Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte (original) (raw)
References
Wang, S. D., Huang, K. J., Lin, Y. S. & Lei, H. Y. Sepsis-induced apoptosis of the thymocytes in mice. J. Immunol.152 , 5014–5021 (1994). CASPubMed Google Scholar
Ayala, A., Herndon, C., Lehman, D. & Chaudry, I. H. Differential induction of apoptosis in lymphoid tissue during sepsis: variation in onset, frequency and nature of the mediators. Blood87, 4261–4275 (1996). CASPubMed Google Scholar
Hotchkiss, R. S. et al. Apoptosis in lymphoid and parenchymal cells during sepsis: Findings in normal and T- and B-cell deficient mice. Crit. Care Med.25, 1298–1307 ( 1997). ArticleCAS Google Scholar
Hotchkiss, R. S. et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit. Care Med.27, 1230 –1251 (1999). ArticleCAS Google Scholar
Thornberry, N. A. & Lazebnik, Y. Caspases: enemies within. Science281, 1312– 1316 (1998). ArticleCAS Google Scholar
Nicholson, D. W. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ.6, 1028– 1042 (1999). ArticleCAS Google Scholar
Endres, M. et al. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J. Cere. Blood Flow Metabol.18, 238–247 ( 1988). Article Google Scholar
Fukuzuka, K. et al. Caspase-3-dependent organ apoptosis early after burn injury . Ann. Surg.229, 851–858 (1999). ArticleCAS Google Scholar
Grobmeyer, S. R. et al. Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock. Mol. Med.5, 585– 594 (1999). Article Google Scholar
Hotchkiss, R. S. et al. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc. Natl Acad, Sci. USA96, 14541 –14546 (1999). ArticleCAS Google Scholar
Varfolomeev, E. E. et al. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1 and DR3 and is lethal prenatally . Immunity9, 267–276 (1998). ArticleCAS Google Scholar
Kuida, K. et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell94, 325– 337 (1998). ArticleCAS Google Scholar
Hakem, R. et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell94, 339– 352 (1998). ArticleCAS Google Scholar
Zheng, T. S., Hunot, S., Kuida, K. & Flavell, R. A. Caspase knockouts: matters of life and death. Cell Death Differ.6, 1043–1053 (1999). ArticleCAS Google Scholar
Kuida, K. et al. Decrease apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature384, 368–372 (1996). ArticleCAS Google Scholar
Woo, M. et al. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev.12, 806–819 (1998). ArticleCAS Google Scholar
Garcia-Calvo, M. et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J. Biol. Chem.273, 32608– 32613 (1998). ArticleCAS Google Scholar
Baker, C. C., Chaudry, I. H., Gains, H. O. & Baue, A. E. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture mode. Surgery94, 331–335 (1983). CASPubMed Google Scholar
Remick, D. G., Newcomb, D. E., Bolgos, G. L. & Call, D. R. Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide versus cecal ligation and puncture. Shock13, 110–116 ( 2000). ArticleCAS Google Scholar
Hotchkiss, R. S. et al. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J. Immunol.162, 4148–4156 (1999). CASPubMed Google Scholar
Hotchkiss, R. S. et al. Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole. Am. J. Physiol.30, 965–972 (1991). Google Scholar
Janicke, R. U., Sprengart, M. L., Wati, M. R. & Porter, A. G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem.273, 9357 –9360 (1998). ArticleCAS Google Scholar
Medzhitov, R., Janeway, C. Innate immunity. N. Engl. J. Med.343, 338–344 ( 2000). ArticleCAS Google Scholar
Abbas, A. K., Lichtman, A. H. & Pober, J. S. in Cellular and Molecular Immunology 4th edn, 4 (W. B. Saunders Co., Philadelphia, 2000). Google Scholar
Janeway, C. A., Travers, P., Walport, M. & Capra, J. D. in Immunobiology: The immune system in health and disease 4th edn, 219 (Current Biology Publications, London, 1999). Google Scholar
Braun, J. S. et al. Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nature Med.5, 298– 302. (1999). ArticleCAS Google Scholar
Oberholzer, A., Oberholzer, C. & Moldawer, L. L. Cytokine signaling- regulation of the immune system in normal and critically ill states. Crit. Care Med.28, S3 (2000). Article Google Scholar
Yagupsky, P. & Notte, F. S. Quantitative aspects of septicemia . Clin. Microbiol. Rev.3, 269– 279 (1990) ArticleCAS Google Scholar
Bell, L. M., Alpert, G., Campos, J. M. & Plotkin, S. A. Routine quantitative blood cultures in children with Haemophilus influenzae or Streptococcus pneumoniae bacteremia. Pediatrics76, 901–904 ( 1985). CASPubMed Google Scholar
Goronzy, J., Weyand, C., Quan, J., Fathman, C. G. & O'Hanley, P. Enhanced cell-mediated protection against fatal Escherichia coli septicemia induced by treatment with recombinant IL-2 . J. Immunol.142, 1134– 1138 (1989). CASPubMed Google Scholar
Docke, W. E. et al. Monocyte deactivation in septic patients: restoration by IFN-γ treatment. Nature Med.3, 678– 681 (1997). ArticleCAS Google Scholar
Garcia-Calvo et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors . J. Biol. Chem.273, 32608– 32613 (1998). ArticleCAS Google Scholar
Garcia-Calvo, M. et al. Purification and catalytic properties of human caspase family members. Cell Death Differ6, 362– 369 (1999). ArticleCAS Google Scholar