Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics (original) (raw)
Hanahan D, Weinberg RA . Hallmarks of cancer: the next generation. Cell 2011; 144:646–674. ArticleCAS Google Scholar
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G . Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 2010; 11:700–714. ArticleCAS Google Scholar
Vanlangenakker N, Vanden Berghe T, Vandenabeele P . Many stimuli pull the necrotic trigger, an overview. Cell Death Differ 2012; 19:75–86. ArticleCAS Google Scholar
Morgan M, Liu Z . Programmed cell death with a necrotic-like phenotype. BioMol Concepts 2013; 4:259–275. ArticleCAS Google Scholar
Kaiser WJ, Upton JW, Long AB, et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011; 471:368–372. ArticleCAS Google Scholar
Oberst A, Dillon CP, Weinlich R, et al. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011; 471:363–367. ArticleCAS Google Scholar
Zhang H, Zhou X, McQuade T, Li J, Chan FK, Zhang J . Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011; 471:373–376. ArticleCAS Google Scholar
Lu JV, Weist BM, van Raam BJ, et al. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci USA 2011; 108:15312–15317. ArticleCAS Google Scholar
Bonnet MC, Preukschat D, Welz PS, et al. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 2011; 35:572–582. ArticleCAS Google Scholar
Gunther C, Martini E, Wittkopf N, et al. Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature 2011; 477:335–339. Article Google Scholar
Welz PS, Wullaert A, Vlantis K, et al. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 2011; 477:330–334. ArticleCAS Google Scholar
Moriwaki K, Chan FK . RIP3: a molecular switch for necrosis and inflammation. Genes Dev 2013; 27:1640–1649. ArticleCAS Google Scholar
Linkermann A, Brasen JH, Darding M, et al. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci USA 2013; 110:12024–12029. ArticleCAS Google Scholar
Kaiser WJ, Upton JW, Mocarski ES . Viral modulation of programmed necrosis. Curr Opin Virol 2013; 3:296–306. ArticleCAS Google Scholar
Zhang DW, Shao J, Lin J, et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009; 325:332–336. ArticleCAS Google Scholar
He S, Wang L, Miao L, et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009; 137:1100–1111. ArticleCAS Google Scholar
Cho YS, Challa S, Moquin D, et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009; 137:1112–1123. ArticleCAS Google Scholar
Zhao J, Jitkaew S, Cai Z, et al. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci USA 2012; 109:5322–5327. ArticleCAS Google Scholar
Sun L, Wang H, Wang Z, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012; 148:213–227. ArticleCAS Google Scholar
Wu J, Huang Z, Ren J, et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res 2013; 23:994–1006. ArticleCAS Google Scholar
Murphy JM, Czabotar PE, Hildebrand JM, et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 2013; 39:443–453. ArticleCAS Google Scholar
Cai Z, Jitkaew S, Zhao J, et al. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol 2014; 16:55–65. ArticleCAS Google Scholar
Chen X, Li W, Ren J, et al. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res 2014; 24:105–121. ArticleCAS Google Scholar
Wang H, Sun L, Su L, et al. Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell 2014; 54:133–146. ArticleCAS Google Scholar
Dondelinger Y, Declercq W, Montessuit S, et al. MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep 2014; 7:971–981. ArticleCAS Google Scholar
Tenev T, Bianchi K, Darding M, et al. The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 2011; 43:432–448. ArticleCAS Google Scholar
Dondelinger Y, Aguileta MA, Goossens V, et al. RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition. Cell Death Differ 2013; 20:1381–1392. ArticleCAS Google Scholar
Cook WD, Moujalled DM, Ralph TJ, et al. RIPK1- and RIPK3-induced cell death mode is determined by target availability. Cell Death Differ 2014; 21:1600–1612. ArticleCAS Google Scholar
Kim YS, Morgan MJ, Choksi S, Liu ZG . TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 2007; 26:675–687. ArticleCAS Google Scholar
Ventura JJ, Cogswell P, Flavell RA, Baldwin AS Jr, Davis RJ . JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 2004; 18:2905–2915. ArticleCAS Google Scholar
Degterev A, Hitomi J, Germscheid M, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008; 4:313–321. ArticleCAS Google Scholar
Li JX, Feng JM, Wang Y, et al. The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury. Cell Death Dis 2014; 5:e1278. ArticleCAS Google Scholar
Veeck J, Noetzel E, Bektas N, et al. Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer. Mol Cancer 2008; 7:83. Article Google Scholar
Irizarry RA, Ladd-Acosta C, Wen B, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 2009; 41:178–186. ArticleCAS Google Scholar
Ghoshal K, Datta J, Majumder S, et al. 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 2005; 25:4727–4741. ArticleCAS Google Scholar
Jezequel P, Campone M, Gouraud W, et al. bc-GenExMiner: an easy-to-use online platform for gene prognostic analyses in breast cancer. Breast Cancer Res Treat 2012; 131:765–775. Article Google Scholar
Biton S, Ashkenazi A . NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. Cell 2011; 145:92–103. ArticleCAS Google Scholar
Feoktistova M, Geserick P, Kellert B, et al. cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 2011; 43:449–463. ArticleCAS Google Scholar
Micheau O, Tschopp J . Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003; 114:181–190. ArticleCAS Google Scholar
Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB . Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 2004; 18:1272–1282. ArticleCAS Google Scholar
Sosna J, Voigt S, Mathieu S, et al. TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci 2014; 71:331–348. ArticleCAS Google Scholar
Kasof GM, Prosser JC, Liu DR, Lorenzi MV, Gomes BC . The RIP-like kinase, RIP3, induces apoptosis and NF-κB nuclear translocation and localizes to mitochondria. FEBS Lett 2000; 473:285–291. ArticleCAS Google Scholar
Newton K, Sun XQ, Dixit VM . Kinase RIP3 is dispensable for normal NF-κBs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and toll-like receptors 2 and 4. Mol Cell Biol 2004; 24:1464–1469. ArticleCAS Google Scholar
Sun XQ, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM . RIP3, a novel apoptosis-inducing kinase. J Biol Chem 1999; 274:16871–16875. ArticleCAS Google Scholar
Cowan LA, Talwar S, Yang AS . Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors. Epigenomics 2010; 2:71–86. ArticleCAS Google Scholar
Goldhirsch A, Wood WC, Coates AS, et al. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St Gallen International expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol 2011; 22:1736–1747. ArticleCAS Google Scholar
van de Vijver MJ, He YD, van't Veer LJ, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347:1999–2009. ArticleCAS Google Scholar
Pawitan Y, Bjohle J, Amler L, et al. Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res 2005; 7:R953–R964. ArticleCAS Google Scholar
Weigelt B, Hu Z, He X, et al. Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Cancer Res 2005; 65:9155–9158. ArticleCAS Google Scholar
Loi S, Haibe-Kains B, Desmedt C, et al. Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade. J Clin Oncol 2007; 25:1239–1246. ArticleCAS Google Scholar
Chanrion M, Negre V, Fontaine H, et al. A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer. Clin Cancer Res 2008; 14:1744–1752. ArticleCAS Google Scholar
Loi S, Haibe-Kains B, Desmedt C, et al. Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen. BMC Genomics 2008; 9:239. Article Google Scholar
Marcucci G, Yan P, Maharry K, et al. Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score. J Clin Oncol 2014; 32:548–556. Article Google Scholar