Polyclonal origin of mouse skin papillomas (original) (raw)

Abstract

We show that, from the earliest morphologically recognisable stages of development, mouse skin papillomas induced by a chemical initiation-promotion regime are polyclonal. We have demonstrated polyclonality directly by immunohistochemical staining of the mosaic cell populations in embryo aggregation chimaeras, a method which removes some of the uncertainties of previous conclusions based on analysis using electrophoretic polymorphisms. The findings may imply that initiation within a single cell and promotion of its clonal descendents is not a sufficient explanation for the origin of these tumours and that interaction between cells of more than one clone is involved.

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Authors and Affiliations

  1. Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
    DJ Winton

Authors

  1. DJ Winton
  2. MA Blount
  3. BAJ Ponder

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Winton, D., Blount, M. & Ponder, B. Polyclonal origin of mouse skin papillomas.Br J Cancer 60, 59–63 (1989). https://doi.org/10.1038/bjc.1989.220

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