Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis (original) (raw)

• Kelly KJ . Acute renal failure: much more than a kidney disease. Semin Nephrol 2006; 26: 105–13.
  Article CAS Google Scholar
• Levin A, Djurdjev O, Barrett B, Burgess E, Carlisle E, Ethier J, et al. Cardiovascular disease in patients with chronic kidney disease: Getting to the heart of the matter. Am J Kidney Dis 2001; 38: 1398–407.
  Article CAS Google Scholar
• Hruska KA, Korkor A, Martin K, Slatopolsky E . Peripheral metabolism of intact parathyroid hormone. Role of liver and kidney and the effect of chronic renal failure. J Clin Invest 1981; 67: 885–92.
  Article CAS Google Scholar
• Nair KS . Amino acid and protein metabolism in chronic renal failure. J Renal Nutr 2005; 15: 28–33.
  Article Google Scholar
• Zhao YY, Feng YL, Bai X, Tan XJ, Lin RC, Mei Q . Ultra performance liquid chromatography-based metabonomic study of therapeutic effect of the surface layer of Poria cocos on adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism. PLoS One 2013; 8: e59617.
  Article CAS Google Scholar
• Zhao YY, Lei P, Chen DQ, Feng YL, Bai X . Renal metabolic profiling of early renal injury and renoprotective effects of Poria cocos epidermis using UPLC Q-TOF/HSMS/MSE. J Pharm Biomed Anal 2013; 81–82: 202–9.
  PubMed Google Scholar
• Zhao YY, Shen XF, Cheng XL, Wei F, Bai X, Lin RC . Urinary metabonomics study on the protective effects of ergosta-4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MSE data collection technique. Process Biochem 2012; 47: 1980–87.
  Article CAS Google Scholar
• Zhao YY, Feng YL, Du X, Xi ZH, Cheng XL, Wei F . Diuretic activity of the ethanol and aqueous extracts of the surface layer of Poria cocos in rat. J Ethnopharmacol 2012; 144: 775–8.
  Article Google Scholar
• Zhong F, Liu X, Zhou Q, Hao X, Lu Y, Guo S, et al. 1H NMR spectroscopy analysis of metabolites in the kidneys provides new insight into pathophysiological mechanisms: applications for treatment with Cordyceps sinensis. Nephrol Dial Transplant 2012; 27: 556–65.
  Article Google Scholar
• Li FH, Liu P, Xiong WG, Xu GF . Effects of Cordyceps sinensis on dimethylnitrosamine-induced liver fibrosis in rats. Zhong Xi Yi Jie He Xue Bao 2006; 4: 514–7.
  Article Google Scholar
• Yan XF, Zhang ZM, Yao HY, Guan Y, Zhu JP, Zhang LH, et al. Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors. Phytother Res 2013; 27: 1597–604.
  Article Google Scholar
• Zhang Z, Xia SS . _Cordyceps sinensis_-I as an immunosuppressant in heterotopic heart allograft model in rats. J Tongji Med Univ 1990; 10: 100–3.
  Article CAS Google Scholar
• Huang Q, Tan Y, Yin P, Ye G, Gao P, Lu X, et al. Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. Cancer Res 2013; 73: 4992–5002.
  Article CAS Google Scholar
• Maekawa K, Hirayama A, Iwata Y, Tajima Y, Nishimaki-Mogami T, Sugawara S, et al. Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy. J Mol Cell Cardiol 2013; 59: 76–85.
  Article CAS Google Scholar
• Zhao YY . Metabolomics in chronic kidney disease. Clin Chim Acta 2013; 422: 59–69.
  Article CAS Google Scholar
• Zhao YY, Cheng XL, Wei F, Bai X, Tan XJ, Lin RC, et al. Intrarenal metabolomic investigation of chronic kidney disease and its TGF-beta1 mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MSE. J Proteome Res 2013; 12: 692–703.
  Article CAS Google Scholar
• Mutsaers HA, Engelke UF, Wilmer MJ, Wetzels JF, Wevers RA, van den Heuvel LP, et al. Optimized metabolomic approach to identify uremic solutes in plasma of stage 3–4 chronic kidney disease patients. PLoS One 2013; 8: e71199.
  Article CAS Google Scholar
• Qi S, Ouyang X, Wang L, Peng W, Wen J, Dai Y . A pilot metabolic profiling study in serum of patients with chronic kidney disease based on (1) H-NMR-spectroscopy. Clin Transl Sci 2012; 5: 379–85.
