Telomere dysfunction and evolution of intestinal carcinoma in mice and humans (original) (raw)
Kim, N.W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science266, 2011–2005 (1994). ArticleCAS Google Scholar
Hahn, W.C. et al. Creation of human tumour cells with defined genetic elements. Nature400, 464–468 (1999). ArticleCAS Google Scholar
Greenberg, R.A. et al. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell97, 515–525 (1999). ArticleCAS Google Scholar
Gonzalez-Suarez, E., Samper, E., Flores, J.M. & Blasco, M.A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nature Genet . 26, 114–117 (2000). ArticleCAS Google Scholar
Engelhardt, M., Drullinsky, P., Guillem, J. & Moore, MA. Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer. Clin. Cancer Res . 3, 1931–1941 (1997). CASPubMed Google Scholar
Tang, R., Cheng, A.J., Wang, J.Y. & Wang, T.C. Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis. Cancer Res.58, 4052–4054 (1998). CASPubMed Google Scholar
Chadeneau, C., Hay, K., Hirte, H.W., Gallinger, S. & Bacchetti, S. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res.55, 2533–2536 (1995). CASPubMed Google Scholar
Artandi, S. et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature406, 641–645 (2000). ArticleCAS Google Scholar
Moser, A.R., Pitot, H.C. & Dove, W.F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science247, 322–324 (1990). ArticleCAS Google Scholar
Su, L.K. et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science256, 668–670 (1992). ArticleCAS Google Scholar
Young, J. et al. Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum. Mutat.2, 351–354 (1993). ArticleCAS Google Scholar
Okamoto, M. et al. Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli. Nature331, 273–277 (1988). ArticleCAS Google Scholar
Ried, T. et al. Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosom. Cancer15, 234–245 (1996). ArticleCAS Google Scholar
Meijer, G.A. et al. Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation. J. Clin. Pathol.51, 901–909 (1998). ArticleCAS Google Scholar
Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instabilities in human cancers. Nature396, 643–649 (1998). ArticleCAS Google Scholar
Dietrich, W.F. et al. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell75, 631–639 (1993). ArticleCAS Google Scholar
Halberg, R.B. et al. Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc. Natl. Acad. Sci. USA97, 3461–3466 (2000). ArticleCAS Google Scholar
Blasco, M.A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell91, 25–34 (1997). ArticleCAS Google Scholar
Herrera, E. et al. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J.18, 2950–2960 (1999). ArticleCAS Google Scholar
Lee, H.W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature392, 569–574 (1998). ArticleCAS Google Scholar
Rudolph, K.L. et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell96, 701–712 (1999). ArticleCAS Google Scholar
Luongo, C. & Dove, W.F. Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse. Genes Chromosom. Cancer17, 194–198 (1996). ArticleCAS Google Scholar
Luo, G. et al. Cancer predisposition caused by elevated mitotic recombination in bloom mice. Nature Genet.26, 424–429 (2000). ArticleCAS Google Scholar
van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell92, 401–413 (1998). ArticleCAS Google Scholar
Kirk, K.E., Harmon, B.P., Reichardt, I.K., Sedat, J.W. & Blackburn, E.H. Block in anaphase chromosome separation caused by a telomerase template mutation. Science275, 1478–1481 (1997). ArticleCAS Google Scholar
Rudolph, K.L., Chang, S., Millard, M., Schreiber-Agus, N. & DePinho, R.A. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science287, 1253–1258 (2000). ArticleCAS Google Scholar
Chin, L. et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell97, 527–538 (1999). ArticleCAS Google Scholar
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. & de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science283, 1321–1325 (1999). ArticleCAS Google Scholar
Hastie, N.D. et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature346, 866–868 (1990). ArticleCAS Google Scholar