Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation (original) (raw)

• Kroemer G, Levine B . Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008; 9: 1004–1010.
  Article CAS Google Scholar
• Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61: 439–444.
  CAS Google Scholar
• Espert L, Denizot M, Grimaldi M, Robert-Hebmann V, Gay B, Varbanov M et al. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest 2006; 116: 2161–2172.
  Article CAS Google Scholar
• Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25: 1025–1040.
  Article CAS Google Scholar
• Hamacher-Brady A, Brady NR, Gottlieb RA . Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 2006; 281: 29776–29787.
  Article CAS Google Scholar
• Ding WX, Ni HM, Gao W, Hou YF, Melan MA, Chen X et al. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem 2007; 282: 4702–4710.
  Article CAS Google Scholar
• Czaja MJ . Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology 2011; 140: 1895–1908.
  Article Google Scholar
• Schattenberg JM, Czaja MJ . TNF and TNF receptors In: Dufour JF, Clavien P-A, (eds). Signaling Pathways in Liver Diseases 2nd edn. Springer-Verlag: Berlin, 2010 pp 161–179.
  Chapter Google Scholar
• Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A et al. NF-κB inactivation converts a hepatocyte cell line TNF-α response from proliferation to apoptosis. Am J Physiol 1998; 275: C1058–C1066.
  Article CAS Google Scholar
• Liu H, Lo CR, Czaja MJ . NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. Hepatology 2002; 35: 772–778.
  Article CAS Google Scholar
• Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA . Differential requirement for c-Jun NH2-terminal kinase in TNFα- and Fas-mediated apoptosis in hepatocytes. FASEB J 2004; 18: 720–722.
  Article CAS Google Scholar
• Kim I, Lemasters JJ . Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal 2011; 14: 1919–1928.
  Article CAS Google Scholar
• Nowak M, Gaines GC, Rosenberg J, Minter R, Bahjat FR, Rectenwald J et al. LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-α and the TNF-p55 receptor. Am J Physiol Regul Integr Comp Physiol 2000; 278: R1202–R1209.
  Article CAS Google Scholar
• Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032–1036.
  Article CAS Google Scholar
• Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169: 425–434.
  Article CAS Google Scholar
• Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M et al. Autophagy regulates lipid metabolism. Nature 2009; 458: 1131–1135.
  Article CAS Google Scholar
• Kuhn R, Schwenk F, Aguet M, Rajewsky K . Inducible gene targeting in mice. Science 1995; 269: 1427–1429.
  Article CAS Google Scholar
• Schuler M, Dierich A, Chambon P, Metzger D . Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis 2004; 39: 167–172.
  Article CAS Google Scholar
• Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 1999; 400: 886–891.
  Article CAS Google Scholar
• Wang Y, Singh R, Xiang Y, Czaja MJ . Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress. Hepatology 2010; 52: 266–277.
  Article CAS Google Scholar
• Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIPL turnover. Cell 2006; 124: 601–613.
  Article CAS Google Scholar
• Wang Y, Singh R, Lefkowitch JH, Rigoli RM, Czaja MJ . Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 2006; 281: 15258–15267.
  Article CAS Google Scholar
• Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner DA . Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology 2009; 136: 1423–1434.
  Article CAS Google Scholar
• Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS . Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Hepatology 2011; 53: 2053–2062.
  Article CAS Google Scholar
• Haspel J, Shaik RS, Ifedigbo E, Nakahira K, Dolinay T, Englert JA et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy 2011; 7: 629–642.
  Article CAS Google Scholar
• Laplante M, Sabatini DM . mTOR signaling in growth control and disease. Cell 2012; 149: 274–293.
  Article CAS Google Scholar
• Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011; 331: 456–461.
  Article CAS Google Scholar
• Yang L, Li P, Fu S, Calay ES, Hotamisligil GS . Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 2010; 11: 467–478.
  Article CAS Google Scholar
• Wang JH, Ahn IS, Fischer TD, Byeon JI, Dunn WA, Behrns KE et al. Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology 2011; 141: 2188–2199.
  Article CAS Google Scholar
• Kovacs JR, Li C, Yang Q, Li G, Garcia IG, Ju S et al. Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ 2012; 19: 144–152.
  Article CAS Google Scholar
• Young M, Takahashi Y, Khan O, Park S, Hori T, Yun J et al. Autophagosomal membrane serves as a platform for an intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J Biol Chem 2012; 287: 12455–12468.
  Article CAS Google Scholar
• Laussmann MA, Passante E, Dussmann H, Rauen JA, Wurstle ML, Delgado ME et al. Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8. Cell Death Differ 2011; 18: 1584–1597.
  Article CAS Google Scholar
• Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN et al. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005; 280: 20722–20729.
  Article CAS Google Scholar
• Thorburn J, Moore F, Rao A, Barclay WW, Thomas LR, Grant KW et al. Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol Biol Cell 2005; 16: 1189–1199.
  Article CAS Google Scholar
• Cuervo AM, Bergamini E, Brunk UT, Droge W, Ffrench M, Terman A . Autophagy and aging: the importance of maintaining ‘clean’ cells. Autophagy 2005; 1: 131–140.
  Article Google Scholar
• Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003; 37: 343–350.
  Article CAS Google Scholar
• Harris H, Rubinsztein DC . Control of autophagy as a therapy for neurodegenerative disease. Nat Rev Neurol 2012; 8: 108–117.
  Article CAS Google Scholar
• Hidvegi T, Ewing M, Hale P, Dippold C, Beckett C, Kemp C et al. An autophagy-enhancing drug promotes degradation of mutant α1-antitrypsin Z and reduces hepatic fibrosis. Science 2010; 329: 229–232.
  Article CAS Google Scholar
• Metzger D, Li M, Chambon P . Targeted somatic mutagenesis in the mouse epidermis. Methods Mol Biol 2005; 289: 329–340.
  PubMed Google Scholar
• Wang Y, Schattenberg JM, Rigoli RM, Storz P, Czaja MJ . Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1. J Biol Chem 2004; 279: 31089–31097.
  Article CAS Google Scholar
• Xu Y, Jones BE, Neufeld DS, Czaja MJ . Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor toxicity. Gastroenterology 1998; 115: 1229–1237.
  Article CAS Google Scholar
• Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q et al. MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Mol Ther 2011; 19: 526–535.
  Article CAS Google Scholar