  Article CAS Google Scholar
• Zhao YY, Liu J, Cheng XL, Bai X, Lin RC . Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. Clin Chim Acta 2012; 413: 642–9.
  Article CAS Google Scholar
• Creek DJ, Barrett MP . Determination of antiprotozoal drug mechanisms by metabolomics approaches. Parasitology 2014; 141: 83–92.
  Article Google Scholar
• Beyoglu D, Idle JR . Metabolomics and its potential in drug development. Biochem Pharmacol 2013; 85: 12–20.
  Article CAS Google Scholar
• Gu Y, Zhang Y, Shi X, Li X, Hong J, Chen J, et al. Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta 2010; 81: 766–72.
  Article CAS Google Scholar
• Zhao X, Zhang Y, Meng X, Yin P, Deng C, Chen J, et al. Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: a urinary metabonomics study based on liquid chromatography-mass spectrometry (Research Support, Non-US Gov't). J chromatogr B 2008; 873: 151–8.
  Article CAS Google Scholar
• Peng SL, Liu XW, Zhang ZR . Investigation of therapeutic mechanism of Weiweifang on experimental gastric ulcer in rats viewing from metabonomics. Zhongguo Zhong Xi Yi Jie He Za Zhi 2010; 30: 1073–7.
  CAS PubMed Google Scholar
• Lian F, Zhao B, Lu XM . Effect of er'zhi tiangui granule on metabonomics and level of Ca2+ in follicle fluid in patients after in vitro fertilization and embryo transfer. Zhongguo Zhong Xi Yi Jie He Za Zhi 2010; 30: 22–5.
  PubMed Google Scholar
• Liang X, Chen X, Liang Q, Zhang H, Hu P . Wang Y, et al. Metabonomic study of Chinese medicine Shuanglong Formula as an effective treatment for myocardial infarction in rats. J Proteome Res 2011; 10: 790–9.
  Article CAS Google Scholar
• Manotham K, Eiam-Ong S, Wannakrairot P, Praditpornsilpa K, Chusil S, Tungsanga K . Citrate attenuates tubulointerstitial fibrosis in 5/6 nephrectomized rats by decreasing transforming growth factor-beta1. J Med Assoc Thai 2006; 89 Suppl 2: S168–77.
  PubMed Google Scholar
• Ghosh SS, Massey HD, Krieg R, Fazelbhoy ZA, Ghosh S, Sica DA, et al. Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation. Am J Physiol Renal Physiol 2009; 296: F1146–57.
  Article CAS Google Scholar
• Kasiske BL, O'Donnell MP, Garvis WJ, Keane WF . Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 5/6 nephrectomy model of chronic renal failure. Circ Res 1988; 62: 367–74.
  Article CAS Google Scholar
• Waldherr R, Gretz N . Natural course of the development of histological lesions after 5/6 nephrectomy. Contrib Nephrol 1988; 60: 64–72.
  Article CAS Google Scholar
• Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, et al. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc 2007; 2: 2692–703.
  Article CAS Google Scholar
• Weljie AM, Dowlatabadi R, Miller BJ, Vogel HJ, Jirik FR . An inflammatory arthritis-associated metabolite biomarker pattern revealed by 1H NMR spectroscopy. J Proteome Res 2007; 6: 3456–64.
  Article CAS Google Scholar
• Asiago VM, Alvarado LZ, Shanaiah N, Gowda GA, Owusu-Sarfo K, Ballas RA, et al. Early detection of recurrent breast cancer using metabolite profiling. Cancer Res 2010; 70: 8309–18.
  Article CAS Google Scholar
• Cloarec O, Dumas ME, Trygg J, Craig A, Barton RH, Lindon JC, et al. Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies. Anal Chem 2005; 77: 517–26.
  Article CAS Google Scholar
• Carrola J, Rocha CM, Barros AS, Gil AM, Goodfellow BJ, Carreira IM, et al. Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine. J Proteome Res 2011; 10: 221–30.
  Article CAS Google Scholar
• Ding L, Hao F, Shi Z, Wang Y, Zhang H, Tang H, et al. Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies. J Proteome Res 2009; 8: 2882–91.
  Article CAS Google Scholar
• Fan TWM, Lane AN . Structure-based profiling of metabolites and isotopomers by NMR. Prog Nucl Mag Res Sp 2008; 52: 69–117.
