Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31 (original) (raw)

• Hanahan, D. & Weinberg, R.A. The hallmarks of cancer. Cell 100, 57–70 (2000).
  Article CAS Google Scholar
• Kibbelaar, R.E. et al. Detection of monosomy 7 and trisomy 8 in myeloid neoplasia: a comparison of banding and fluorescence in situ hybridization. Blood 82, 904–913 (1993).
  CAS PubMed Google Scholar
• Abrahamson, G.M. et al. Comparison of cytogenetic and restriction fragment length polymorphism analyses for the detection of loss of chromosome material in clonal hemopoietic disorders. Am. J. Hematol. 42, 171–176 (1993).
  Article CAS Google Scholar
• Gupta, P.K. et al. High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination. Cancer Res. 57, 1188–1193 (1997).
  CAS PubMed Google Scholar
• Zenklusen, J.C. & Conti, C.J. Cytogenetic, molecular and functional evidence for novel tumor suppressor genes on the long arm of human chromosome 7. Mol. Carcinog. 15, 167–175 (1996).
  Article CAS Google Scholar
• Bieche, I. et al. Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. Lancet 339, 139–143 (1992).
  Article CAS Google Scholar
• Zenklusen, J.C., Bieche, I., Lidereau, R. & Conti, C.J. (C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer. Proc. Natl. Acad. Sci. USA 91, 12155–12158 (1994).
  Article CAS Google Scholar
• Zenklusen, J.C., Thompson, J.C., Troncoso, P., Kagan, J. & Conti, C.J. Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. Cancer Res. 54, 6370–6373 (1994).
  CAS PubMed Google Scholar
• Cunningham, J.M. et al. Allelic imbalance and microsatellite instability in prostatic adenocarcinoma. Cancer Res. 56, 4475–4482 (1996).
  CAS PubMed Google Scholar
• Koike, M. et al. Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer. Genes Chromosomes Cancer 19, 1–5 (1997).
  Article CAS Google Scholar
• Zenklusen, J.C., Weitzel, J.N., Ball, H.G. & Conti, C.J. Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene. Oncogene 11, 359–363 (1995).
  CAS PubMed Google Scholar
• Zenklusen, J.C., Thompson, J.C., Klein-Szanto, A.J. & Conti, C.J. Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res. 55, 1347–1350 (1995).
  CAS PubMed Google Scholar
• Nishizuka, S., Tamura, G., Terashima, M. & Satodate, R. Commonly deleted region on the long arm of chromosome 7 in differentiated adenocarcinoma of the stomach. Br. J. Cancer 76, 1567–1571 (1997).
  Article CAS Google Scholar
• Achille, A. et al. Chromosome 7q allelic losses in pancreatic carcinoma. Cancer Res. 56, 3808–3813 (1996).
  CAS PubMed Google Scholar
• Shridhar, V. et al. Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas. Oncogene 15, 2727–2733 (1997).
  Article CAS Google Scholar
• Neuman, W.L. et al. Chromosomal loss and deletion are the most common mechanisms for loss of heterozygosity from chromosomes 5 and 7 in malignant myeloid disorders. Blood 79, 1501–1510 (1992).
  CAS PubMed Google Scholar
• Ogata, T. et al. Genetic complementation of the immortal phenotype in group D cell lines by introduction of chromosome 7. Jpn. J. Cancer Res. 86, 35–40 (1995).
  Article CAS Google Scholar
• Ogata, T. et al. Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol. Cell. Biol. 13, 6036–6043 (1993).
  Article CAS Google Scholar
• Zenklusen, J.C., Oshimura, M., Barrett, J.C. & Conti, C.J. Inhibition of tumorigenicity of a murine squamous cell carcinoma (SCC) cell line by a putative tumor suppressor gene on human chromosome 7. Oncogene 9, 2817–2825 (1994).
  CAS PubMed Google Scholar
• Zenklusen, J.C., Hodges, L.C., LaCava, M., Green, E.D. & Conti, C.J. Definitive functional evidence for a tumor suppressor gene on human chromosome 7q31.1 neighboring the Fra7G site. Oncogene 19, 1729–1733 (2000).
  Article CAS Google Scholar
• Matsuda, T. et al. Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma. Oncogene 15, 2773–2781 (1997).
  Article CAS Google Scholar
• Zenklusen, J.C., Weintraub, L.A. & Green, E.D. Construction of a high-resolution physical map of the approximate 1-Mb region of human chromosome 7q31.1–q31.2 harboring a putative tumor suppressor gene. Neoplasia 1, 16–22 (1999).
  Article CAS Google Scholar
• Deloukas, P. et al. A physical map of 30,000 human genes. Science 282, 744–746 (1998).
  Article CAS Google Scholar
• Bouffard, G.G. et al. A physical map of human chromosome 7: an integrated YAC contig map with average STS spacing of 79 kb. Genome Res. 7, 673–692 (1997).
  Article CAS Google Scholar
• Burge, C.B. & Karlin, S. Finding the genes in genomic DNA. Curr. Opin. Struct. Biol. 8, 346–354 (1998).
