TCR avidity: it's not how strong you make it, it's how you make it strong (original) (raw)

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• Published: August 2001

Nature Immunology volume 2, pages 669–670 (2001)Cite this article

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Unlike the BCR, the TCR cannot undergo affinity maturation. However, T cells respond with greater sensitivity to antigen during an immune response. New evidence suggests T cells undergo avidity maturation to enhance T cell responsiveness in the absence of changes in intrinsic affinity.

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Figure 1: Model for TCR and coreceptor rearrangements in the progression from naïve to activated T cells.

Bob Crimi

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1. Molecular Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, 10 Center Drive, Bethesda, 20892-1892, MD, USA
   David H. Margulies

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Margulies, D. TCR avidity: it's not how strong you make it, it's how you make it strong.Nat Immunol 2, 669–670 (2001). https://doi.org/10.1038/90601

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• Issue Date: August 2001
• DOI: https://doi.org/10.1038/90601

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