Tumour-associated hypoglycaemia in a murine cachexia model (original) (raw)

British Journal of Cancer volume 66, pages 815–820 (1992)Cite this article

Abstract

Animals bearing a cachexia-inducing tumour, the MAC16 adenocarcinoma, showed a progressive decrease in blood glucose levels with increasing weight loss, while animals bearing a histologically similar tumour, the MAC13 adenocarcinoma, showed no change in either body weight or blood glucose levels with growth of the tumour. The effect of the MAC16 tumour on blood glucose levels appeared to be unrelated to food intake, glucose consumption by the tumour, or to the production of increased levels of IGF-I and IGF-II mRNA by the tumour cells. The relationship between the induction of cachexia and alteration in blood glucose levels remains unknown.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 24 print issues and online access

$259.00 per year

only $10.79 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

Author information

Authors and Affiliations

  1. CRC Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
    TM McDevitt

Authors

  1. TM McDevitt
    You can also search for this author inPubMed Google Scholar
  2. MJ Tisdale
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

McDevitt, T., Tisdale, M. Tumour-associated hypoglycaemia in a murine cachexia model.Br J Cancer 66, 815–820 (1992). https://doi.org/10.1038/bjc.1992.366

Download citation

This article is cited by