Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 (original) (raw)

• Ferrara, N. & Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr. Rev. 18, 4– 25 (1997).
  Article CAS Google Scholar
• Isner, J.M. & Takayuki, A. Therapeutic angiogenesis. Front. Biosci. 3, e49–69 (1998).
  Article CAS Google Scholar
• Klagsbrun, M. & D'Amore, P.A. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev. 7, 259–270 (1996).
  Article CAS Google Scholar
• Dvorak, H.F., Brown, L.F., Detmar, M. & Dvorak, A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029 –1039 (1995).
  CAS PubMed Google Scholar
• Neufeld, G., Cohen, T., Gengrinovitch, S. & Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9–22 ( 1999).
  Article CAS Google Scholar
• Keyt, B.A. et al. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem. 271, 7788–7795 ( 1996).
  Article CAS Google Scholar
• Cheung, N., Wong, M.P., Yuen, S.T., Leung, S.Y. & Chung, L.P. Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon. Hum. Pathol. 29, 910–914 (1998).
  Article CAS Google Scholar
• Soker, S., Takashima, S., Miao, H.Q., Neufeld, G. & Klagsbrun, M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform- specific receptor for vascular endothelial growth factor. Cell 92, 735– 745 (1998).
  Article CAS Google Scholar
• Takeshita, S. et al. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Lab. Invest. 75, 487–501 (1996).
  CAS PubMed Google Scholar
• Cheng, S.Y., Nagane, M., Huang, H.S. & Cavenee, W.K. Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189. Proc. Natl. Acad. Sci. USA 94, 12081–12087 (1997).
  Article CAS Google Scholar
• Tokunaga, T. et al. Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. Br. J. Cancer 77, 998– 1002 (1998).
  Article CAS Google Scholar
• Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single vascular endothelial growth factor allele. Nature 380, 435–439 ( 1996).
  Article CAS Google Scholar
• Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439– 442 (1996).
  Article CAS Google Scholar
• Shima, D.T. et al. The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. J. Biol Chem. 271, 3877–3883 (1996).
  Article CAS Google Scholar
• Flameng, W. et al. Relation between coronary artery stenosis and myocardial purine metabolism, histology and regional function in humans. J. Am. Coll. Cardiol. 9, 1235–1242 ( 1987).
  Article CAS Google Scholar
• Vanoverschelde, J.L.J. et al. Chronic myocardial hibernation in humans. From bedside to bench. Circulation 95, 1961– 1971 (1997).
  Article CAS Google Scholar
• Elsässer, A. & Schaper, J. Hibernating myocardium: adaptation or degeneration? Basic Res. Cardiol. 90, 47–48 (1995).
  PubMed Google Scholar
• Kloner, R.A., Bolli, R., Marban, E., Reinlib, L. & Braunwald, E. Medical and cellular implications of stunning, hibernation and preconditioning. An NHLBI workshop. Circulation 97, 1848–1867 (1998).
  Article CAS Google Scholar
• Borgers, M. in Stunning, Hibernation, and Preconditioning: Clinical Pathophysiology of Myocardial Ischemia. (eds. Heyndrickx, G.R., Vatner, S.F. & Wijns, W.) 287–306 (Lippincott-Raven, Philadelphia, 1997).
  Google Scholar
• Schwarz, E.R. et al. Myocyte degeneration and cell death in hibernating human myocardium. J. Am. Coll. Cardiol. 27, 1577– 1585 (1996).
  Article CAS Google Scholar
• Shivalkar, B. et al. Only hibernating myocardium invariably shows early recovery after coronary revascularization. Circulation 94, 308–315 (1996).
  Article CAS Google Scholar
• Chen, C. et al. Myocardial cell death and apoptosis in hibernating myocardium. J. Am. Coll. Cardiol. 30, 1407– 1412 (1997).
  Article CAS Google Scholar
• Shivalkar, B. Chronic Reversible Myocardial Dysfunction: Clinical and Experimental Studies (PhD thesis, Acta Biomedica Lovaniensa, Leuven University Press, 1998) 1–130 (see attached copies in fax dd April 2nd 1999).
• Hudlicka, O. & Brown, M.D. Postnatal growth of the heart and its blood vessels. J. Vasc. Res. 33, 266 –287 (1996).
  Article CAS Google Scholar
• Tomanek, R.J. Formation of the coronary vasculature: a brief review. Cardiovasc. Res. 31, E46–51 ( 1996).
  Article Google Scholar
• Hirschi, K.K., Rohovsky, S.A. & D'Amore, P.A. PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate [published erratum in J. Cell Biol. 141 , 1287 (1998)]. J. Cell. Biol. 141, 805–814 (1998).
  Article CAS Google Scholar
• Koblizek, T.I., Weiss, C., Yancopoulos, G.D., Deutsch, U. & Risau, W. Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr. Biol. 8, 529– 532 (1998).
  Article CAS Google Scholar
• Suri, C. et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171–1180 (1996).
  Article CAS Google Scholar
• Evans, S.M. et al. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 (2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide). Br. J. Cancer 72, 875– 882 (1995).
  Article CAS Google Scholar
• Carmeliet, P. et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. Nature 394, 485– 490 (1998).
  Article CAS Google Scholar
• Zareba, W., Moss, A.J. & le Cessie, S. Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. Am. J. Cardiol. 74, 550–553 (1994).
  Article CAS Google Scholar
• Kaprielian, R.R. et al. Downregulation of immunodetectable connexin 43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation 97, 651– 660 (1998).
  Article CAS Google Scholar
• Schaper, J. et al. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation 83, 504–514 (1991).
  Article CAS Google Scholar
• Elsässer, A. et al. Hibernating myocardium. An incomplete adaptation to ischemia. Circulation 96, 2920–2931 (1997).
  Article Google Scholar
• Ausma, J. et al. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation 96, 3157–3163 (1997).
  Article CAS Google Scholar
• Lopaschuk, G.D., Collins-Nakai, R.L. & Itoi, T. Developmental changes in energy substrate use by the heart. Cariovasc. Res. 26, 1172– 1180 (1992).
  Article CAS Google Scholar
• Murda'h, M.A., McKenna, W.J. & Camm, A.J. Repolarization alternans: techniques, mechanisms, and cardiac vulnerability. Pacing Clin. Electrophysiol. 20, 2641–2657 (1997).
  Article CAS Google Scholar
• Shaw, D.B., Linker, N.J., Heaver, P.A. & Evans, R. Chronic sinoatrial disorder (sick sinus syndrome): a possible result of cardiac ischaemia. Br. Heart J. 58, 598– 607 (1987).
  Article CAS Google Scholar
• Lopaschuk, G.D. & Stanley, W.C. Glucose metabolism in the ischemic heart. Circulation 85, 313 –315 (1997).
  Article Google Scholar
• Kremer, C., Breier, G., Risau, W. & Plate, K.H. Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system. Cancer Res. 57, 3852–3859 (1997).
  CAS PubMed Google Scholar
• Risau, W. Development and differentiation of endothelium. Kidney Int. Suppl. 67, S3–6 (1998 ).
  Article CAS Google Scholar
• Witzenbichler, B. et al. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. Am. J. Pathol. 153, 381–394 ( 1998).
  Article CAS Google Scholar
• Gerber, H.P., Condorelli, F., Park, J. & Ferrara, N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272, 23659–23667 (1997).
  Article CAS Google Scholar
• Carmeliet, P. et al. Role of tissue factor in embryonic blood vessel development. Nature 383, 73–75 (1996).
  Article CAS Google Scholar
• Arber, S. et al. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell 88, 393–403 (1997).
  Article CAS Google Scholar