Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro (original) (raw)

Abstract

The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body weight i.p. thrice weekly for 4-6 weeks. Tumour growth was significantly inhibited in treated animals compared with controls in the absence of hypercalcaemia. These findings may have therapeutic implications in pancreatic cancer.

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Authors and Affiliations

1. Division of Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, London, UK
   KW Colston

Authors

1. KW Colston
2. SY James
3. EA Ofori-Kuragu
4. L Binderup
5. AG Grant

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Colston, K., James, S., Ofori-Kuragu, E. et al. Vitamin D receptors and anti-proliferative effects of vitamin D derivatives in human pancreatic carcinoma cells in vivo and in vitro.Br J Cancer 76, 1017–1020 (1997). https://doi.org/10.1038/bjc.1997.501

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• Issue date: 01 October 1997
• DOI: https://doi.org/10.1038/bjc.1997.501