  Article CAS Google Scholar
• Tang HR, Wang YL, Nicholson JK, Lindon JC . Use of relaxation-edited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma. Anal Biochem 2004; 325: 260–72.
  Article CAS Google Scholar
• Lindgren F, Hansen B, Karcher W, Sjostrom M, Eriksson L . Model validation by permutation tests: Applications to variable selection. J Chemometr 1996; 10: 521–32.
  Article CAS Google Scholar
• Westerhuis JA, Hoefsloot HCJ, Smit S, Vis DJ, Smilde AK, van Velzen EJJ, et al. Assessment of PLSDA cross validation. Metabolomics 2008; 4: 81–9.
  Article CAS Google Scholar
• Okuda S, Yamada T, Hamajima M, Itoh M, Katayama T, Bork P, et al. KEGG Atlas mapping for global analysis of metabolic pathways (Research Support, Non-U.S. Gov't). Nucleic Acids Res 2008; 36 (Web Server issue): W423–6.
  Article CAS Google Scholar
• Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, et al. HMDB: the human metabolome database. Nucleic Acids Res 2007; 35: D521–D26.
  Article CAS Google Scholar
• Mytilineou C, Kramer BC, Yabut JA . Glutathione depletion and oxidative stress. Parkinsonism Relat Disord 2002; 8: 385–7.
  Article Google Scholar
• Shaw S, Rubin KP, Lieber CS . Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease. Evidence of lipid peroxidation. Dig Dis Sci 1983; 28: 585–9.
  Article CAS Google Scholar
• Wang X, Kanel GC, DeLeve LD . Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat. Hepatology 2000; 31: 428–34.
  Article CAS Google Scholar
• Barbaro G, Di Lorenzo G, Soldini M, Parrotto S, Bellomo G, Belloni G, et al. Hepatic glutathione deficiency in chronic hepatitis C: quantitative evaluation in patients who are HIV positive and HIV negative and correlations with plasmatic and lymphocytic concentrations and with the activity of the liver disease. Am J Gastroenterol 1996; 91: 2569–73.
  CAS PubMed Google Scholar
• Summer KH, Eisenburg J . Low content of hepatic reduced glutathione in patients with Wilson's disease. Biochem Med 1985; 34: 107–11.
  Article CAS Google Scholar
• Lanza IR, Zhang SC, Ward LE, Karakelides H, Raftery D, Nair KS . Quantitative metabolomics by H-1-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PloS One 2010; 5: e10538.
  Article Google Scholar
• Obrosova IG, Fathallah L, Stevens MJ . Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. Exp Neurol 2001; 172: 211–9.
  Article CAS Google Scholar
• Das J, Ghosh J, Manna P, Sil PC . Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radical Res 2010; 44: 340–55.
  Article CAS Google Scholar
• Rashid K, Das J, Sil PC . Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats. Food Chem Toxicol 2013; 51: 317–29.
  Article CAS Google Scholar
• Zinellu A, Sotgia S, Loriga G, Deiana L, Satta AE, Carru C . Oxidative stress improvement is associated with increased levels of taurine in CKD patients undergoing lipid-lowering therapy. Amino Acids 2012; 43: 1499–507.
  Article CAS Google Scholar
• Yu HM, Wang BS, Huang SC, Duh PD . Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage. J Agr Food Chem 2006; 54: 3132–8.
  Article CAS Google Scholar
• Wisnowski JL, Bluml S, Paquette L, Zelinski E, Nelson MD Jr, Painter MJ, et al. Altered glutamatergic metabolism associated with punctate white matter lesions in preterm infants. PLoS One 2013; 8: e56880.
  Article CAS Google Scholar
• Poole RK, Haddock BA . Energy-linked reduction of nicotinamide — adenine dinucleotide in membranes derived from normal and various respiratory-deficient mutant strains of Escherichia coli K12. Biochem J 1974; 144: 77–85.
  Article CAS Google Scholar
• Serviddio G, Giudetti AM, Bellanti F, Priore P, Rollo T, Tamborra R, et al. Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet. PLoS One 2011; 6: e24084.
  Article CAS Google Scholar
• Lemire J, Mailloux R, Darwich R, Auger C, Appanna VD . The disruption of _L_-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells. Toxicol Lett 2011; 203: 219–26.
  Article CAS Google Scholar