A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2 (original) (raw)

Abbreviations

CNS:

central nervous sytem

FISH:

fluorescent in situ hybridization

LUHMES:

Lund Human Mesencephalic neurons

IMSS:

inner membrane sorting signal

MLS:

mitochondrial localization signal

MOMP:

mitochondrial outer membrane permeabilization. NCI, National Cancer Institute

NLS:

nuclear localization signal

TEM:

transmission electron microscopy

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Acknowledgements

EH is supported by a fellowship from the Ligue Nationale contre le Cancer. GK is supported by grants from European Union (projects Apo-Sys, ChemoRes, Death-Train), La Ligue Nationale Contre le Cancer (équipe labélisée), Institut National du Cancer (INCa), Agence Nationale de Recherche (ANR). FC is supported by grants from the Telethon Foundation, AIRC and the Italian Ministry of University and Research. PB and PR are supported by grants from European Union (project EumitoCombat), Leducq foundation. GH is supported by the German National Genome Research Network (01GS08136-4). We acknowledge the DTP at NCI for providing RNA samples for NCI60 panel of cancer cell lines; Marcel Leist, University of Konstanz, Germany for providing the LUHMES cells; Abdelali Jalil, Didier Métivier and Fulvio Florenzano for help with flow cytometry and confocal microscopy; Eric Jacquet and Imagif (CNRS) Platform for quantitative RT-PCR analyses.

Author information

Author notes

1. G Kroemer and N Modjtahedi: These authors share co-senior authorship.

Authors and Affiliations

1. INSERM U848, Villejuif, France
   E Hangen, F Caffin, S Lachkar, J-L Perfettini, J M Vicencio, G Kroemer & N Modjtahedi
2. Institut Gustave Roussy, Villejuif, France
   E Hangen, P Dessen, F Caffin, S Lachkar, J-L Perfettini, V Lazar, J Benard, J M Vicencio, G Kroemer & N Modjtahedi
3. University Paris 11, Orsay, France
   E Hangen, P Dessen, F Caffin, S Lachkar, J-L Perfettini, V Lazar, J Benard, J M Vicencio, G Kroemer & N Modjtahedi
4. Department of Biology, Dulbecco Telethon Institute, University of Rome, ‘Tor Vergata’, Rome, Italy
   D De Zio, M Bordi & F Cecconi
5. Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome, Italy
   D De Zio, M Bordi & F Cecconi
6. Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
   C Zhu & K Blomgren
7. CNRS FRE2939, Vilejuif, France
   P Dessen
8. Functional Genomic Unit, Villejuif, France
   V Lazar
9. CNRS UMR8126, Villejuif, France
   J Benard
10. National Institute for Infectious Diseases, ‘Lazzaro Spallanzani’, Rome, Italy
    G M Fimia & M Piacentini
11. Laboratoire ‘Réplication de l′ADN et Ultrastructure du Noyau’ CNRS-Institut André Lwoff, Villejuif, 94801, France
    F Harper & G Pierron
12. INSERM U676, Paris, France
    P Bénit & P Rustin
13. Hôpital Robert Debré, Paris, France
    P Bénit & P Rustin
14. University René Diderot, Paris, France
    P Bénit & P Rustin
15. Experimental Neurology, Philipps University, Marburg, Germany
    A de Andrade & G Höglinger
16. Department of Pharmacy, Institute for Pharmacology and Toxicology, Philipps-University Marburg, Marburg, Germany
    C Culmsee
17. Department of Pediatric Oncology, Queen Silvia Children's Hospital, Gothenburg, Sweden
    K Blomgren

Authors

1. E Hangen
2. D De Zio
3. M Bordi
4. C Zhu
5. P Dessen
6. F Caffin
7. S Lachkar
8. J-L Perfettini
9. V Lazar
10. J Benard
11. G M Fimia
12. M Piacentini
13. F Harper
14. G Pierron
15. J M Vicencio
16. P Bénit
17. A de Andrade
18. G Höglinger
19. C Culmsee
20. P Rustin
21. K Blomgren
22. F Cecconi
23. G Kroemer
24. N Modjtahedi

Corresponding authors

Correspondence toG Kroemer or N Modjtahedi.

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Competing interests

The authors declare no conflict of interest.

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Edited by JC Martinou

Supplementary Information accompanies the paper on Cell Death and Differentiation website

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Hangen, E., De Zio, D., Bordi, M. et al. A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2.Cell Death Differ 17, 1155–1166 (2010). https://doi.org/10.1038/cdd.2009.211

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• Received: 01 July 2009
• Revised: 11 November 2009
• Accepted: 01 December 2009
• Published: 29 January 2010
• Issue date: July 2010
• DOI: https://doi.org/10.1038/cdd.2009.211

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