Tumour-associated hypoglycaemia in a murine cachexia model (original) (raw)
- Experimental Oncology
- Published: 01 November 1992
British Journal of Cancer volume 66, pages 815–820 (1992)Cite this article
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Abstract
Animals bearing a cachexia-inducing tumour, the MAC16 adenocarcinoma, showed a progressive decrease in blood glucose levels with increasing weight loss, while animals bearing a histologically similar tumour, the MAC13 adenocarcinoma, showed no change in either body weight or blood glucose levels with growth of the tumour. The effect of the MAC16 tumour on blood glucose levels appeared to be unrelated to food intake, glucose consumption by the tumour, or to the production of increased levels of IGF-I and IGF-II mRNA by the tumour cells. The relationship between the induction of cachexia and alteration in blood glucose levels remains unknown.
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Authors and Affiliations
- CRC Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK
TM McDevitt
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- TM McDevitt
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McDevitt, T., Tisdale, M. Tumour-associated hypoglycaemia in a murine cachexia model.Br J Cancer 66, 815–820 (1992). https://doi.org/10.1038/bjc.1992.366
- Issue Date: 01 November 1992
- DOI: https://doi.org/10.1038/bjc.1992.366