Dynamic Behavior and Function of Foxp3+ Regulatory T Cells in Tumor Bearing Host (original) (raw)

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• Published: 01 February 2009

Cellular & Molecular Immunology volume 6, pages 3–13 (2009)Cite this article

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Abstract

Regulatory T cells (Tregs) expressing forkhead/winged-helix transcription factor Foxp3 represent a distinct lineage of lymphocytes which play a central role in protecting the host from autoimmune diseases. However, Tregs also pose a major problem to anti-tumor immunity. Growing body of evidence from both laboratory and clinical investigations has demonstrated that expansion and accumulation of these immunosuppressive cells correlates with advanced tumor growth and predicts poor disease prognosis. How tumor development subverts normal self-tolerance function of Tregs thereby thwarts host anti-tumor immunity remains elusive. This review will discuss our current knowledge in understanding the dynamics and plasticity of Foxp3+ Treg activation and induction in tumor bearing hosts and their interaction with various antigen presenting cells (APCs) in tumor microenvironment leading to the establishment of active local and systemic immune suppression.

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Authors and Affiliations

1. Department of Immunology, The University of Texas, MD Anderson Cancer Center, Houston, 77030, TX, USA
   F Xiao-Feng Qin
2. The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, 77030, TX, USA
   F Xiao-Feng Qin

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Correspondence toF Xiao-Feng Qin.

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Qin, FF. Dynamic Behavior and Function of Foxp3+ Regulatory T Cells in Tumor Bearing Host.Cell Mol Immunol 6, 3–13 (2009). https://doi.org/10.1038/cmi.2009.2

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• Received: 01 February 2009
• Accepted: 01 February 2009
• Issue date: 01 February 2009
• DOI: https://doi.org/10.1038/cmi.2009.2

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