  Article CAS Google Scholar
• Xu, Y., Einstein, J.R., Mural, R.J., Shah, M. & Uberbacher, E.C. An improved system for exon recognition and gene modeling in human DNA sequences. Proc. Int. Conf. Intell. Syst. Mol. Biol. 2, 376–384 (1994).
  CAS PubMed Google Scholar
• Zhang, J. & Madden, T. PowerBLAST: a new network BLAST application for interactive or automated sequence analysis annotation. Genome Res. 7, 649–656 (1997).
  Article CAS Google Scholar
• Seibert, F., Loo, T., Clarke, D. & Riordan, J. Cystic fibrosis: channel, catalytic, and folding properties of the CFTR protein. J. Bioenerg. Biomembr. 29, 429–442 (1997).
  Article CAS Google Scholar
• Vande Woude, G. et al. Met-HGF/SF: tumorigenesis, invasion, and metastasis. Ciba Found. Symp. 212, 119–132 (1997).
  CAS PubMed Google Scholar
• Dale, T. et al. Compartment switching of WNT-2 expression in human breast tumors. Cancer Res. 56, 4320–4323 (1996).
  CAS PubMed Google Scholar
• Chang, W.J. et al. Purification and characterization of smooth muscle cell caveolae. J. Cell Biol. 126, 127–138 (1994).
  Article CAS Google Scholar
• Hurlstone, A.F. et al. Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Oncogene 18, 1881–1890 (1999).
  Article CAS Google Scholar
• Caldwell, J.E., Heiss, S.G., Mermall, V. & Cooper, J.A. Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin. Biochemistry 28, 8506–8514 (1989).
  Article CAS Google Scholar
• Frohman, M.A., Dush, M.K. & Martin, G.R. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85, 8998–9002 (1988).
  Article CAS Google Scholar
• Tuvia, S., Buhusi, M., Davis, L., Reedy, M. & Bennett, V. Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. J. Cell Biol. 147, 995–1008 (1999).
  Article CAS Google Scholar
• Vincent, J.B. et al. Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. Am. J. Hum. Genet. 67, 510–514 (2000).
  Article CAS Google Scholar
• Corpet, F., Servant, F., Gouzy, J. & Kahn, D. ProDom and ProDom-CG: tools for protein domain analysis and whole genome comparisons. Nucleic Acids Res. 28, 267–269 (2000).
  Article CAS Google Scholar
• Kaighn, M.E., Lechner, J.F., Narayan, K.S. & Jones, L.W. Prostate carcinoma: tissue culture cell lines. Natl. Cancer Inst. Monogr. 49, 17–21 (1978).
  Google Scholar
• Sprenger, C.C., Damon, S.E., Hwa, V., Rosenfeld, R.G. & Plymate, S.R. Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor suppressor protein for prostate cancer. Cancer Res. 59, 2370–2375 (1999).
  CAS PubMed Google Scholar
• Trovato, M. et al. Loss of heterozygosity of the long arm of chromosome 7 in follicular and anaplastic thyroid cancer, but not in papillary thyroid cancer. J. Clin. Endocrinol. Metab. 84, 3235–3240 (1999).
  Article CAS Google Scholar
• Koike, M., Tasaka, T., Spira, S., Tsuruoka, N. & Koeffler, H.P. Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33–34 (D7S498, D7S505). Leuk. Res. 23, 307–310 (1999).
  Article CAS Google Scholar
• Bieche, I., Khodja, A., Driouch, K. & Lidereau, R. Genetic alteration mapping on chromosome 7 in primary breast cancer. Clin. Cancer Res. 3, 1009–1016 (1997).
  CAS PubMed Google Scholar
• Lin, J.C. et al. Detailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of MET. Oncogene 13, 2001–2008 (1996).
  CAS PubMed Google Scholar
• Black, D.M. Characterization of a multi-tissue tumour suppressor and senescence gene. Br. J. Cancer 80 (Suppl. 1), 42–45 (1999).
  CAS PubMed Google Scholar
• Tatarelli, C., Linnenbach, A., Mimori, K. & Croce, C.M. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. Genomics 68, 1–12 (2000).
  Article CAS Google Scholar
• Michaels, J.E., Schimmel, P., Shiba, K. & Miller, W.T. Dominant negative inhibition by fragments of a monomeric enzyme. Proc. Natl. Acad. Sci. USA 93, 14452–14455 (1996).
  Article CAS Google Scholar
• El-Naggar, A.K. et al. Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma. Am. J. Pathol. 151, 1767–1774 (1997).
  CAS PubMed PubMed Central Google Scholar
• Myohanen, S.K., Baylin, S.B. & Herman, J.G. Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res. 58, 591–593 (1998).
  CAS Google Scholar
• Huang, H. et al. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. Genes Chromosomes Cancer 24, 48–55 (1999).
  Article CAS Google Scholar
• Moore, D.D. Preparation and analysis of DNA. in Current Protocols in Molecular Biology (eds. Ausubel, F.M. et al.) 2.1.0–2.3.8 (Greene Publishing and John Wiley Sons, New York, 1992).
  Google Scholar