40. Funk, P. E., Stephan, R. P. & Witte, P. L. Vascular cell adhesion molecule 1-positive reticular cells express interleukin-7 and stem cell factor in the bone marrow. Blood 86, 2661–2671 (1995).
    CAS PubMed Google Scholar
  41. Sorg, R. V., Mclellan, A. D., Hock, B. D., Fearnley, D. B. & Hart, D. N. Human dendritic cells express functional interleukin-7. Immunobiol. 198, 514–526 (1998).
    Article CAS Google Scholar
  42. Kroncke, R., Loppnow, H., Flad, H. D. & Gerdes, J. Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur. J. Immunol. 26, 2541–2544 (1996).
    Article CAS Google Scholar
  43. Grayson, J. M., Zajac, A. J. A. & Ahmed, R. Increased expression of Bcl-2 in antigen-specific memory CD8+ T cells. J. Immunol. 164, 3950–3954 (2000).
    Article CAS Google Scholar
  44. von Freeden-Jeffry, U., Solvason, N., Howard, M. & Murray, R. The earliest T lineage-committed cells depend on IL-7 for bcl-2 expression and normal cell cycle progression. Immunity 7, 147–154 (1997).
    Article CAS Google Scholar
  45. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. & Weissman, I.L. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89, 1033–1041 (1997).
    Article CAS Google Scholar
  46. Kim, K., Lee, C. K., Sayers, T. J., Muegge, K. & Durum, S. K. The trophic action of IL-7 on pro-T cells: inhibition of apoptosis pro-T1, -T2, and T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways. J. Immunol. 160, 5735–5741 (1998).
    CAS PubMed Google Scholar
  47. Moore, T. A., von Freeden-Jeffry, U., Murray, R. & Zlotnik, A. Inhibition of γδ T cell development and early thymocyte maturation in IL-7−/− mice. J. Immunol. 157, 2366–2373 (1996).
    CAS PubMed Google Scholar
  48. Kuo, C. T., Veselits, M. L. & Leiden, J. M. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science 277, 1986–900 (1997).
    Article CAS Google Scholar
  49. Zhang, X., Sun, S., Hwang, I., Tough, D. F. & Sprent, J. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8, 591–599 (1998).
    Article CAS Google Scholar
  50. Lodolce, J. P. et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9, 669–676 (1998).
    Article CAS Google Scholar
  51. Kennedy, M. K. et al. Reversible defects in natural killer and memory CD8 T cell lineages in Interleukin-15-deficient mice. J. Exp. Med. 191, 771–780 (2000).
    Article CAS Google Scholar
  52. Watanabe, M. et al. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 95, 2945–2953 (1995).
    Article CAS Google Scholar
  53. Wiles, M. V., Ruiz, P. & Imhof, B. A. Interleukin-7 expression during mouse thymus development. Eur. J. Immunol. 22, 1037–1042 (1992).
    Article CAS Google Scholar
  54. Bender, J. R., Mitchell, T., Kappler, J. & Marrack, P. CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection. J. Exp. Med. 190, 367–374 (1999).
    Article CAS Google Scholar
  55. Ariel, A. et al. Induction of T cell adhesion to extracellular matrix or endothelial cell ligands by soluble or matrix-bound interleukin-7. Eur. J. Immunol. 27, 2562–2570 (1997).
    Article CAS Google Scholar
  56. Peschon, J. J. et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955–1960 (1994).
    Article CAS Google Scholar
  57. Hogquist, K. A. et al. T cell receptor antagonistic peptides induce positive selection. Cell 76, 17–27 (1994).
    Article CAS Google Scholar
  58. Sarmiento, M., Glasebrook, A. L. & Fitch, F. W. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt-2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125, 2665–2672 (1980).
    CAS PubMed Google Scholar
  59. Shen, F. W. in Monoclonal Antibodies and T-cell Hybridomas. Perspectives and technical advances (eds Hammerling, G. J., Hammerling, U. & Kearney, J. F.) 25–31 (Elsevier/North-Holland Inc., Amsterdam, 1981).
    Google Scholar
  60. Suda, T. et al. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl Acad. Sci. USA 90, 9125–9129 (1993).
    Article Google Scholar

Download references