Allelotype analysis of adenocarcinoma of the gastric cardia (original) (raw)

• Experimental Oncology
• Published: 01 December 1997

British Journal of Cancer volume 76, pages 1455–1465 (1997)Cite this article

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Abstract

To identify chromosomal loci involved in the development of proximal gastric adenocarcinoma, this study delineated the pattern of allelic imbalance in a series of 38 adenocarcinomas arising in the gastric cardia. A total of 137 microsatellite markers covering all autosomal arms, excluding acrocentric arms, were analysed. A mean of 35 out of a total of 39 chromosomal arms studied were informative for each patient. The tumour group demonstrated a high level of allelic imbalance, with an observed median fractional allelic imbalance of 0.47 for the 29 intestinal-type adenocarcinomas and 0.54 for the nine diffuse-type adenocarcinomas. Allelic imbalance was detected in >50% of informative cases in both histological subtypes on a number of chromosomal arms. In the intestinal subtype, these included, 3p (61%), 4q (71%), 5q (59%), 8p (60%), 9p (65%), 9q (83%), 12q (52%), 13q (52%), 17p (78%) and 18q (70%). A higher incidence of allelic imbalance was detected on chromosome 16q in tumours of the diffuse type relative to those of the intestinal type. A more detailed mapping on chromosomes 4q and 6q identified a number of cases with subchromosomal breakpoints. In conclusion, this analysis has indicated regions of the genome potentially involved in the development of proximal gastric carcinomas.

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Authors and Affiliations

1. Department of Medical Genetics, The Queen's University of Belfast, Belfast City Hospital, UK
   CM Gleeson

Authors

1. CM Gleeson
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2. JM Sloan
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3. JA McGuigan
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4. AJ Ritchie
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5. JL Weber
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6. SE Russell
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Gleeson, C., Sloan, J., McGuigan, J. et al. Allelotype analysis of adenocarcinoma of the gastric cardia.Br J Cancer 76, 1455–1465 (1997). https://doi.org/10.1038/bjc.1997.578

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• Issue Date: 01 December 1997
• DOI: https://doi.org/10.1038/bjc.1997.578

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